Patents by Inventor Louis-Marie Houdebine

Louis-Marie Houdebine has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Position-independent and tissue specific expression of a transgene in milk of transgenic animals
    Patent number: 7511126
    Abstract: The present invention relates to an isolated insulator DNA molecule consisting of the 5? and 3? regions of the porcine wrap gene locus and a method for insulating the expression of an introduced heterologous gene from silencing and variegation effect in chromatin into which the gene has integrated. The invention is also directed to mammalian cells comprising said insulator DNA molecule and non human animals obtained therefrom, which are preferably able to express a polypeptide of interest in milk.
    Type: Grant
    Filed: December 21, 2001
    Date of Patent: March 31, 2009
    Assignee: Institut National de la Recherche Agronomique
    Inventors: Sylvie Rival, Celine Viglietta, Joe Attal, Louis-Marie Houdebine
  • Position-independent and tissue specific expression of a transgene in milk of transgenic animals
    Publication number: 20040265806
    Abstract: The present invention relates to an isolated insulator DNA molecule consisting of the 5′ and 3′ regions of the porcine wrap gene locus and a method for insulating the expression of an introduced heterologous gene from silencing and variegation effect in chromatin into which the gene has integrated. The invention is also directed to mammalian cells comprising said insulator DNA molecule and non human animals obtained therefrom, which are preferably able to express a polypeptide of interest in milk.
    Type: Application
    Filed: June 23, 2003
    Publication date: December 30, 2004
    Inventors: Sylvie Rival, Celine Viglietta, Joe Attal, Louis-Marie Houdebine
  • Transgenic rabbit that expresses a functional human lipoprotein (a)
    Patent number: 6512161
    Abstract: A transgenic rabbit which has in its genomic DNA sequences that encode apolipoprotein (a) and apolipoprotein B polypeptides which are capable of combining to produce lipoprotein (a), a process for creating such a rabbit, and the use of the rabbit to identify compounds which are effective in the treatment of human diseases which are associated with, induced and/or exacerbated by Lp(a) expression.
    Type: Grant
    Filed: January 8, 1999
    Date of Patent: January 28, 2003
    Assignee: Aventis Pharmaceuticals, Inc.
    Inventors: Didier Rouy, Nicolas Duverger, Florence Emmanuel, Patrice Denefle, Louis-Marie Houdebine, Celine Viglietta, Edward M. Rubin, Steven D. Hughes
  • Transgenic non-human mammal comprising a rabbit WAP promoter, uses thereof, and a DNA construct comprising the rabbit WAP promoter
    Patent number: 6268545
    Abstract: A transgenic non-human mammal is provided where the genome of the mammal comprises a DNA construct comprising in operable association a rabbit WAP promoter and a DNA sequence encoding a heterologous protein. Methods of using the mammal in the production of recoverable amounts of a heterologous protein in the mammal's milk are discussed and described such that the mammal is a bio-reactor for a heterologous protein of interest. Furthermore, cells isolated from the mammal are provided for the production of a heterologous protein of interest in vitro, as well as, DNA constructs of the rabbit WAP promoter for the production of the transgenic non-human mammal.
    Type: Grant
    Filed: May 19, 1999
    Date of Patent: July 31, 2001
    Assignee: Institut National de la Recherche Agronomique
    Inventors: Louis-Marie Houdebine, Eve Devinoy, Dominique Thepot
  • Transgenic non-human mammal comprising a rabbit WAP promoter
    Patent number: 5965788
    Abstract: A transgenic non-human mammal is provided where the genome of the mammal comprises a DNA construct comprising in operable association a rabbit WAP promoter and a DNA sequence encoding a heterologous protein. Methods of using the mammal in the production of recoverable amounts of a heterologous protein in the mammal's milk are discussed and described such that the mammal is a bio-reactor for a heterologous protein of interest. Furthermore, cells isolated from the mammal are provided for the production of a heterologous protein of interest in vitro, as well as, DNA constructs of the rabbit WAP promoter for the production of the transgenic non-human mammal.
    Type: Grant
    Filed: February 10, 1994
    Date of Patent: October 12, 1999
    Assignee: Institut National de la Recherche Agronomique
    Inventors: Louis-Marie Houdebine, Eve Devinoy, Dominique Thepot
  • Dyslipoproteinaemia-sensitized transgenic rabbit
    Patent number: 5792902
    Abstract: A transgenic rabbit expressing a protein capable of interfering with dyslipoproteinaemia-related diseases, a method of preparing the same, and its use as an animal model, are disclosed. Specifically, a transgenic rabbit expressing high levels of Apo-AI, is disclosed.
    Type: Grant
    Filed: September 20, 1996
    Date of Patent: August 11, 1998
    Assignee: Rhone-Poulenc Rorer S.A.
    Inventors: Patrick Benoit, Patrice Denefle, Nicolas Duverger, Louis Marie Houdebine