Patents by Inventor Louis D. Falo, Jr.

Louis D. Falo, Jr. has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Publication number: 20220241570
    Abstract: The disclosed methods relate to forming microneedle arrays from a production mold that comprises a flexible mold material. The disclosed methods can be used to reproducibly manufacture undercut dissolvable and coated microneedle arrays with various shapes and structures.
    Type: Application
    Filed: May 15, 2020
    Publication date: August 4, 2022
    Applicant: University of Pittsburgh - Of the Commonwealth System of Higher Education
    Inventors: Louis D. Falo, JR., Emrullah Korkmaz
  • Publication number: 20220218821
    Abstract: Provided herein are compositions and methods for increasing an immune response in a subject, immunizing a subject and/or treating a disease in a subject that relate to keratinocytes. It is a surprising finding of the present invention that modulation of an XBP1 pathway creates a keratinocyte that is itself an immune modulator, or adjuvant. In some embodiments, the concentration of antigen is increased in the vicinity of the keratinocyte, further increasing the immune response by effector cells within that vicinity.
    Type: Application
    Filed: December 22, 2021
    Publication date: July 14, 2022
    Inventors: Louis D. FALO, JR., Zhaoyang YOU
  • Publication number: 20220193386
    Abstract: A method of forming a microneedle array can include forming a microneedle array having one or more chemotherapeutic agents. The microneedle array can include a base portion and plurality of microneedles extending from the base portion, and the one or more chemotherapeutic agents can be present in a higher concentration in the plurality of microneedles than in the base portion.
    Type: Application
    Filed: January 14, 2022
    Publication date: June 23, 2022
    Applicants: University of Pittsburgh - Of the Commonwealth System of Higher Education, Carnegie Mellon University
    Inventors: Louis D. Falo, JR., Geza Erdos, O. Burak Ozdoganlar
  • Publication number: 20210311062
    Abstract: The present invention relates to biomarkers associated with CTCL, including TOX, PLS3, KIR3DL2, GATA3 and RUNX3, where increased expression, relative to normal control, of one or more of TOX, PLS3, KIR3DL2, and/or GATA3 is associated with CTCL and decreased expression of RUNX3, relative to normal control, is associated with CTCL. One or more of these biomarkers may be used to diagnose CTCL and/or design and monitor treatment.
    Type: Application
    Filed: June 18, 2021
    Publication date: October 7, 2021
    Applicant: UNIVERSITY OF PITTSBURGH - OF THE COMMONWEALTH SYSTEM OF HIGHER EDUCATION
    Inventors: Larisa J. Geskin, Brittany Lynn O'Neill Dulmage, Louis D. Falo, JR.
  • Patent number: 11067577
    Abstract: The present invention relates to biomarkers associated with CTCL, including TOX, PLS3, KIR3DL2, GATA3 and RUNX3, where increased expression, relative to normal control, of one or more of TOX, PLS3, KIR3DL2, and/or GATA3 is associated with CTCL and decreased expression of RUNX3, relative to normal control, is associated with CTCL. One or more of these biomarkers may be used to diagnose CTCL and/or design and monitor treatment.
    Type: Grant
    Filed: September 25, 2019
    Date of Patent: July 20, 2021
    Assignee: UNIVERSITY OF PITTSBURGH—OF THE COMMONWEALTH SYSTEM OF HIGHER EDUCATION
    Inventors: Larisa J. Geskin, Brittany Lynn O'Neill Dulmage, Louis D. Falo, Jr.
  • Patent number: 10913776
    Abstract: Disclosed is an immunogen comprising a fusion protein, wherein the fusion protein comprises a Zika virus (ZIKV) envelope protein, optionally a signal peptide, and a multimerization domain. The signal peptide is a premembrane (prM) signal peptide, an IgG signal peptide, or a human secretory signal peptide hidden Markov model, and the multimerization domain is an immunoglobulin Fc domain, a T4 fibritin foldon trimerization domain, or a human collagen XV trimerization domain. Nucleic acids, vectors, and microneedle arrays including these compositions are disclosed. Methods of producing an immune response to ZIKV are also disclosed.
    Type: Grant
    Filed: September 29, 2017
    Date of Patent: February 9, 2021
    Assignee: University of Pittsburgh—Of the Commonwealth System of Higher Education
    Inventors: Andrea A. Gambotto, Eun Kim, Geza Erdos, Louis D. Falo, Jr.
  • Publication number: 20200397955
    Abstract: A method of forming a microneedle array can include forming a sheet of material having a plurality of layers and micromilling the sheet of material to form a microneedle array. At least one of the plurality of layers can include a bioactive component, and the microneedle array can include a base portion and plurality of microneedles extending from the base portion.
    Type: Application
    Filed: April 28, 2020
    Publication date: December 24, 2020
    Applicants: University of Pittsburgh - Of the Commonwealth System of Higher Education, Carnegie Mellon University
    Inventors: Louis D. Falo, JR., Geza Erdos, O. Burak Ozdoganlar
  • Publication number: 20200353235
    Abstract: Microneedle arrays and methods of forming the same can include one or more bioactive components bonded to a biocompatible material such that the one or more bioactive components are cleavable in vivo to release the bioactive component from the biocompatible material.
    Type: Application
    Filed: July 29, 2020
    Publication date: November 12, 2020
    Applicant: University of Pittsburgh - Of the Commonwealth System of Higher Education
    Inventors: Louis D. Falo, JR., Geza Erdos
  • Patent number: 10737083
    Abstract: Microneedle arrays and methods of forming the same can include one or more bioactive components bonded to a biocompatible material such that the one or more bioactive components are cleavable in vivo to release the bioactive component from the biocompatible material.
    Type: Grant
    Filed: February 22, 2019
    Date of Patent: August 11, 2020
    Assignee: University of Pittsburgh—Of the Commonwealth System of Higher Education
    Inventors: Louis D. Falo, Jr., Geza Erdos
  • Publication number: 20200033348
    Abstract: The present invention relates to biomarkers associated with CTCL, including TOX, PLS3, KIR3DL2, GATA3 and RUNX3, where increased expression, relative to normal control, of one or more of TOX, PLS3, KIR3DL2, and/or GATA3 is associated with CTCL and decreased expression of RUNX3, relative to normal control, is associated with CTCL. One or more of these biomarkers may be used to diagnose CTCL and/or design and monitor treatment.
    Type: Application
    Filed: September 25, 2019
    Publication date: January 30, 2020
    Applicant: UNIVERSITY OF PITTSBURGH - OF THE COMMONWEALTH SYSTEM OF HIGHER EDUCATION
    Inventors: Larisa J. Geskin, Brittany Lynn O'Neill Dulmage, Louis D. Falo, JR.
  • Publication number: 20200031874
    Abstract: Disclosed is an immunogen comprising a fusion protein, wherein the fusion protein comprises a Zika virus (ZIKV) envelope protein, optionally a signal peptide, and a multimerization domain. The signal peptide is a premembrane (prM) signal peptide, an IgG signal peptide, or a human secretory signal peptide hidden Markov model, and the multimerization domain is an immunoglobulin Fc domain, a T4 fibritin foldon trimerization domain, or a human collagen XV trimerization domain. Nucleic acids, vectors, and microneedle arrays including these compositions are disclosed. Methods of producing an immune response to ZIKV are also disclosed.
    Type: Application
    Filed: September 29, 2017
    Publication date: January 30, 2020
    Applicant: University of Pittsburgh - Of the Commonwealth System of Higher Education
    Inventors: Andrea A. Gambotto, Eun Kim, Geza Erdos, Louis D. Falo, JR.
  • Publication number: 20200000793
    Abstract: A method for preventing or treating skin damage in a radiotherapy subject, comprising topically administering to the subject a composition that includes a therapeutically effective amount at least one targeted nitroxide agent and at least one additional ingredient.
    Type: Application
    Filed: June 20, 2019
    Publication date: January 2, 2020
    Applicant: University of Pittsburgh - Of the Commonwealth System of Higher Education
    Inventors: Louis D. Falo, Jr., Joel S. Greenberger, Peter Wipf
  • Patent number: 10473661
    Abstract: The present invention relates to biomarkers associated with CTCL, including TOX, PLS3, KIR3DL2, GATA3 and RUNX3, where increased expression, relative to normal control, of one or more of TOX, PLS3, KIR3DL2, and/or GATA3 is associated with CTCL and decreased expression of RUNX3, relative to normal control, is associated with CTCL. One or more of these biomarkers may be used to diagnose CTCL and/or design and monitor treatment.
    Type: Grant
    Filed: August 6, 2015
    Date of Patent: November 12, 2019
    Assignee: UNIVERSITY OF PITTSBURGH—OF THE COMMONWEALTH SYSTEM OF HIGHER EDUCATION
    Inventors: Larisa J. Geskin, Brittany Lynn O'Neil Dulmage, Louis D. Falo, Jr.
  • Patent number: 10441768
    Abstract: Microneedle arrays and methods of forming the same can include one or more bioactive components bonded to a biocompatible material such that the one or more bioactive components are cleavable in vivo to release the bioactive component from the biocompatible material.
    Type: Grant
    Filed: March 18, 2016
    Date of Patent: October 15, 2019
    Assignee: University of Pittsburgh—Of the Commonwealth System of Higher Education
    Inventors: Louis D. Falo, Jr., Geza Erdos
  • Publication number: 20190255307
    Abstract: Microneedle arrays and methods of forming the same can include one or more bioactive components bonded to a biocompatible material such that the one or more bioactive components are cleavable in vivo to release the bioactive component from the biocompatible material.
    Type: Application
    Filed: February 22, 2019
    Publication date: August 22, 2019
    Applicant: University of Pittsburgh - Of the Commonwealth System of Higher Education
    Inventors: Louis D. Falo, JR., Geza Erdos
  • Publication number: 20190000966
    Abstract: Methods are provided for promoting, reducing, or desensitizing various immune responses by delivery of sub-immunogenic doses of an allergen, alone or with other agents, or by delivery of antigens and adjuvants to a cutaneous microenvironment of a subject. Microneedle arrays can be used in connection with this delivery.
    Type: Application
    Filed: January 5, 2017
    Publication date: January 3, 2019
    Applicant: University of Pittsburgh - Of the Commonwealth System of Higher Education
    Inventors: Louis D. Falo, JR., Adriana Teresita Larregina De Morelli
  • Publication number: 20180304062
    Abstract: A method of forming a microneedle array can include forming a microneedle array that has one or more bioactive component. The microneedle array can include a base portion and plurality of microneedles extending from the base portion, and the one or more bioactive components can be combined with other components to exhibit specific release kinetics when the microneedle array is inserted into the skin of a patient.
    Type: Application
    Filed: October 17, 2016
    Publication date: October 25, 2018
    Applicant: University of Pittsburgh - Of the Commonwealth System of Higher Education
    Inventors: Louis D. FALO, JR., Geza ERDOS
  • Publication number: 20180272621
    Abstract: A method of forming a microneedle array can include forming a microneedle array that has one or more bioactive component. The microneedle array can include a base portion and plurality of microneedles extending from the base portion, and the one or more bioactive components are present in a higher concentration in the plurality of microneedles than in the base portion.
    Type: Application
    Filed: March 26, 2018
    Publication date: September 27, 2018
    Applicants: University of Pittsburgh - Of the Commonwealth System of Higher Education, Carnegie Mellon University
    Inventors: Louis D. Falo, Jr., Geza Erdos, O. Burak Ozdoganlar
  • Publication number: 20180177868
    Abstract: Provided herein are compositions and methods for increasing an immune response in a subject, immunizing a subject and/or treating a disease in a subject that relate to keratinocytes. It is a surprising finding of the present invention that modulation of an XBP1 pathway creates a keratinocyte that is itself an immune modulator, or adjuvant. In some embodiments, the concentration of antigen is increased in the vicinity of the keratinocyte, further increasing the immune response by effector cells within that vicinity.
    Type: Application
    Filed: June 24, 2016
    Publication date: June 28, 2018
    Inventors: Louis D. FALO, Jr., Zhaoyang YOU
  • Patent number: 9944019
    Abstract: A method of forming a microneedle array can include forming a microneedle array that has one or more bioactive component. The microneedle array can include a base portion and plurality of microneedles extending from the base portion, and the one or more bioactive components are present in a higher concentration in the plurality of microneedles than in the base portion.
    Type: Grant
    Filed: May 1, 2013
    Date of Patent: April 17, 2018
    Assignees: University of Pittsburgh—Of the Commonwealth System of Higher Education, Carnegie Mellon University
    Inventors: Louis D. Falo, Jr., Geza Erdos, O. Burak Ozdoganlar