Patents by Inventor Louis R. Bucalo

Louis R. Bucalo has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Publication number: 20220241186
    Abstract: The present invention provides compositions, methods, and kits for treatment of opiate addiction and pain. The invention provides a biocompatible nonerodible polymeric device which releases buprenorphine continuously with generally linear release kinetics for extended periods of time. Buprenorphine is released through pores that open to the surface of the polymeric matrix in which it is encapsulated. The device may be administered subcutaneously to an individual in need of continuous treatment with buprenorphine.
    Type: Application
    Filed: September 10, 2021
    Publication date: August 4, 2022
    Inventors: Rajesh A. PATEL, Louis R. BUCALO
  • Publication number: 20210046000
    Abstract: The present invention provides compositions, methods, and kits for treatment of opiate addiction and pain. The invention provides a biocompatible nonerodible polymeric device which releases buprenorphine continuously with generally linear release kinetics for extended periods of time. Buprenorphine is released through pores that open to the surface of the polymeric matrix in which it is encapsulated. The device may be administered subcutaneously to an individual in need of continuous treatment with buprenorphine.
    Type: Application
    Filed: March 16, 2020
    Publication date: February 18, 2021
    Inventors: Rajesh A. PATEL, Louis R. BUCALO
  • Publication number: 20190350842
    Abstract: The present invention provides compositions, methods, and kits for treatment of opiate addiction and pain. The invention provides a biocompatible nonerodible polymeric device which releases buprenorphine continuously with generally linear release kinetics for extended periods of time. Buprenorphine is released through pores that open to the surface of the polymeric matrix in which it is encapsulated. The device may be administered subcutaneously to an individual in need of continuous treatment with buprenorphine.
    Type: Application
    Filed: December 17, 2018
    Publication date: November 21, 2019
    Inventors: Rajesh A. PATEL, Louis R. BUCALO
  • Publication number: 20180177717
    Abstract: The present invention provides compositions, methods, and kits for treatment of opiate addiction and pain. The invention provides a biocompatible nonerodible polymeric device which releases buprenorphine continuously with generally linear release kinetics for extended periods of time. Buprenorphine is released through pores that open to the surface of the polymeric matrix in which it is encapsulated. The device may be administered subcutaneously to an individual in need of continuous treatment with buprenorphine.
    Type: Application
    Filed: August 3, 2017
    Publication date: June 28, 2018
    Inventors: Rajesh A. Patel, Louis R. Bucalo
  • Publication number: 20160367477
    Abstract: The present invention provides compositions, methods, and kits for treatment of opiate addiction and pain. The invention provides a biocompatible nonerodible polymeric device which releases buprenorphine continuously with generally linear release kinetics for extended periods of time. Buprenorphine is released through pores that open to the surface of the polymeric matrix in which it is encapsulated. The device may be administered subcutaneously to an individual in need of continuous treatment with buprenorphine.
    Type: Application
    Filed: May 26, 2016
    Publication date: December 22, 2016
    Inventors: Rajesh A. Patel, Louis R. Bucalo
  • Patent number: 9278163
    Abstract: The present invention provides compositions, methods, and kits for treatment of Parkinson's disease and other conditions for which treatment with a dopamine agonist is therapeutically beneficial. The invention provides a biocompatible nonerodible polymeric device which releases dopamine agonist continuously with generally linear release kinetics for extended periods of time. Dopamine agonist is released through pores that open to the surface of the polymeric matrix in which it is encapsulated. The device may be administered subcutaneously to an individual in need of continuous treatment with dopamine agonist.
    Type: Grant
    Filed: October 3, 2014
    Date of Patent: March 8, 2016
    Assignee: Titan Pharmaceuticals, Inc.
    Inventors: Rajesh A. Patel, Louis R. Bucalo, Lauren Costantini, Sofie Kleppner
  • Publication number: 20150151029
    Abstract: The present invention provides compositions, methods, and kits for treatment of Parkinson's disease and other conditions for which treatment with a dopamine agonist is therapeutically beneficial. The invention provides a biocompatible nonerodible polymeric device which releases dopamine agonist continuously with generally linear release kinetics for extended periods of time. Dopamine agonist is released through pores that open to the surface of the polymeric matrix in which it is encapsulated. The device may be administered subcutaneously to an individual in need of continuous treatment with dopamine agonist.
    Type: Application
    Filed: October 3, 2014
    Publication date: June 4, 2015
    Inventors: Rajesh A. PATEL, Louis R. BUCALO, Lauren COSTANTINI, Sofie KLEPPNER
  • Patent number: 8852623
    Abstract: The present invention provides compositions, methods, and kits for treatment of Parkinson's disease and other conditions for which treatment with a dopamine agonist is therapeutically beneficial. The invention provides a biocompatible nonerodible polymeric device which releases dopamine agonist continuously with generally linear release kinetics for extended periods of time. Dopamine agonist is released through pores that open to the surface of the polymeric matrix in which it is encapsulated. The device may be administered subcutaneously to an individual in need of continuous treatment with dopamine agonist.
    Type: Grant
    Filed: June 15, 2012
    Date of Patent: October 7, 2014
    Assignee: Titan Pharmaceuticals, Inc.
    Inventors: Rajesh A. Patel, Louis R. Bucalo, Lauren Costantini, Sofie Kleppner
  • Publication number: 20140171457
    Abstract: The present invention provides compositions, methods, and kits for treatment of opiate addiction and pain. The invention provides a biocompatible nonerodible polymeric device which releases buprenorphine continuously with generally linear release kinetics for extended periods of time. Buprenorphine is released through pores that open to the surface of the polymeric matrix in which it is encapsulated. The device may be administered subcutaneously to an individual in need of continuous treatment with buprenorphine.
    Type: Application
    Filed: November 26, 2013
    Publication date: June 19, 2014
    Applicant: Titan Pharmaceuticals, Inc.
    Inventors: Rajesh A. Patel, Louis R. Bucalo
  • Publication number: 20140163057
    Abstract: The present invention provides compositions, methods, and kits for treatment of opiate addiction and pain. The invention provides a biocompatible nonerodible polymeric device which releases buprenorphine continuously with generally linear release kinetics for extended periods of time. Buprenorphine is released through pores that open to the surface of the polymeric matrix in which it is encapsulated. The device may be administered subcutaneously to an individual in need of continuous treatment with buprenorphine.
    Type: Application
    Filed: November 26, 2013
    Publication date: June 12, 2014
    Applicant: Titan Pharmaceuticals, Inc.
    Inventors: Rajesh A. Patel, Louis R. Bucalo
  • Publication number: 20140161860
    Abstract: The present invention provides compositions, methods, and kits for treatment of opiate addiction and pain. The invention provides a biocompatible nonerodible polymeric device which releases buprenorphine continuously with generally linear release kinetics for extended periods of time. Buprenorphine is released through pores that open to the surface of the polymeric matrix in which it is encapsulated. The device may be administered subcutaneously to an individual in need of continuous treatment with buprenorphine.
    Type: Application
    Filed: November 26, 2013
    Publication date: June 12, 2014
    Applicant: Titan Pharmaceuticals, Inc.
    Inventors: Rajesh A. Patel, Louis R. Bucalo
  • Publication number: 20140088131
    Abstract: The present invention provides compositions, methods, and kits for treatment of opiate addiction and pain. The invention provides a biocompatible nonerodible polymeric device which releases buprenorphine continuously with generally linear release kinetics for extended periods of time. Buprenorphine is released through pores that open to the surface of the polymeric matrix in which it is encapsulated. The device may be administered subcutaneously to an individual in need of continuous treatment with buprenorphine.
    Type: Application
    Filed: November 26, 2013
    Publication date: March 27, 2014
    Applicant: Titan Pharmaceuticals, Inc.
    Inventors: Rajesh A. Patel, Louis R. Bucalo
  • Patent number: 8399518
    Abstract: Methods and compositions are disclosed for stimulating weight loss and/or lowering triglyceride levels in an individual mammal in need thereof. In an exemplary method, a pharmaceutical composition comprising a therapeutically effective amount of DITPA, and optionally one or more lipid-reducing agents, is administered to an individual mammal to stimulate weight loss, and/or reduce levels of triglyceride and/or lipoprotein in the mammal.
    Type: Grant
    Filed: February 27, 2008
    Date of Patent: March 19, 2013
    Assignees: University of Arizona Office of Technology Transfer, The United States of America as Represented by the Department of Veterans Affairs
    Inventors: Eugene Morkin, Louis R. Bucalo, Steven Goldman
  • Patent number: 8350486
    Abstract: Illuminated safety helmets are provided. The helmets include a shell having two or more lighted zones mounted therein, which are spaced from each other on the outer surface of the shell. One or more of the lighted zones can be selectively deactivated, allowing a wearer to control which zone or zones not to illuminate, as may be desirable in certain situations. Each zone, when activated, is illuminated in a variable fashion, such that the light illuminated from the zone changes within a brief period of time.
    Type: Grant
    Filed: January 15, 2010
    Date of Patent: January 8, 2013
    Inventor: Louis R. Bucalo
  • Publication number: 20120258161
    Abstract: The present invention provides compositions, methods, and kits for treatment of Parkinson's disease and other conditions for which treatment with a dopamine agonist is therapeutically beneficial. The invention provides a biocompatible nonerodible polymeric device which releases dopamine agonist continuously with generally linear release kinetics for extended periods of time. Dopamine agonist is released through pores that open to the surface of the polymeric matrix in which it is encapsulated. The device may be administered subcutaneously to an individual in need of continuous treatment with dopamine agonist.
    Type: Application
    Filed: June 15, 2012
    Publication date: October 11, 2012
    Inventors: Rajesh A. PATEL, Louis R. Bucalo, Lauren Costantini, Sofie Kleppner
  • Patent number: 8277342
    Abstract: A modified soccer (“football”) field layout and associated modified method of playing soccer on the modified soccer field layout are described. The modified soccer field layout is approximately the same size as a conventional soccer field layout. In one example, the modified soccer field layout also has two Forward Areas and two Forward Lines. In one example, the method of playing soccer on the modified soccer field includes at least one associated Forward Area Soccer Rule.
    Type: Grant
    Filed: November 11, 2010
    Date of Patent: October 2, 2012
    Inventor: Louis R. Bucalo
  • Publication number: 20110059819
    Abstract: A modified soccer (“football”) field layout and associated modified method of playing soccer on the modified soccer field layout are described. The modified soccer field layout is approximately the same size as a conventional soccer field layout. In one example, the modified soccer field layout also has two Forward Areas and two Forward Lines. In one example, the method of playing soccer on the modified soccer field includes at least one associated Forward Area Soccer Rule.
    Type: Application
    Filed: November 11, 2010
    Publication date: March 10, 2011
    Inventor: Louis R. Bucalo
  • Publication number: 20100304343
    Abstract: A system is provided for acquiring increased proficiency in a new or target language by enabling frequent repeated hearing and mimicking of discrete audio sound bites in the target language, wherein the sound bites and their frequency of repetition may be easily selected by the user before or during use. The sound bites may be played singly or in sequential groups or user defined groups, and automatically repeated as necessary or desired to achieve audio imprinting of the sound bites by simply listening and repeating the sounds without substantial intellectual effort or attempts at memorization. The system enables user selected or sequential hearing and mimicking of specific sound bites or groups of sound bites repeatedly in each use session in the context of meaning, without requiring dedicated language learning time, and thereby helps reproduce the natural process of initial native language acquisition which occurs without substantial intellectual effort and memorization.
    Type: Application
    Filed: June 2, 2010
    Publication date: December 2, 2010
    Inventor: Louis R. Bucalo
  • Publication number: 20100249235
    Abstract: The invention provides methods and compositions for stimulating weight loss or lowering triglyceride levels in an individual in need thereof. In methods of the invention, a pharmaceutical composition comprising a therapeutically effective amount of DITPA, and optionally one or a plurality of lipid lowering agents, is administered to an individual to stimulate weight loss, lower triglyceride and/or lipoprotein levels, and/or to treat one or more symptoms of metabolic syndrome.
    Type: Application
    Filed: February 27, 2008
    Publication date: September 30, 2010
    Applicants: TITAN PHARMACEUTICALS, INC., THE ARIZONA BOARD OF REGENTS ON BEHALF OF THE UNIVERSITY OF ARIZONA
    Inventors: Eugene Morkin, Louis R. Bucalo, Steven Goldman
  • Publication number: 20100181940
    Abstract: Illuminated safety helmets are provided. The helmets include a shell having two or more lighted zones mounted therein, which are spaced from each other on the outer surface of the shell. One or more of the lighted zones can be selectively deactivated, allowing a wearer to control which zone or zones not to illuminate, as may be desirable in certain situations. Each zone, when activated, is illuminated in a variable fashion, such that the light illuminated from the zone changes within a brief period of time.
    Type: Application
    Filed: January 15, 2010
    Publication date: July 22, 2010
    Inventor: Louis R. Bucalo