Patents by Inventor Louis Malspeis

Louis Malspeis has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Brefeldin A derivatives and their utility in the treatment of cancer
    Patent number: 5824674
    Abstract: Provided are brefeldin A derivatives of the formula: ##STR1## wherein one of R.sub.1 and R.sub.2 is H and the other of R.sub.1 and R.sub.2 is a substituent group having 1 to 12 carbon atoms containing a basic nitrogen atom or a quaternary ammonium group, or a salt thereof. These derivatives exhibit good antitumor activity, and are administrable to human patients without the problems associated with brefeldin A.
    Type: Grant
    Filed: November 20, 1997
    Date of Patent: October 20, 1998
    Assignees: The United States of America as represented by the Department of Health and Human Services, Starks Associates
    Inventors: Louis Malspeis, B. Rao Vishnuvajjala, Jeffrey G. Supko, Charles Theodore Kane, Jr.
  • Brefeldin A derivatives and their utility in the treatment of cancer
    Patent number: 5696154
    Abstract: Provided are brefeldin A derivatives of the formula: ##STR1## wherein one of R.sub.1 and R.sub.2 is H and the other of R.sub.1 and R.sub.2 is a substituent group having 1 to 12 carbon atoms containing a basic nitrogen atom or a quaternary ammonium group, or a salt thereof. These derivatives exhibit good antitumor activity, and are administrable to human patients without the problems associated with brefeldin A.
    Type: Grant
    Filed: June 29, 1994
    Date of Patent: December 9, 1997
    Assignees: The United States of America as represented by the Department of Health and Human Services, Starks Associates, Inc.
    Inventors: Louis Malspeis, B. Rao Vishnuvajjala, Jeffrey G. Supko, Charles Theodore Kane, Jr.