Abstract: A method and apparatus are provided for measuring the concentration of contaminants in an aqueous water system, wherein the contaminants are measured with the bioreactor containing a biofilm or microbial community which acts on the water to be analyzed to provide a measure of the amount of the dissolved organic carbon which is biodegradable. A bed for facilitating regulation of water flow through the bioreactor is provided, and an autosampling mechanism enables the measurement of total organic carbon, inorganic carbon and oxygen, between sample inflow and sample outflow at specified time intervals.

Abstract: A method and apparatus are provided for measuring the concentration of contaminants in an aqueous water system, wherein the contaminants are measured with the bioreactor containing a biofilm or microbial community which acts on the water to be analyzed to provide a measure of the amount of the dissolved organic carbon which is biodegradable. A bed for facilitating regulation of water flow through the bioreactor is provided, and an autosampling mechanism enables the measurement of total organic carbon, inorganic carbon and oxygen, between sample inflow and sample outflow at specified time intervals.

Abstract: Described is a new immunosuppressant, L-687,819, a C-31 demethylated derivative of L-683,795 (FK-523), produced under fermentation conditions utilizing the new mutant microorganism, Streptomyces hygroscopicus subsp. ascomyceticus (Merck Culture Collection MA 6646) ATCC No. 53855, being a blocked mutant of Streptomyces hygroscopicus subsp. ascomyceticus (MA 6475) ATCC No. 14891. The macrolide immunosuppressant is useful in preventing human host rejection of foreign organ transplants, e.g. bone marrow and heart transplants.

Abstract: A process for producing an antibiotic compound which is normally a minor component in the cultivation of Z. arboricola to be the major product is described.

Abstract: Disclosed are new Aspergillus niger mutants which can be used for identifying active FK-506/ rapamycin type, or cyclosporin A type inununosuppressants in a broth, natural product extract, or composition exhibiting inununosuppressant activity. Specifically disclosed are the new mutants, ATCC No. 74085 (MF 5659), which is sensitive to FK-506 and rapamycin but resistant to cyclosporin A; ATCC No. 74086 (MF 5659) which is resistant to FK-506, cyclosporin A and rapamycin; and ATCC No. 74087 (MF 5661) which is resistant to FK-506 and rapamycin, but sensitive to cyclosporin A.

Abstract: Compounds of Structural Formula (I) ##STR1## are produced by directed biosynthesis. These compounds are squalene synthetase inhibitors and thus useful as cholesterol lowering agents, antifungal agents and cancer treatment agents.

Abstract: Described is a new enzyme, 31-O-desmethyl-FK-506 O-methyltransferase (FKMT) and its N-terminal amino acid sequence. This enzyme can specifically and preferentially methylate the C-31 hydroxy group in 31-O-desmethyl FK-506/FR-900506 and other 31-O-desmethyl analogs of FK-506/FR-900506 and related compounds such as 31-O-desmethyl immunomycin type molecules, also designated FK-520 and FR-900520 by Fujisawa. The enzyme can be isolated from a FK-506 producing microorganism Streptomyces sp. (Merck Culture Collection No. MA 6858) ATCC No. 55098. Employing the enzyme in its active form, supplemented with Mg.sup.+2 ion, in the presence of the methyl donor, S-adenosyl methionine (SAM), derivatives of 31-O-desmethyl FK-506, 31-O-desmethyl FK-520 and related 31-O-desmethyl compounds may be prepared.

Abstract: Compounds of Structural Formula (I) ##STR1## are produced by directed biosynthesis. These compounds are squalene synthetase inhibitors useful as cholesterol-lowering agents.

Abstract: A new antibiotic cyclic lipopeptide and a method of producing it are described. The agent has very high activity against human pathogens and is of very low mammalian toxicity.

Abstract: Described is a process for producing a new immunosuppressant, a C-31 desmethyl, C-19/C-22 cyclic hemiketal biotransformation analog (Compound I) of FR-900520, under novel fermentation conditions utilizing the novel microorganism, Streptomyces, lavendulae ATCC No. 55209. Also disclosed is the C-31 methylated devivative (Compound II) of Compound I produced by enzymatic methylation using 31-O-desmethylimmunomycin O-methyl transferase, (DIMT), a methyl transferase enzyme. The macrolide immunosuppressants are useful in preventing human host rejection of foreign organ transplants, e.g. bone marrow, liver, lung, kidney and heart transplants.

Abstract: Disclosed is a novel lipophilic macrolide of Formula I: ##STR1## The compound of assigned Formula I is an analog of rapamycin which has activity as an antifungal agent and as an immunosuppressant.

Abstract: A new antibiotic cyclic lipopeptide and a method of producing it are described. The agent has very high activity against human pathogens and is of very low mammalian toxicity.

Abstract: A new antibiotic cyclic lipopeptide and a method of producing it are described. The agent has very high activity against human pathogens and is of very low mammalian toxicity.

Abstract: An antibiotic agent produced by the cultivation of Zalerion arboricola which is a cyclic lipopeptide with very high activity against human pathogens and of very low mammalian toxicity and its production and isolation are described.

Abstract: A process for the recovery of actinide and lanthanide values from aqueous acidic solutions with an organic extractant having the formula: ##STR1## where .phi. is phenyl, R.sup.1 is a straight or branched alkyl or alkoxyalkyl containing from 6 to 12 carbon atoms and R.sup.2 is an alkyl containing from 3 to 6 carbon atoms. The process is suitable for the separation of actinide and lanthanide values from fission product values found together in high level nuclear reprocessing waste solutions.

Abstract: There are disclosed certain new compounds related to C-076 compounds which have been produced by a mutant of the culture that produced the original C-076 compounds and isolated from the fermentation broth thereof. The compounds retain the C-076 16-membered cyclic backbone, however, the groups attached thereto are considerably modified from the original C-076 compounds. The new compounds have been found to retain the biological activity of the parent C-076 compounds. The compounds are thus potent antiparasitic agents and compositions and methods for such uses are also disclosed.

Abstract: A water-soluble effervescent, layered denture cleanser tablet containing one or more enzymes in one layer and one or more active oxygen compounds in the other layer and in which the enzyme layer is faster dissolving than the active oxygen layer and is substantially completely dissolved before the dissolution of the active oxygen layer reaches a level which would inactivate the enzyme.

Abstract: A storage bin is pivotly mounted relative to a housing so as to remain in a neutral position when empty and to be positioned at an angle with respect to a horizontal plane when either in a working position or in a storage position. When in the working position free access to the interior of the bin is possible since the forward end of the bin is tipped downwardly and the material in the bin is at the forward end. When in the storage position the front end of the bin is tipped upwardly with the material being at the rear of the bin. Indicating markers on the cabinet and the front end of each bin may be used when the bins are in the storage position for providing an approximation of the quantity of material in each bin.

Abstract: A technique for preparing a wide range of fulvalenes by a reductive procedure is described. The procedure involves reducing an organic halide to its corresponding partially hydrogenated derivative which is reacted with fluoboric acid to yield a fluoborate. Deprotonation of the fluoborate yields the desired compound. The described technique maximizes the yield and quality of fulvalenes produced and permits the preparation of thia, selena and tellura fulvalenes.

Abstract: The present invention discloses a system for mounting three dimensional letters on a support surface wherein at least one clip is rigidly secured to the support surface proximate a bottom edge of the letter and at least one other clip is positioned on the support surface proximate a side edge of the letter. Both clips have tongues that engage the respective edges of the letter with at least the clip on the side of the letter having a deformable tongue. With the clips properly secured to the support surface the tongue of the side clip engages the letter, for example in a hole formed therein, and then the letter is forcibly moved downwardly so that the tongue of the bottom clip engages the letter and thereby the letter itself deforms the tongue of the side clip. An obtuse angle is thus generated between the two tongues. Any one of a number of different movable clamping devices, for example such as disclosed in U.S. Pat. No. 3,749,349, may be used at the top of the letter.