Abstract: A flanged joint system connects two pipes disposed along a common axis. A flange having a mating surface terminates each pipe. A gasket assembly comprising an outer annular, substantially rigid retaining ring and a peripheral alignment rim, an inner deformable annular sealing member is interposed between the mating surfaces of the flanges. The flanges and gasket assembly are aligned in mutually coaxial relationship by receipt of the flanges within the alignment rim. The flanges are clamped together with their mating surfaces in axially aligned, facing relationship. The retaining ring limits the impingement of the flanges and prevents overcompression of the deformable material. The joint is reliable and durable, and permits aseptic processing conditions to be maintained. Servicing and gasket replacement are readily accomplished.