Patents by Inventor Louis M. DeSantis

Louis M. DeSantis has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Use of certain isoquinolinesulfonyl compounds for the treatment of glaucoma and ocular ischemia
    Patent number: 6403590
    Abstract: Isoquinolinesulfonyl compounds are used in ophthalmic compositions to treat glaucoma or other ischemic-borne ocular disorders such as retinopathies or optic neuropathies. These compounds vasodilate ocular blood vessels, lower IOP and prevent or reduce the progression of visual field loss.
    Type: Grant
    Filed: July 31, 2001
    Date of Patent: June 11, 2002
    Assignee: Alcon Laboratories, Inc.
    Inventors: Mark R. Hellberg, Michael A. Kapin, Louis M. Desantis, Jr.
  • Use of certain isoquinolinesulfonyl compounds for the treatment of glaucoma and ocular ischemia
    Patent number: 6271224
    Abstract: The present invention relates to the field of ophthalmology. In particular the invention relates to the field of ocular disorders including visual field loss and glaucoma using an isoquinolinesulfonyl compound, which lowers intraocular pressure (IOP) and produces dilation of ocular blood vessels.
    Type: Grant
    Filed: January 19, 1999
    Date of Patent: August 7, 2001
    Assignee: Alcon Laboratories, Inc.
    Inventors: Michael A. Kapin, Louis M. Desantis, Jr.
  • Prostaglandin combinations in glaucoma therapy
    Patent number: 5565492
    Abstract: Disclosed is the use of combinations of F and E series prostaglandins and their respective derivatives and analogues, as well as pharmaceutically acceptable salts and esters thereof in the treatment of glaucoma and ocular hypertension. Also disclosed are ophthalmic, pharmaceutical compositions comprising said combinations.
    Type: Grant
    Filed: December 1, 1994
    Date of Patent: October 15, 1996
    Assignee: Alcon Laboratories, Inc.
    Inventors: Louis M. DeSantis, Verney L. Sallee
  • Use of a combination of apraclonidine and timolol to control intraocular pressure
    Patent number: 5502052
    Abstract: Ophthalmic pharmaceutical compositions useful in controlling elevated intraocular pressure associated with glaucoma and other ophthalmic conditions are described. A method of controlling elevated intraocular pressure with those compositions is also described. The compositions contain a combination of an alpha-2 agonist (e.g., para-amino clonidine) and a beta blocker (e.g., betaxolol).
    Type: Grant
    Filed: December 22, 1994
    Date of Patent: March 26, 1996
    Assignee: Alcon Laboratories, Inc.
    Inventor: Louis M. DeSantis
  • Use of lodoxamide to treat ophthalmic allergic conditions
    Patent number: 5457126
    Abstract: Disclosed are methods of using certain defined phenylene dioxamic acids in treating allergic ocular responses, such as, hayfever, conjunctivitis, atopic and keratoconjunctivitis, vernal conjunctivitis, giant capillary conjunctivitis and other diseases where mast cell degranulation are important in the etiology, by topical administration of said active to the affected eye; also disclosed are pharmaceutical compositions comprising said actives.
    Type: Grant
    Filed: March 21, 1994
    Date of Patent: October 10, 1995
    Assignee: Alcon Laboratories, Inc.
    Inventors: K. Roger Aoki, Louis M. DeSantis
  • Prostaglandin combinations in glaucoma therapy
    Patent number: 5173507
    Abstract: Disclosed is the use of combinations of the prostaglandins PGF.sub.2.alpha. and PGE.sub.2 and their respective derivatives, and pharmaceutically accceptable salts and esters thereof in the treatment of glaucoma and ocular hypertension. Also disclosed are ophthalmic, pharmaceutical compositions comprising said combinations.
    Type: Grant
    Filed: February 4, 1982
    Date of Patent: December 22, 1992
    Assignee: Alcon Laboratories, Inc.
    Inventors: Louis M. DeSantis, Verney L. Sallee
  • Use of trimoprostil and derivatives in glaucoma therapy
    Patent number: 4822819
    Abstract: Disclosed is the use of trimoprostil, and its derivatives, such as, 15-acetyl trimoprostil and pharmaceutically acceptable salts and esters thereof in the treatment of glaucoma and ocular hypertension. Also disclosed are ophthalmic, pharmaceutical compositions comprising trimoprostil and its derivatives.
    Type: Grant
    Filed: November 7, 1986
    Date of Patent: April 18, 1989
    Assignee: Alcon Laboratories, Inc.
    Inventors: Louis M. DeSantis, Verney L. Sallee
  • Use of tri-methyl PG-F.sub.2 a and derivatives in glaucoma therapy
    Patent number: 4822820
    Abstract: Disclosed is the use of Tri-methyl PG-F.sub.2 a, and its derivatives, such as, 15-acetyl Tri-methyl PG-F.sub.2 a and pharmaceutically acceptable esters thereof in the treatment of glaucoma and intraocular hypertension. Also disclosed are ophthalmic pharmaceutical compositions comprising Tri-methyl PG-F.sub.2 a and its derivatives.
    Type: Grant
    Filed: November 24, 1986
    Date of Patent: April 18, 1989
    Assignee: Alcon Laboratories, Inc.
    Inventors: Louis M. DeSantis, Verney L. Sallee
  • Control of ocular bleeding using clonidine derivatives
    Patent number: 4587257
    Abstract: A method of controlling anterior segment ocular bleeding is described. The method utilizes various clonidine derivatives (e.g., p-aminoclonidine) as the hemostatic agent.
    Type: Grant
    Filed: December 14, 1984
    Date of Patent: May 6, 1986
    Assignee: Alcon Laboratories, Inc.
    Inventors: Louis M. DeSantis, Joseph M. deFaller, Billie M. York, Jr.