Abstract: Disclosed herein are techniques related to determination of adjustments to fluid delivery settings. In some embodiments, the techniques may involve accessing insulin delivery data for a user of an insulin delivery device. The insulin delivery data may be indicative of an amount of insulin delivered by the insulin delivery device to the user during a time period. The techniques may also involve analyzing the insulin delivery data to generate an updated insulin sensitivity factor (ISF) value. The techniques may further involve generating, based on the updated ISF value, a recommendation to adjust an ISF value of the insulin delivery device. Additionally, the techniques may involve causing adjustment of the ISF value to the updated ISF value in accordance with the recommendation.

Abstract: Methods and systems are provided for configuring therapy settings of a medical device for a specific patient. Patient data input via a non-medical device can be received. A value of a total daily dose of insulin for the specific patient can be obtained from the patient data. Based upon the value of the total daily dose, a set of therapy settings for the specific patient can be computed. The medical device can be automatically programmed with the set of therapy settings to complete set up of the medical device so that the medical device is configured for the specific patient.

Abstract: The present disclosure relates to default carbohydrate consumption counts based on characteristics of persons. Aspects of the present disclosure relate to accessing at least one characteristic of a person, obtaining a default carbohydrate consumption count for the person based on the at least one characteristic of the person, and causing delivery of insulin to the person based on the default carbohydrate consumption count.

Abstract: The present disclosure relates to default carbohydrate consumption counts based on population carbohydrate consumption models. Aspects of the present disclosure relate to receiving, from a device, at least one characteristic of a person; accessing a population carbohydrate consumption model which relates the at least one characteristic with carbohydrate intake for a population; determining, based on applying the population carbohydrate consumption model to the at least one characteristic, at least one of: a preliminary carbohydrate count for the person or a default carbohydrate consumption count for the person; and causing delivery of insulin to the person based on communicating, to the device, at least one of: the preliminary carbohydrate count for the person or the default carbohydrate consumption count for the person.

Abstract: Infusion systems, infusion devices, and related operating methods are provided. A method of operating an infusion device involves obtaining an input qualitative event attribute, such as a meal size, obtaining a quantitative event attribute associated with the qualitative event attribute that is representative of a subset of historical events for a patient associated with the qualitative event attribute, such as a representative carbohydrate amount for the qualitative meal size, and thereafter determine a dosage of fluid based at least in part on the quantitative event attribute and operate the infusion device to deliver the dosage of the fluid to the patient.

Abstract: A system includes one or more processors and one or more processor-readable storage media storing instructions which, when executed by the one or more processors, cause performance of obtaining a first target value for a glucose level of a patient, modifying a glucose setpoint from a second target value to the first target value, and regulating the glucose level of the patient to the modified glucose setpoint based on controlling insulin delivery by an insulin infusion device.

Abstract: A system includes one or more processors and one or more processor-readable storage media storing instructions which, when executed by the one or more processors, cause performance of receiving, via a user interface, confirmation input that indicates user acceptance of a blood glucose (BG) measurement generated by a BG meter device, in response to receiving the confirmation input, using the BG measurement for performing both glucose sensor calibration and bolus calculation, and causing delivery of a bolus based on outputting a delivery command in accordance with the bolus calculation.

Abstract: Disclosed is a method of controlling operation of a medical device that regulates delivery of a fluid medication to a user. The method obtains a current sensor-generated value that is indicative of a physiological characteristic of the user, and is produced in response to operation of a continuous analyte sensor device. The method continues by: calculating a sensor quality metric that indicates reliability and trustworthiness of the current sensor-generated value; adjusting, in response to the calculated sensor quality metric, therapy actions of the medical device to configure a quality-specific operating mode of the medical device; managing generation of user alerts at the medical device in response to the calculated sensor quality metric; and regulating delivery of the fluid medication from the medical device, in accordance with the current sensor-generated value and the quality-specific operating mode of the medical device.

Abstract: A medical device system and related method of automatically adjusting parameters of an insulin delivery controller of an insulin infusion device are disclosed. The methodology obtains therapy-related data associated with operation of the insulin infusion device for a number of days in the past, including sensor glucose data associated with glucose levels of the user, and meal data associated with identified meals. The obtained therapy-related data is processed to generate a suitable pharmacokinetic/pharmacodynamic (PK/PD) model of the user, wherein the PK/PD model fits at least some of the sensor glucose data obtained for the user. The PK/PD model can be used to calculate at least one adjusted parameter of the insulin delivery controller, based on additional therapy-related data associated with further operation of the insulin infusion device. The insulin delivery controller can be instructed or controlled to adjust its settings in accordance with the model-calculated parameters.

Abstract: Disclosed here is a computer-based device and related methodology that manages use of a dual-mode insulin infusion device. The infusion device operates in a manual insulin delivery mode or an automated closed-loop insulin delivery mode. The methodology receives closed-loop pump data for a user of the infusion device, the closed-loop pump data including data indicating basal insulin delivered by the infusion device during operation in the automated closed-loop insulin delivery mode for at least one defined period of time. The methodology analyzes the closed-loop pump data to generate updated basal rate data for the user, and generates, from the updated basal rate data, a recommendation to adjust a manual-mode basal rate setting of the infusion device. In certain scenarios, the infusion device is controlled such that the manual-mode basal rate setting is adjusted in accordance with the recommendation.

Abstract: Infusion systems, infusion devices, and related operating methods are provided. An exemplary method involves operating an infusion device to deliver fluid to a user in accordance with a first operating mode of a plurality of operating modes, obtaining operational information pertaining to the first operating mode, and obtaining clinical information pertaining to the user. A destination operating mode of the plurality of operating modes is determined based at least in part on the operational information and the clinical information, and the infusion device is operated to deliver the fluid in accordance with the destination operating mode in a manner that is influenced by at least a portion of the operational information pertaining to the first operating mode.

Abstract: An insulin infusion device and related operating methods are disclosed. An operating method maintains a configurable, patient-specific, target glucose setpoint for a user of the insulin infusion device, collects historical data associated with operation of the insulin infusion device, and calculates, from the historical data, a target glucose setpoint profile for the user of the insulin infusion device. A current target glucose setpoint value is automatically adjusted over time during a closed-loop operating mode of the insulin infusion device, in accordance with the calculated target glucose setpoint profile. In certain embodiments, the historical data is analyzed to determine a clinically preferred target glucose setpoint value for the user, which is stored for use during the closed-loop operating mode.

Abstract: Medical devices and related systems and operating methods are provided. A method of operating an infusion device capable of delivering fluid influencing a physiological condition to a patient involves obtaining an event indication, such as a meal indication, determining an initial bolus amount based on the event indication, and determining predicted values for the physiological condition of the patient during a time window into the future based at least in part on the initial bolus amount. When the predicted values violate a threshold during the time window, the control system identifies an adjusted bolus amount that results in the predicted values for the physiological condition satisfying the threshold during the time window from within a search space defined by the initial bolus amount and operates an actuation arrangement of the infusion device to deliver the adjusted bolus amount of the fluid to the patient.

Abstract: An insulin infusion device and a related operating method are disclosed. The method obtains a blood glucose (BG) measurement of a blood sample from a user, displays the BG measurement on a display element of the infusion device, and receives a confirmation input that indicates user acceptance of the displayed BG measurement. In response to the confirmation input, a glucose sensor calibration routine is automatically initiated, and an insulin bolus calculation is automatically initiated. The calibration routine and the bolus calculation use the confirmed BG measurement. The method continues by controlling delivery of insulin, in accordance with the calculated insulin bolus, from a fluid reservoir of the insulin infusion device. The sensor calibration routine and the insulin bolus calculation are both performed without any additional user involvement or interaction with the user interface other than the user acceptance of the displayed BG measurement.

Abstract: Infusion systems, infusion devices, and related operating methods are provided. An exemplary method of operating an infusion device capable of delivering fluid to a user involves determining a current value for a physiological condition of the user influenced by the fluid violates a first threshold value, determining a predicted value for the physiological condition of the user violates a second threshold value, and automatically altering operation of the infusion device to modify delivery of the fluid to the user after determining the predicted value violates the second threshold value when the current value violates the first threshold value.

Abstract: Gesture-informed patient management systems and related medical devices and operating methods are provided. A method of operating a medical device involves identifying a current operational context, predicting an occurrence of an event based at least in part on historical data associated with the patient and a correlation between the current operational context and the event, automatically configuring operation of the medical device to influence a physiological condition of the patient to account for the predicted occurrence of the event, and after configuring the operation of the medical device to account for the predicted occurrence of the event, automatically reconfiguring the operation of the medical device in response to detected gesture data influenced by an output of a sensing arrangement.

Abstract: Systems and related operating methodologies are disclosed. An exemplary operating method obtains sensor data that indicates a physiological characteristic of the user, the sensor data provided by an analyte sensor, and determines that a current level of the physiological characteristic differs from a user-specific target level by a quantifiable amount. The method continues by searching an activity correlation database to locate one or more physical activity events correlated with the quantifiable amount of the physiological characteristic. The activity correlation database is populated with event-correlated physiological responses that associate physical activity events with corresponding changes in the physiological characteristic. A recommendation is provided for the user. The recommendation specifies the one or more physical activity events.

Abstract: A method, system and non-transient computer-readable medium are provided for training a mathematical model of a user based on data received from a discrete insulin therapy system. Training data from a discrete insulin therapy system of a user is received that includes therapy-related data and settings (data that indicates: insulin delivery to the user during a period; carbohydrate intake by the user during the period; and blood glucose levels of the user during the period. A mathematical model that represents physiology of the user can be trained based on the training data to generate an adapted mathematical model of the user that simulates a physiological blood glucose response of the user.

Abstract: Infusion systems, infusion devices, and related operating methods are provided. An exemplary method involves operating an infusion device to deliver fluid to a user in accordance with a first operating mode of a plurality of operating modes, obtaining operational information pertaining to the first operating mode, and obtaining clinical information pertaining to the user. A destination operating mode of the plurality of operating modes is determined based at least in part on the operational information and the clinical information, and the infusion device is operated to deliver the fluid in accordance with the destination operating mode in a manner that is influenced by at least a portion of the operational information pertaining to the first operating mode.

Abstract: A pump for delivering a fluid includes a pump housing that defines at least one reservoir having a circumferentially open first end, a circumferentially closed second end and a chamber to receive the fluid. The pump includes a plunger assembly having at least one plunger arm and a cannula fluidly coupled to the plunger arm to dispense the fluid from the pump. The plunger arm is receivable within the first end of the reservoir, and the at least one plunger arm defining an internal conduit to receive the fluid from the at least one fluid reservoir. The internal conduit is fluidly coupled to the cannula. The plunger assembly is movable in a first direction relative to the pump housing to advance the plunger arm within the fluid reservoir to dispense the fluid from the fluid reservoir out of the pump via the cannula.