Abstract: The invention concerns a sustained release formulation comprising an agent (A) which is to be released and a vehicle (B) therefor.The vehicle comprises a hydrophilic component such as a polyhydroxylated organic substance such as a polyethylene glycol, glycerol, sorbitol, mannitol or lactose and curable silicone composition which is capable of curing at ambient temperature and contains a polysiloxane having alkylhydrogen units, a polysiloxane having unsaturated groups and a platinum or rhodium catalyst. The formulation may be applied to the human or animal body or a cavity in the latter to cure in situ to give a dressing capable of sustained release of the therapeutic or diagnostic agent (A) to the body.The invention is applicable in the field of pharmacy.

Abstract: Improved pharmaceutical delivery devices which can deliver hydrophilic or polar pharmaceutically active materials, as well as optionally hydrophobic or non-polar materials, have small particles with on average a diameter below 20 microns of a drug component comprising the hydrophilic or polar pharmaceutically active material, dispersed in a silicone matrix. These devices are produced by using certain organopolysiloxane-polyoxyalkylene copolymers. Preferably an emulsion of the drug component in a silicone containing composition is made before curing the composition to an elastomer.