Abstract: The invention relates to a process for obtaining agents having mitogenic and/or adjuvant properties, from Nocardia cells.According to this process Nocardia whole cells are subjected to a rupturing treatment of their walls within an aqueous medium, particularly distilled water. After the separation of the non-ruptured cells and of the wall fragments of the ruptured cells, mitogenic agents are extracted from the remaining aqueous phase. The fractions obtained are useful as laboratory reagents and for the production of medicamentous compositions in which they are associated with a pharmaceutical vehicle.

Abstract: Water soluble agents effective as immunological adjuvants for stimulating in the host the immune response to various antigens, comprising an acyl-muramic acid group, wherein acyl means acetyl or glycolyl, and a short peptide chain linked to said acyl-muramic acid group, the first and second amino acids of said peptide chain being preferentially alanine and glutamic acid respectively.

Abstract: The adjuvant is 2-(p-amino-phenyl-2-acetamido-2-deoxy-3-O-D-glucopyranosyl)-D-propionyl-L- alanyl-D-isoglutamine, which compound in its .beta. glucoside form, corresponds with the formula ##STR1## It is notably useful for favoring immunitory responses relative to antigens of low immunogenicity.

Abstract: The invention pertains to drug oil-free compositions, notably aqueous injectable compositions acting as non-specific adjuvants to stimulate in a host the immune responses to different antigens. The active principle of these oil-free compositions is N-acetyl-muramyl-L-alanyl-D-glutamic acid.

Abstract: The invention pertains to drug oil-free compositions, notably aqueous injectable compositions acting as non-specific adjuvants to stimulate in a host the immunitary responses to different antigens. The active principle of these oil-free compositions is N-acetyl-muramyl-L-alanyl-D-isoglutamine.

Abstract: The invention relates to new water-soluble agents which are effective as immunizing adjuvants. These adjuvant agents are the methyl, ethyl or propyl esters of 2-(2-acetamido-2-deoxy-3-O-D-glucopyranosyl)-D-propionyl-L-alanyl-D-isoglu tamine and of 2-(2-acetamido-2-deoxy-3-O-D-glucopyranosyl)-D-propionyl-L-alanyl-D-glutam ic acid, the 2-(2-acetamido-2-deoxy-3-O-D-glucopyranosyl)-D-propionyl-L-alanyl-D-(.alph a.-methylamide)-glutamic and 2-(2-acetamido-2-deoxy-3-O-D-glucopyranosyl)-D-propionyl-L-seryl-D-isoglut amine, the 2-(2-acetamido-2-deoxy-3-O-D-glucopyranosyl)-D-propionyl-L-seryl-D-glutami c acid and their derivatives. They are particularly useful to prepare adjuvant medicinal compositions, used for increasing the efficiency of vaccines.

Abstract: The present invention relates to novel immunological agents effective as adjuvants for stimulating an immune response to various types of antigens. The adjuvants do not cause objectionable reactions and they are easily purified. The invention additionally relates to a process for producing the novel adjuvants.

Abstract: Stabilized water-in-oil emulsions containing metabolizable vegetable oil, water in a quantity less than the oil and a non-immunogenic stabilizing protein in a quantity suitable to ensure the stability of the emulsion. Compositions which contain such an emulsion and a water soluble adjuvant and/or a vaccinating antigen in solution or suspension in the emulsion. A kit containing the above.

Abstract: Immunological adjuvants obtainable from already-known water-soluble adjuvants containing peptidoglycane fragments, which include saccharide units formed from N-acetylglucosamine and from an N-acyl-muramic acid wherein the acyl group is a glycolyl or acetyl group and to the muramyl group there are attached peptide chains, by modification of said already-known water-soluble adjuvants so that they bear acylating groups derived from physiologically-acceptable carboxylic polyacids, especially carboxylic diacids, and wherein preferably the acylating groups themselves include free carboxylic acid groups, for instance being derived from phthalic acid or succinic acid.

Abstract: The invention pertains to a mitrogenic agent and to a process for obtaining same.It comprises the steps of cultivating Nocardiae cells, collecting them, subjecting them to a treatment for rupturing the integrity of their walls, such as by lysis, discarding the solid residue and collecting the aqueous fraction, causing the peptidoglycane fragments contained in this aqueous fraction to be separated therefrom and recovering the remaining fraction containing the mitogenic agent.

Abstract: Water-soluble immunological adjuvants, extracted from mycobacteria and nocardia cells, useful for stimulating, in a host, the immune response to various kinds of antigens.

Abstract: The invention pertains to a water-soluble immunological adjuvant, especially for vaccines. It is obtained by enzymatic treatment of mycobacteria or Nocardia whole cells in aqueous medium and by a recovery from said aqueous medium.