Patents by Inventor Louis F. Cannizzo
Louis F. Cannizzo has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 9133150Abstract: The present invention provides O-nitro compounds, pharmaceutical compositions of O-nitro compounds and methods of using O-nitro compounds and/or pharmaceutical compositions thereof to treat or prevent diseases or disorders characterized by abnormal cell proliferation, such as cancer, inflammation, cardiovascular disease and autoimmune disease.Type: GrantFiled: July 26, 2013Date of Patent: September 15, 2015Assignee: ORBITAL ATK, INC.Inventors: Mark D. Bednarski, Susan Knox, Louis F. Cannizzo, Kirstin F. Warner, Robert B. Wardle, Stephen P. Velarde, Shoucheng Ning
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Publication number: 20130309324Abstract: The present invention provides O-nitro compounds, pharmaceutical compositions of O-nitro compounds and methods of using O-nitro compounds and/or pharmaceutical compositions thereof to treat or prevent diseases or disorders characterized by abnormal cell proliferation, such as cancer, inflammation, cardiovascular disease and autoimmune disease.Type: ApplicationFiled: July 26, 2013Publication date: November 21, 2013Applicants: RadioRx, Inc., c/o Interwest Venture Partners, Alliant Techsystems Inc.Inventors: Mark D. Bednarski, Susan Knox, Louis F. Cannizzo, Kristin F. Warner, Robert B. Wardle, Stephen P. Velarde, Shoucheng Ning
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Patent number: 8530681Abstract: The present invention provides O-nitro compounds, pharmaceutical compositions of O-nitro compounds and methods of using O-nitro compounds and/or pharmaceutical compositions thereof to treat or prevent diseases or disorders characterized by abnormal cell proliferation, such as cancer, inflammation, cardiovascular disease and autoimmune disease.Type: GrantFiled: May 30, 2012Date of Patent: September 10, 2013Assignee: Alliant Techsystems Inc.Inventors: Susan Knox, Louis F. Cannizzo, Kirstin F. Warner, Robert B. Wardle, Stephen P. Velarde, Shoucheng Ning, Lynn M. Oehler
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Patent number: 8471041Abstract: A method of synthesizing and isolating N-(bromoacetyl)-3,3-dinitroazetidine (ABDNAZ) by reacting DNAZ with bromoacetyl bromide and boron trifluoride etherate to produce a mixture comprising ABDNAZ and a salt of DNAZ. Water and a solvent are added to the mixture to form an organic phase comprising the ABDNAZ and an aqueous phase comprising the salt of DNAZ. The organic phase and the aqueous phase are separated to produce an ABDNAZ/solvent solution comprising the ABDNAZ and the aqueous phase comprising the salt of DNAZ. A nonsolvent is added to the ABDNAZ/solvent solution to produce an ABDNAZ/solvent/nonsolvent mixture. The ABDNAZ is subsequently recovered. A composition comprising ABDNAZ is also disclosed.Type: GrantFiled: February 9, 2010Date of Patent: June 25, 2013Assignee: Alliant Techsystems Inc.Inventors: Nicholas A. Straessler, Louis F. Cannizzo, Ping Li, Michael P. Kramer, David M. Rosenberg
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Patent number: 8178698Abstract: The present invention provides cyclic nitro compounds, pharmaceutical compositions of cyclic nitro compounds and methods of using cyclic nitro compounds and/or pharmaceutical compositions thereof to treat or prevent diseases or disorders characterized by abnormal cell proliferation, such as cancer, inflammation, cardiovascular disease and autoimmune disease.Type: GrantFiled: May 26, 2010Date of Patent: May 15, 2012Assignee: Alliant Techsystems Inc.Inventors: Louis F. Cannizzo, Kirstin F. Warner, Robert B. Wardle, Stephen P. Velarde
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Publication number: 20110195947Abstract: A method of synthesizing and isolating N-(bromoacetyl)-3,3-dinitroazetidine (ABDNAZ) by reacting DNAZ with bromoacetyl bromide and boron trifluoride etherate to produce a mixture comprising ABDNAZ and a salt of DNAZ. Water and a solvent are added to the mixture to form an organic phase comprising the ABDNAZ and an aqueous phase comprising the salt of DNAZ. The organic phase and the aqueous phase are separated to produce an ABDNAZ/solvent solution comprising the ABDNAZ and the aqueous phase comprising the salt of DNAZ. A nonsolvent is added to the ABDNAZ/solvent solution to produce an ABDNAZ/solvent/nonsolvent mixture. The ABDNAZ is subsequently recovered. A composition comprising ABDNAZ is also disclosed.Type: ApplicationFiled: February 9, 2010Publication date: August 11, 2011Applicant: ALLIANT TECHSYSTEMS INC.Inventors: Nicholas A. Straessler, Louis F. Cannizzo, Ping Li, Michael P. Kramer, David M. Rosenberg
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Publication number: 20110130572Abstract: The present invention provides cyclic nitro compounds, pharmaceutical compositions of cyclic nitro compounds and methods of using cyclic nitro compounds and/or pharmaceutical compositions thereof to treat or prevent diseases or disorders characterized by abnormal cell proliferation, such as cancer, inflammation, cardiovascular disease and autoimmune disease.Type: ApplicationFiled: May 26, 2010Publication date: June 2, 2011Applicant: ALLIANT TECHSYSTEMS INC.Inventors: Louis F. Cannizzo, Kirstin F. Warner, Robert B. Wardle, Stephen P. Velarde
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Patent number: 7745643Abstract: The present invention provides cyclic nitro compounds, pharmaceutical compositions of cyclic nitro compounds and methods of using cyclic nitro compounds and/or pharmaceutical compositions thereof to treat or prevent diseases or disorders characterized by abnormal cell proliferation, such as cancer, inflammation, cardiovascular disease and autoimmune disease.Type: GrantFiled: October 15, 2008Date of Patent: June 29, 2010Assignee: Alliant Techsystems Inc.Inventors: Louis F. Cannizzo, Kirstin F. Warner, Robert B. Wardle, Stephen P. Velarde
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Publication number: 20090093644Abstract: The present invention provides cyclic nitro compounds, pharmaceutical compositions of cyclic nitro compounds and methods of using cyclic nitro compounds and/or pharmaceutical compositions thereof to treat or prevent diseases or disorders characterized by abnormal cell proliferation, such as cancer, inflammation, cardiovascular disease and autoimmune disease.Type: ApplicationFiled: October 15, 2008Publication date: April 9, 2009Applicant: ALLIANT TECHSYSTEMS INC.Inventors: Louis F. Cannizzo, Kirstin F. Warner, Robert B. Wardle, Stephen P. Velarde
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Publication number: 20090088506Abstract: This thermoplastic elastomer is present in a substantially solid state suitable for use as a binder for a propellant, explosive, and/or gas generant of a supplemental restraint system. The thermoplastic elastomer is formed from a composition including A blocks which are crystalline at temperatures below about 75° C. and B blocks which are amorphous at temperatures above about ?20° C. The A blocks are derived from oxetane derivatives and the B blocks are derived from oxiranes and derivatives thereof. The A blocks and B blocks are end-capped with a diisocyanate having a first isocyanate moiety that is substantially more reactive with the terminal groups of the blocks than the second isocyanate moiety, whereby the more reactive first isocyanate moiety is capable of reacting with the terminal groups of the blocks, leaving the less reactive second isocyanate moiety free and unreacted.Type: ApplicationFiled: June 12, 2008Publication date: April 2, 2009Applicant: ALLIANT TECHSYSTEMS INC.Inventors: Andrew J. Sanderson, Wayne Edwards, Louis F. Cannizzo, Robert B. Wardle
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Patent number: 7101955Abstract: This thermoplastic elastomer is present in a substantially solid state suitable for use as a binder for a propellant, explosive, and/or gas generant of a supplemental restraint system. The thermoplastic elastomer is formed from a composition including A blocks which are crystalline at temperatures below about 75° C. and B blocks which are amorphous at temperatures above about ?20° C. The A blocks are derived from oxetane derivatives and the B blocks are derived from oxiranes and derivatives thereof. The A blocks and B-blocks are end-capped with a diisocyanate having a first isocyanate moiety that is substantially more reactive with the terminal groups of the blocks than the second isocyanate moiety, whereby the more reactive first isocyanate moiety is capable of reacting with the terminal groups of the blocks, leaving the less reactive second isocyanate moiety free and unreacted.Type: GrantFiled: November 9, 1999Date of Patent: September 5, 2006Assignee: Alliant Techsystems Inc.Inventors: Andrew J. Sanderson, Wayne Edwards, Louis F. Cannizzo, Robert B. Wardle
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Patent number: 7101449Abstract: Nitramines are one of the more expensive and often the more plentiful ingredients found in energetic materials, such as solid rocket motor propellants, explosives, and pyrotechnics. By treating aluminized energetic material with an aqueous nitric acid solution containing not more than 55% by weight aqueous nitric acid at a weight ratio of aqueous nitric acid to energetic material of about 4:1 to about 6:1, most constituents of conventional aluminized energetic materials are digested into solution, with the exception of nitramines, which remain substantially insoluble in the aqueous nitric acid and can be recovered without requiring recrystallization of the nitramines. A mineral acid other than nitric acid, preferably hydrochloric acid, may be added to increase the rate of aluminum digestion. Treatment of the energetic material can be performed without volatile organic solvents, thus obviating ecological, cost, and safety concerns raised by the use of volatile organic solvents.Type: GrantFiled: August 22, 2003Date of Patent: September 5, 2006Assignee: Alliant Techsystems Inc.Inventors: Kirstin F. Warner, Louis F. Cannizzo, Robert M. Hajik
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Publication number: 20040039229Abstract: Nitramines are one of the more expensive and often the more plentiful ingredients found in energetic materials, such as solid rocket motor propellants, explosives, and pyrotechnics. By treating aluminized energetic material with an aqueous nitric acid solution containing not more than 55% by weight aqueous nitric acid at a weight ratio of aqueous nitric acid to energetic material of about 4:1 to about 6:1, most constituents of conventional aluminized energetic materials are digested into solution, with the exception of nitramines, which remain substantially insoluble in the aqueous nitric acid and can be recovered without requiring recrystallization of the nitramines. A mineral acid other than nitric acid, preferably hydrochloric acid, may be added to increase the rate of aluminum digestion. Treatment of the energetic material can be performed without volatile organic solvents, thus obviating ecological, cost, and safety concerns raised by the use of volatile organic solvents.Type: ApplicationFiled: August 22, 2003Publication date: February 26, 2004Inventors: Kirstin F. Warner, Louis F. Cannizzo, Robert M. Hajik
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Patent number: 6610156Abstract: Nitramines are one of the more expensive and often the more plentiful ingredients found in energetic materials, such as solid rocket motor propellants, explosives, and pyrotechnics. By treating aluminized energetic material with an aqueous nitric acid solution containing not more than 55% by weight aqueous nitric acid at a weight ratio of aqueous nitric acid to energetic material of about 4:1 to about 6:1, most constituents of conventional aluminized energetic materials are digested into solution, with the exception of nitramines, which remain substantially insoluble in the aqueous nitric acid and can be recovered without requiring recrystallization of the nitramines. A mineral acid other than nitric acid, preferably hydrochloric acid, may be added to increase the rate of aluminum digestion. Treatment of the energetic material can be performed without volatile organic solvents, thus obviating ecological, cost, and safety concerns raised by the use of volatile organic solvents.Type: GrantFiled: February 15, 2001Date of Patent: August 26, 2003Assignee: Alliant Techsystems Inc.Inventors: Kirstin F. Warner, Louis F. Cannizzo, Robert M. Hajik
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Publication number: 20030111148Abstract: Nitramines are one of the more expensive and often the more plentiful ingredients found in energetic materials, such as solid rocket motor propellants, explosives, and pyrotechnics. By treating aluminized energetic material with an aqueous nitric acid solution containing not more than 55% by weight aqueous nitric acid at a weight ratio of aqueous nitric acid to energetic material of about 4:1 to about 6:1, most constituents of conventional aluminized energetic materials are digested into solution, with the exception of nitramines, which remain substantially insoluble in the aqueous nitric acid and can be recovered without requiring recrystallization of the nitramines. A mineral acid other than nitric acid, preferably hydrchloric acid, may be added to increase the rate of aluminum digestion. Treatment of the energetic material can be performed without volatile organic solvents, thus obviating ecological, cost, and safety concerns raised by the use of volatile organic solvents.Type: ApplicationFiled: February 15, 2001Publication date: June 19, 2003Applicant: Cordant Technologies Inc.Inventors: Kirstin F. Warner, Louis F. Cannizzo, Robert M. Hajik
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Patent number: 6425966Abstract: 2,2-dinitro-1,3-propanediol-diformate is a novel low sensitivity, energetic plasticizer that is useful in explosive and propellant compositions. 2,2-dinitro-1,3-propanediol-diformate can be made by reacting 2,2-dinitro-1,3-propane diol with acetic formic anhydride in the presence of pyridine and at least one solvent.Type: GrantFiled: September 14, 2000Date of Patent: July 30, 2002Assignee: Alliant Techsystems Inc.Inventors: Thomas K. Highsmith, Daniel W. Doll, Louis F. Cannizzo
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Patent number: 6416601Abstract: Nitramines are one of the more expensive and often the more plentiful ingredients found in energetic materials, such as solid rocket motor propellants, explosives, and pyrotechnics. By treating aluminized energetic material with an aqueous nitric acid solution containing not more than 55% by weight aqueous nitric acid at a weight ratio of aqueous nitric acid to energetic material of about 4:1 to about 6:1, most constituents of conventional aluminized energetic materials are digested into solution, with the exception of nitramines, which remain substantially insoluble in the aqueous nitric acid and can be recovered without requiring recrystallization of the nitramines. A mineral acid other than nitric acid, preferably hydrochloric acid, is added to increase the rate of aluminum digestion. Treatment of the energetic material can be performed without volatile organic solvents, thus obviating ecological, cost, and safety concerns raised by the use of volatile organic solvents.Type: GrantFiled: February 15, 2001Date of Patent: July 9, 2002Assignee: Alliant Techsystems Inc.Inventors: Kirstin F. Warner, Louis F. Cannizzo, Robert M. Hajik, Harold E. Johnston
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Polymerization of poly(glycidyl nitrate) from high purity glycidyl nitrate synthesized from glycerol
Patent number: 6362311Abstract: Glycerol is nitrated with at least one nitrating source in a solvent to form a nitrated glycerol solution containing dinitroglycerin. The nitrated glycerol solution is treated with at least one cyclizing agent to convert the dinitroglycerin into glycidyl nitrate, which is polymerized into poly(glycidyl nitrate) (PGN). Distillation or other vaporization techniques are not required to remove nitroglycerin from the glycidyl nitrate prior to polymerization of the glycidyl nitrate. Rather, the nitroglycerin can be carried along with the dinitroglycerin during polymerization. As a consequence, the glycidyl nitrate is not exposed to elevated temperatures sufficient to cause accidental explosion or deflagration of the nitrate ester. Still more preferably, the glycidyl nitrate is not heated above room temperature at any time prior to polymerization. Moreover, given the high energy performance of nitroglycerin, the nitroglycerin can optionally be retained with the PGN, i.e.Type: GrantFiled: October 17, 2000Date of Patent: March 26, 2002Assignee: Alliant Techsystems Inc.Inventors: Thomas K. Highsmith, Andrew J. Sanderson, Louis F. Cannizzo, Robert M. Hajik -
Publication number: 20020028971Abstract: Nitramines are one of the more expensive and often the more plentiful ingredients found in energetic materials, such as solid rocket motor propellants, explosives, and pyrotechnics. By treating aluminized energetic material with an aqueous nitric acid solution containing not more than 55% by weight aqueous nitric acid at a weight ratio of aqueous nitric acid to energetic material of about 4:1 to about 6:1, most constituents of conventional aluminized energetic materials are digested into solution, with the exception of nitramines, which remain substantially insoluble in the aqueous nitric acid and can be recovered without requiring recrystallization of the nitramines. A mineral acid other than nitric acid, preferably hydrchloric acid, is added to increase the rate of aluminum digestion. Treatment of the energetic material can be performed without volatile organic solvents, thus obviating ecological, cost, and safety concerns raised by the use of volatile organic solvents.Type: ApplicationFiled: February 15, 2001Publication date: March 7, 2002Applicant: Cordant Technologies Inc.Inventors: Kirstin F. Warner, Louis F. Cannizzo, Robert M. Hajik, Harold E. Johnston
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Patent number: 5723604Abstract: A process of synthesizing HBIW using a mineral acid, such as perchloric acid, as the acid catalyst is disclosed. According to the process, glyoxal, adjusted to a pH from 4 to 7, and benzylamine are reacted in the presence of the mineral acid for sufficient time to form HBIW. The resulting HBIW is then isolated according to conventional separation techniques.Type: GrantFiled: June 22, 1995Date of Patent: March 3, 1998Assignee: Thiokol CorporationInventors: Louis F. Cannizzo, William W. Edwards, Robert B. Wardle, Thomas K. Highsmith