Patents by Inventor Louis Flamondon

Louis Flamondon has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Synthesis of clasto-lactacystin ?-lactone and analogs thereof
    Patent number: 6849743
    Abstract: The present invention is directed to an improved synthesis of clasto-lactacystin-?-lactone, and analogs thereof, that proceeds in fewer steps and in much greater overall yield than syntheses described in the prior art. The synthetic pathway relies upon a novel stereospecific synthesis of an oxazoline intermediate and a unique stereoselective addition of a formyl amide to the oxazoline. Also described are novel clasto-lactacystin-?-lactones, and analogs thereof and their use as proteasome inhibitors.
    Type: Grant
    Filed: December 18, 2003
    Date of Patent: February 1, 2005
    Assignee: Millennium Pharmaceuticals, Inc.
    Inventors: François Soucy, Louis Flamondon, Mark Behnke, William Roush
  • Synthesis of clasto-lactacystin beta-lactone and analogs thereof
    Publication number: 20040171608
    Abstract: The present invention is directed to an improved synthesis of clasto-lactacystin-&bgr;-lactone, and analogs thereof, that proceeds in fewer steps and in much greater overall yield than syntheses described in the prior art. The synthetic pathway relies upon a novel stereospecific synthesis of an oxazoline intermediate and a unique stereoselective addition of a formyl amide to the oxazoline. Also described are novel clasto-lactacystin-&bgr;-lactones, and analogs thereof and their use as proteasome inhibitors.
    Type: Application
    Filed: December 18, 2003
    Publication date: September 2, 2004
    Applicant: Millennium Pharmaceuticals, Inc.
    Inventors: Francois Soucy, Louis Flamondon, Mark Behnke, William Roush