Patents by Inventor Louis S. Crocker

Louis S. Crocker has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Acid and Base Salt Forms of Gaboxadol
    Publication number: 20080262029
    Abstract: The present invention is directed to novel acid salt forms and base salt forms of the compound gabaoxadol (4,5,6,7-tetrahydroisoxazolo[5,4-c]pyridin-3-ol) and hydrates, solvates and polymorphic forms thereof. The invention is further concerned with pharmaceutical compositions containing the salt forms as an active ingredient, methods for treatment of disorders susceptible to amelioration by GABAA receptor agonism with the salt forms, and processes for the preparation of the salt forms.
    Type: Application
    Filed: April 25, 2006
    Publication date: October 23, 2008
    Applicant: H. Lundbeck A/S
    Inventors: Louis S. Crocker, Jerry A. Murry, Karthik Nagapudi, Kara Beth Rubin
  • Crystalline forms of carbapenem antibiotics and methods of preparation
    Patent number: 7145002
    Abstract: A process for preparing a crystalline, carbapenem monosodium salt of formula IIa: characterized by the steps a) adding about 10 to 30% of an organic solvent to an aqueous solution of the carbapenem, b) cooling the resulting solution to less than ?5° C., c) adjusting the pH using a solution containing an acid in an organic solvent to give the appropriate pH for crystallization, and d) crystallizing the compound by adding methanol, and a C2-5 alcohol at between ?5 and ?25° C.
    Type: Grant
    Filed: September 20, 2002
    Date of Patent: December 5, 2006
    Assignee: Merck & Co. Inc.
    Inventors: Karel M. J. Brands, Raymond Cvetovich, Louis S. Crocker, Michael D. Ward, Amar J. Mahajan, Robert M. Wenslow, John M. Williams, Daniel R. Sidler, Charles Orella, Elizabeth S. Fisher, Ronald Jobson
  • Crystal forms of (-)-6-chloro-4-cyclopropylethynyl-4-trifluoromethyl-1,4-dihydro-2H-3,1-benzoxazin-2-one
    Patent number: 6939964
    Abstract: The instant invention describes a method for crystallizing (?)-6-chloro-4-cyclopropylethynyl-4-trifluoromethyl-1,4-dihydro-2H-3,1-benzoxazin-2-one from a solvent and anti-solvent solvent system and producing the crystalline product. The desired final crystal form, Form I, can be produced when using methanol or ethanol. Form II is isolated from 2-propanol and can be converted to the desired crystal form at low drying temperatures, such as between about a temperature of 40° C. and 50° C.
    Type: Grant
    Filed: June 24, 2004
    Date of Patent: September 6, 2005
    Assignee: Merck & Co., Inc.
    Inventors: Louis S. Crocker, Joseph L. Kukura, II, Andrew S. Thompson, Christine Stelmach, Steven D. Young
  • Polymorphic, amorphous and hydrated forms of 5-chloro-3-(4-methanesulfonylphenyl)-6?-methyl-[2,3?]bipyridinyl
    Patent number: 6858631
    Abstract: Polymorphic, amorphous and hydrated forms of the title compound having the following structure: are disclosed. The compound is a potent and selective cyclooxygenase-2 (COX-2)inhibitor.
    Type: Grant
    Filed: September 12, 2003
    Date of Patent: February 22, 2005
    Assignee: Merck & Co., Inc.
    Inventors: Louis S. Crocker, Dongwei Cai
  • Crystal forms of (-)-6-chloro-4-cyclopropylethynyl-4-trifluoromethyl-1,4-dihydro-2H-3,1-benzoxazin-2-one
    Publication number: 20040259872
    Abstract: The instant invention describes a method for crystallizing (−)-6-chloro-4-cyclopropylethynyl-4-trifluoromethyl-1,4-dihydro-2H-3,1-benzoxazin-2-one from a solvent and anti-solvent solvent system and producing the crystalline product. The desired final crystal form, Form I, can be produced when using methanol or ethanol. Form II is isolated from 2-propanol and can be converted to the desired crystal form at low drying temperatures, such as between about a temperature of 40° C. and 50° C.
    Type: Application
    Filed: June 24, 2004
    Publication date: December 23, 2004
    Inventors: Louis S. Crocker, Joseph L. Kukura, Andrew S. Thompson, Christine Stelmach, Steven D. Young
  • Crystalline forms of ertapenem sodium
    Publication number: 20040235817
    Abstract: A process for preparing a crystalline, carbapenem monosodium salt of formula IIa: 1
    Type: Application
    Filed: January 27, 2004
    Publication date: November 25, 2004
    Inventors: Karel M. J. Brands, Raymond Cvetovich, Louis S Crocker, Michael D Ward, Amar J Mahajan, Robert M Wenslow, John M Williams, Daniel R Sidler, Charles Orella, Elizabeth S Fisher
  • 5-chloro-3-(4-methanesulfonylphenyl)-6?-methyl-[2,3?]bipyridinyl in pure crystalline form and process for synthesis
    Patent number: 6673935
    Abstract: This invention encompasses the Form V polymorph of Compound A of structural formula: which is useful in the treatment of cyclooxygenase-2 mediated diseases. The invention encompasses certain pharmaceutical compositions for treatment of cyclooxygenase-2 mediated diseases comprising the Form V polymorph of Compound A. The invention also encompasses a process for synthesizing the Form V polymorph of Compound A.
    Type: Grant
    Filed: January 14, 2003
    Date of Patent: January 6, 2004
    Assignee: Merck & Co., Inc.
    Inventors: Louis S. Crocker, Ian W. Davies, Richard G. Osifchin, Andrew Kotliar
  • Crystal forms of (-)-6-chloro-4-cyclopropylethynyl-4-trifluoromethyl-1,4-dihydro-2H-3,1-benzoxazin-2-one
    Publication number: 20030208070
    Abstract: The instant invention describes a method for crystallizing (−)-6-chloro-4-cyclopropylethynyl-4-trifluoromethyl-1,4-dihydro-2H-3,1-benzoxazin-2-one from a solvent and anti-solvent solvent system and producing the crystalline product. The desired final crystal form, Form I, can be produced when using methanol or ethanol. Form II is isolated from 2-propanol and can be converted to the desired crystal form at low drying temperatures, such as between about a temperature of 40° C. and 50° C.
    Type: Application
    Filed: May 29, 2003
    Publication date: November 6, 2003
    Inventors: Louis S. Crocker, Joseph L. Kukura, Andrew S. Thompson, Christine Stelmach, Steven D. Young
  • Crystal Forms of (-)-6-chloro-4-cyclopropylethynyl-4-trifluoromethyl-1,4-dihydro-2H-3,1-benzoxazin-2-one
    Patent number: 6639071
    Abstract: The instant invention describes a method for crystallizing (−)-6-chloro-4-cyclopropylethynyl-4-trifluoromethyl-1,4-dihydro-2H-3,1-benzoxazin-2-one from a solvent and anti-solvent system and producing the crystalline product. The desired final crystal form, Form I, can be produced when using methanol or ethanol. Form II is isolated from 2-propanol and can be converted to the desired crystal form at low drying temperatures, such as between about a temperature of 40° C. and 50° C.
    Type: Grant
    Filed: October 19, 2001
    Date of Patent: October 28, 2003
    Assignee: Merck & Co., Inc.
    Inventors: Louis S. Crocker, Joseph L. Kukura, II, Andrew S. Thompson, Christine Stelmach, Steven D. Young
  • 5-chloro-3-(4-methanesulfonylphenyl)-6'-methyl-[2,3']bipyridinyl in pure crystalline form and process for synthesis
    Publication number: 20030153600
    Abstract: This invention encompasses the Form V polymorph of Compound A of structural formula: 1
    Type: Application
    Filed: January 14, 2003
    Publication date: August 14, 2003
    Applicant: Merck & Co., Inc.
    Inventors: Louis S. Crocker, Ian W. Davies, Richard G. Osifchin, Andrew Kotliar
  • Polymorphic, amorphous and hydrated forms of 5-chloro-3-(4-methanesulfonylphenyl)-6'-methyl-[2,3']bipyridinyl
    Publication number: 20030144327
    Abstract: Polymorphic, amorphous and hydrated forms of the title compound having the following structure: 1
    Type: Application
    Filed: January 14, 2003
    Publication date: July 31, 2003
    Applicant: Merck & Co., Inc.
    Inventor: Louis S. Crocker
  • 4-Benzyl-2-hydroxy-1,4-oxazine-3-one and polymorphic forms thereof
    Patent number: 6538134
    Abstract: The present invention is concerned with 4-benzyl-2-hydroxy-1,4-oxazin-3-one, and novel processes for the preparation therof. This compound is useful as an intermediate in the synthesis of compounds which possess pharmacological activity.
    Type: Grant
    Filed: June 8, 2001
    Date of Patent: March 25, 2003
    Assignee: Merck & Co., Inc.
    Inventors: Louis S. Crocker, Karel M. Jos Brands, Todd D. Nelson, Philip J. Pye, Jonathan D. Rosen, Kai Rossen
  • 5-chloro-3-(4-methanesulfonylphenyl)-6?-methyl-[2,3?]bipyridinyl in pure crystalline form and process for synthesis
    Patent number: 6521642
    Abstract: This invention encompasses the Form V polymorph of Compound A of structural formula: which is useful in the treatment of cyclooxygenase-2 mediated diseases. The invention encompasses certain pharmaceutical compositions for treatment of cyclooxygenase-2 mediated diseases comprising the Form V polymorph of Compound A. The invention also encompasses a process for synthesizing the Form V polymorph of Compound A.
    Type: Grant
    Filed: May 25, 2001
    Date of Patent: February 18, 2003
    Assignee: Merck & Co., Inc.
    Inventors: Louis S. Crocker, Ian W. Davies, Richard G. Osifchin, Andrew Kotliar
  • Polymorphic, amorphous and hydrated forms of 5-chloro-3-(4-methanesulfonylphenyl)-6'-methyl-[2,3']bipyridinyl
    Publication number: 20020198238
    Abstract: Polymorphic, amorphous and hydrated forms of the title compound having the following structure: 1
    Type: Application
    Filed: June 26, 2002
    Publication date: December 26, 2002
    Applicant: Merck & Co., Inc.
    Inventor: Louis S. Crocker
  • Polymorphic, amorphous and hydrated forms of 5-chloro-3-(4-methanesulfonyphenyl)-6'- methyl-[2,3']bipyridinyl
    Patent number: 6441002
    Abstract: Polymorphic, amorphous and hydrated forms of the title compound having the following structure: are disclosed. The compound is a potent and selective cyclooxygenase-2 (COX-2) inhibitor.
    Type: Grant
    Filed: November 28, 2000
    Date of Patent: August 27, 2002
    Assignees: Merck & Co., Inc., Merck Frosst Canada & Co.
    Inventors: Sophie Dorothee Clas, Louis S. Crocker, James A. McCauley, Ian Davies, Chad Dalton
  • Process for the crystallization of a reverse transcriptase inhibitor using an anti-solvent
    Publication number: 20020115664
    Abstract: The instant invention describes a method for crystallizing (−)-6-chloro-4-cyclopropylethynyl-4-trifluoromethyl-1,4-dihydro-2H-3,1-benzoxazin-2-one from a solvent and anti-solvent solvent system and producing the crystalline product. The desired final crystal form, Form I, can be produced when using methanol or ethanol. Form II is isolated from 2-propanol and can be converted to the desired crystal form at low drying temperatures, such as between about a temperature of 40° C. and 50° C.
    Type: Application
    Filed: October 19, 2001
    Publication date: August 22, 2002
    Inventors: Louis S. Crocker, William F. Clarke, Joseph L. Kukura, Andrew S. Thompson
  • 4-Benzyl-2-hydroxy-1, 4-oxazine-3-one and polymorphic forms thereof
    Publication number: 20020042510
    Abstract: The present invention is concerned with 4-benzyl-2-hydroxy-1,4-oxazin-3-one, and novel processes for the preparation therof. This compound is useful as an intermediate in the synthesis of compounds which possess pharmacological activity.
    Type: Application
    Filed: June 8, 2001
    Publication date: April 11, 2002
    Inventors: Louis S. Crocker, Karel M. Jos Brands, Todd D. Nelson, Philip J. Pye, Jonathan D. Rosen, Kai Rossen
  • 5-chloro-3-(4-methanesulfonylphenyl)-6'-methyl-[2,3']bipyridinyl in pure crystalline form and process for synthesis
    Publication number: 20020016343
    Abstract: This invention encompasses the Form V polymorph of Compound A of structural formula: 1
    Type: Application
    Filed: May 25, 2001
    Publication date: February 7, 2002
    Inventors: Louis S. Crocker, Ian W. Davies, Richard G. Osifchin, Andrew Kotliar
  • PROCESS FOR THE CRYSTALLIZATION OF A REVERSE TRANSCRIPTASE INHIBITOR USING AN ANTI-SOLVENT
    Publication number: 20010016653
    Abstract: The instant invention describes a method for crystallizing (−)-6-chloro-4-cyclopropylethynyl-4-trifluoromethyl-1,4-dihydro-2H-3,1-benzoxazin-2-one from a solvent and anti-solvent solvent system and producing the crystalline product. The desired final crystal form, Form I, can be produced when using methanol or ethanol. Form II is isolated from 2-propanol and can be converted to the desired crystal form at low drying temperatures, such as between about a temperature of 40° C. and 50° C.
    Type: Application
    Filed: March 31, 1999
    Publication date: August 23, 2001
    Inventors: LOUIS S. CROCKER, JOSEPH L. KUKURA
  • Crystalline forms of carbapenem antibiotics and methods of preparation
    Patent number: RE40794
    Abstract: A process for preparing a crystalline, carbapenem monosodium salt of formula IIa: characterized by the steps a) adding about 10 to 30% of an organic solvent to an aqueous solution of the carbapenem, b) cooling the resulting solution to less than ?5° C., c) adjusting the pH using a solution containing an acid in an organic solvent to give the appropriate pH for crystallization, and d) crystallizing the compound by adding methanol, and a C2-5 alcohol at between ?5 and ?25° C.
    Type: Grant
    Filed: September 20, 2002
    Date of Patent: June 23, 2009
    Assignee: Merck & Co., Inc.
    Inventors: Karel M. J. Brands, Raymond Cvetovich, Louis S. Crocker, Michael D. Ward, Amar J. Mahajan, Robert M. Wenslow, John M. Williams, Daniel R. Sidler, Charles Orella, Elizabeth S. Fisher, Ronald Jobson