Patents by Inventor Louis Thomas Germinario
Louis Thomas Germinario has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Publication number: 20230330362Abstract: A dry powder aerosol delivery device and related methods for delivering precise and repeatable dosages to a subject for pulmonary use is disclosed. The dry powder aerosol delivery device includes a housing, a cartridge, and a dry powder dispersion mechanism, and at least one differential pressure sensor. The dry powder delivery device is automatically breath actuated by the user when the differential pressure sensor senses a predetermined pressure change within housing. The dry powder aerosol delivery device is then actuated to generate a plume of particles having an average ejected particle diameter within the respirable size range, e.g., less than about 5-6 ?m, so as to target the pulmonary system of the user.Type: ApplicationFiled: December 13, 2022Publication date: October 19, 2023Applicant: PNEUMA RESPIRATORY, INC.Inventors: Charles Eric Hunter, John H. Hebrank, Louis Thomas Germinario
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Patent number: 11771852Abstract: A droplet delivery device with a small volume drug ampoule and related methods for delivering precise and repeatable dosages to a subject for pulmonary use is disclosed. The droplet delivery device is configured to facilitate the ejection of small, e.g., single use, volumes of a therapeutic agent. The droplet delivery device includes a housing, a mouthpiece, a small volume drug ampoule, an ejector mechanism, and at least one differential pressure sensor. The delivery device is automatically breath actuated by the user when the differential pressure sensor senses a predetermined pressure change within housing. The droplet delivery device is then actuated to generate a plume of droplets having an average ejected particle diameter within the respirable size range, e.g, less than about 5-6 ?m, so as to target the pulmonary system of the user.Type: GrantFiled: November 8, 2018Date of Patent: October 3, 2023Assignee: PNEUMA RESPIRATORY, INC.Inventors: John H. Hebrank, Christopher W. Maurer, Charles Eric Hunter, Chengjie Li, Louis Thomas Germinario
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Publication number: 20230277781Abstract: A device and method for delivering a fluid as an ejected stream of droplets during inhalation uses inertial filtering to cause a first plurality of droplet particles generated by an ejector mechanism to pass through an airflow exit while a second plurality of droplet particles having a greater mass mean aerodynamic diameter than the first plurality of droplet particles fails to pass through the airflow exit.Type: ApplicationFiled: February 15, 2023Publication date: September 7, 2023Applicant: PNEUMA RESPIRATORY, INC.Inventors: Louis Thomas Germinario, John H. Hebrank, Charles Eric Hunter, Jack C. Hunter, Chengjie Li, Christopher W. Maurer
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Patent number: 11738158Abstract: An in-line droplet delivery device and related methods for delivering precise and repeatable dosages to a subject for pulmonary use is disclosed. The in-line droplet delivery device includes a housing, a mouthpiece, a reservoir, an ejector mechanism, and at least one differential pressure sensor. The in-line droplet delivery device is automatically breath actuated by the user when the differential pressure sensor senses a predetermined pressure change within housing. The in-line droplet delivery device is then actuated to generate a plume of droplets having an average ejected particle diameter within the respirable size range, e.g, less than about 5-6 ?m, so as to target the pulmonary system of the user. the droplet delivery device is configured in an in-line orientation in that the housing, its internal components, and various device components (e.g., the mouthpiece, air inlet flow element, etc.) are orientated in a substantially in-line or parallel configuration (e.g.Type: GrantFiled: October 4, 2018Date of Patent: August 29, 2023Assignee: Pneuma Respiratory, Inc.Inventors: John H. Hebrank, Charles Eric Hunter, Christopher W. Maurer, Chengjie Li, Louis Thomas Germinario
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Publication number: 20230127529Abstract: A nasal droplet delivery device and related methods for delivering precise and repeatable dosages to a subject via the nasal passageways and sinus cavities.Type: ApplicationFiled: September 30, 2022Publication date: April 27, 2023Applicant: PNEUMA RESPRIATORY, INCInventors: John H. Hebrank, Christopher W. Maurer, Charles Eric Hunter, Chengjie Li, Louis Thomas Germinario
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Patent number: 11529476Abstract: A dry powder aerosol delivery device and related methods for delivering precise and repeatable dosages to a subject for pulmonary use is disclosed. The dry powder aerosol delivery device includes a housing, a cartridge, and a dry powder dispersion mechanism, and at least one differential pressure sensor. The dry powder delivery device is automatically breath actuated by the user when the differential pressure sensor senses a predetermined pressure change within housing. The dry powder aerosol delivery device is then actuated to generate a plume of particles having an average ejected particle diameter within the respirable size range, e.g., less than about 5-6 ?m, so as to target the pulmonary system of the user.Type: GrantFiled: May 21, 2018Date of Patent: December 20, 2022Assignee: Pneuma Respiratory, Inc.Inventors: Charles Eric Hunter, John H. Hebrank, Louis Thomas Germinario
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Publication number: 20220355329Abstract: An ejector device for ejecting droplets of fluid onto a surface includes an ejector mechanism attached to a fluid reservoir through a fluid loading plate that is configured to pierce the reservoir and channel the fluid to a rear surface of the ejector mechanism by capillary action. The ejector mechanism may have a centro-symmetric configuration with a lead free piezo actuator and may be covered by an auto-closing cover.Type: ApplicationFiled: March 25, 2022Publication date: November 10, 2022Inventors: Jonathan Ryan Wilkerson, Iyam Lynch, Charles Eric Hunter, Joshua Richard Brown, Louis Thomas Germinario, James Thornhill Leath, Nathan R. Faulks, Kris Grube, Matthew Ditrolio, J. Sid Clements
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Patent number: 11458267Abstract: A nasal droplet delivery device and related methods for delivering precise and repeatable dosages to a subject via the nasal passageways and sinus cavities is disclosed. The droplet delivery device includes a housing, a nosepiece, a reservoir, an ejector mechanism, and at least one differential pressure sensor. The droplet delivery device is automatically actuated by the user when the differential pressure sensor senses a predetermined pressure change within the nosepiece. The droplet delivery device is then actuated to generate a plume of droplets having an average ejected particle diameter of greater than about 6 microns, preferably greater than about 10 micron, so as to target the nasal passageways and sinus cavities of the user.Type: GrantFiled: October 17, 2018Date of Patent: October 4, 2022Assignee: PNEUMA RESPIRATORY, INC.Inventors: John H. Hebrank, Christopher W. Maurer, Charles Eric Hunter, Chengjie Li, Louis Thomas Germinario
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Patent number: 11285284Abstract: A droplet delivery device and related methods for delivering precise and repeatable dosages to a subject for pulmonary use is disclosed. The droplet delivery device includes a housing, a reservoir, and ejector mechanism, and at least one differential pressure sensor. The droplet delivery device is automatically breath actuated by the user when the differential pressure sensor senses a predetermined pressure change within housing. The droplet delivery device is then actuated to generate a stream of droplets having an average ejected droplet diameter within the respirable size range, e.g, less than about 5 ?m, so as to target the pulmonary system of the user.Type: GrantFiled: May 3, 2017Date of Patent: March 29, 2022Assignee: Pneuma Respiratory, Inc.Inventors: Louis Thomas Germinario, John H. Hebrank, Charles Eric Hunter, Thomas P. Stern
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Patent number: 11285274Abstract: A droplet delivery device and related methods for delivering precise and repeatable dosages to a subject for pulmonary use is disclosed. The droplet delivery device includes a housing, a reservoir, and ejector mechanism, and at least one differential pressure sensor. The droplet delivery device is automatically breath actuated by the user when the differential pressure sensor senses a predetermined pressure change within housing. The droplet delivery device is then actuated to generate a stream of droplets having an average ejected droplet diameter within the respirable size range, e.g, less than about 5 ?m, so as to target the pulmonary system of the user.Type: GrantFiled: May 3, 2017Date of Patent: March 29, 2022Assignee: Pneuma Respiratory, Inc.Inventors: Louis Thomas Germinario, John H. Hebrank, Charles Eric Hunter, Thomas P. Stern
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Patent number: 11285285Abstract: A droplet delivery device and related methods for delivering precise and repeatable dosages to a subject for pulmonary use is disclosed. The droplet delivery device includes a housing, a reservoir, and ejector mechanism, and at least one differential pressure sensor. The droplet delivery device is automatically breath actuated by the user when the differential pressure sensor senses a predetermined pressure change within housing. The droplet delivery device is then actuated to generate a stream of droplets having an average ejected droplet diameter within the respirable size range, e.g, less than about 5 ?m, so as to target the pulmonary system of the user.Type: GrantFiled: May 3, 2017Date of Patent: March 29, 2022Assignee: Pneuma Respiratory, Inc.Inventors: Louis Thomas Germinario, John H. Hebrank, Charles Eric Hunter, Thomas P. Stern, Jack C. Hunter
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Patent number: 11285283Abstract: A droplet delivery device and related methods for delivering precise and repeatable dosages to a subject for pulmonary use is disclosed. The droplet delivery device includes a housing, a reservoir, and ejector mechanism, and at least one differential pressure sensor. The droplet delivery device is automatically breath actuated by the user when the differential pressure sensor senses a predetermined pressure change within housing. The droplet delivery device is then actuated to generate a stream of droplets having an average ejected droplet diameter within the respirable size range, e.g, less than about 5 ?m, so as to target the pulmonary system of the user.Type: GrantFiled: May 3, 2017Date of Patent: March 29, 2022Assignee: Pneuma Respiratory, Inc.Inventors: Louis Thomas Germinario, John H. Hebrank, Charles Eric Hunter, Jack C. Hunter, Chengjie Li, Christopher W. Maurer
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Patent number: 11285504Abstract: An ejector device for ejecting droplets of fluid onto a surface includes an ejector mechanism attached to a fluid reservoir through a fluid loading plate that is configured to pierce the reservoir and channel the fluid to a rear surface of the ejector mechanism by capillary action. The ejector mechanism may have a centro-symmetric configuration with a lead free piezo actuator and may be covered by an auto-closing cover.Type: GrantFiled: June 29, 2016Date of Patent: March 29, 2022Assignee: Eyenovia, Inc.Inventors: Jonathan Ryan Wilkerson, Iyam Lynch, Charles Eric Hunter, Joshua Richard Brown, Louis Thomas Germinario, James Thornhill Leath, Nathan R. Faulks, Kris Grube, Matthew Ditrolio, J. Sid Clements
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Publication number: 20220008669Abstract: A droplet delivery device and related methods for delivering precise and repeatable dosages to a subject for pulmonary use is disclosed. The droplet delivery device includes a housing, a reservoir, and ejector mechanism, and at least one differential pressure sensor. The droplet delivery device is automatically breath actuated by the user when the differential pressure sensor senses a predetermined pressure change within housing. The droplet delivery device is then actuated to generate a stream of droplets having an average ejected droplet diameter within the respirable size range, e.g, less than about 5 ?m, so as to target the pulmonary system of the user.Type: ApplicationFiled: January 22, 2021Publication date: January 13, 2022Applicant: Pneuma Respiratory, Inc.Inventors: Louis Thomas Germinario, John H. Hebrank, Charles Eric Hunter, Jack C. Hunter, Chengjie Li, Christopher W. Maurer
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Publication number: 20210236745Abstract: A droplet delivery device and related methods for delivering precise and repeatable dosages to a subject for pulmonary use is disclosed. The droplet delivery device includes a housing, a reservoir, and ejector mechanism, and at least one differential pressure sensor. The droplet delivery device is automatically breath actuated by the user when the differential pressure sensor senses a predetermined pressure change within housing. The droplet delivery device is then actuated to generate a stream of droplets having an average ejected droplet diameter within the respirable size range, e.g, less than about 5 ?m, so as to target the pulmonary system of the user.Type: ApplicationFiled: May 3, 2017Publication date: August 5, 2021Applicant: PNEUMA RESPIRATORY, INC.Inventors: Louis Thomas Germinario, John H. Hebrank, Charles Eric Hunter, Jack C. Hunter, Chengjie Li, Christopher W. Maurer
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Patent number: 10898666Abstract: A droplet delivery device and related methods for delivering precise and repeatable dosages to a subject for pulmonary use is disclosed. The droplet delivery device includes a housing, a reservoir, and ejector mechanism, and at least one differential pressure sensor. The droplet delivery device is automatically breath actuated by the user when the differential pressure sensor senses a predetermined pressure change within housing. The droplet delivery device is then actuated to generate a stream of droplets having an average ejected droplet diameter within the respirable size range, e.g, less than about 5 ?m, so as to target the pulmonary system of the user.Type: GrantFiled: March 2, 2018Date of Patent: January 26, 2021Assignee: Pneuma Respiratory, Inc.Inventors: Louis Thomas Germinario, John H. Hebrank, Charles Eric Hunter, Jack C. Hunter, Chengjie Li, Christopher W. Maurer
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Publication number: 20200353186Abstract: A droplet delivery device with a small volume drug ampoule and related methods for delivering precise and repeatable dosages to a subject for pulmonary use is disclosed. The droplet delivery device is configured to facilitate the ejection of small, e.g., single use, volumes of a therapeutic agent. The droplet delivery device includes a housing, a mouthpiece, a small volume drug ampoule, an ejector mechanism, and at least one differential pressure sensor. The delivery device is automatically breath actuated by the user when the differential pressure sensor senses a predetermined pressure change within housing. The droplet delivery device is then actuated to generate a plume of droplets having an average ejected particle diameter within the respirable size range, e.g, less than about 5-6 ?m, so as to target the pulmonary system of the user.Type: ApplicationFiled: November 8, 2018Publication date: November 12, 2020Applicant: PNEUMA RESPIRATORY, INC.Inventors: John H. Hebrank, Christopher W. Mauer, Charles Eric Hunter, Chengjie LI, Louis Thomas Germinario
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Publication number: 20200289770Abstract: A nasal droplet delivery device and related methods for delivering precise and repeatable dosages to a subject via the nasal passageways and sinus cavities is disclosed. The droplet delivery device includes a housing, a nosepiece, a reservoir, an ejector mechanism, and at least one differential pressure sensor. The droplet delivery device is automatically actuated by the user when the differential pressure sensor senses a predetermined pressure change within the nosepiece. The droplet delivery device is then actuated to generate a plume of droplets having an average ejected particle diameter of greater than about 6 microns, preferably greater than about 10 micron, so as to target the nasal passageways and sinus cavities of the user.Type: ApplicationFiled: October 17, 2018Publication date: September 17, 2020Applicant: PNEUMA RESPIRATORY, INC.Inventors: John H. Hebrank, Christopher W. Maurer, Charles Eric Hunter, Chengjie Li, Louis Thomas Germinario
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Publication number: 20200276398Abstract: An in-line droplet delivery device and related methods for delivering precise and repeatable dosages to a subject for pulmonary use is disclosed. The in-line droplet delivery device includes a housing, a mouthpiece, a reservoir, an ejector mechanism, and at least one differential pressure sensor. The in-line droplet delivery device is automatically breath actuated by the user when the differential pressure sensor senses a predetermined pressure change within housing. The in-line droplet delivery device is then actuated to generate a plume of droplets having an average ejected particle diameter within the respirable size range, e.g, less than about 5-6 ?m, so as to target the pulmonary system of the user. the droplet delivery device is configured in an in-line orientation in that the housing, its internal components, and various device components (e.g., the mouthpiece, air inlet flow element, etc.) are orientated in a substantially in-line or parallel configuration (e.g.Type: ApplicationFiled: October 4, 2018Publication date: September 3, 2020Applicant: PNEUMA RESPIRATORY, INC.Inventors: John H. Hebrank, Charles Eric Hunter, Christopher W. Maurer, Chengjie Li, Louis Thomas Germinario
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Patent number: 10646373Abstract: An ejector device and method of delivering safe, suitable, and repeatable dosages to a subject for topical, oral, nasal, or pulmonary use is disclosed. The ejector device includes a housing, a reservoir disposed within the housing for receiving a volume of fluid, and an ejector mechanism in fluid communication with the reservoir and configured to eject a stream of droplets, the ejector mechanism comprising an ejector plate coupled to a generator plate and a piezoelectric actuator; the piezoelectric actuator being operable to oscillate the ejector plate, and thereby the generator plate, at a frequency and generate a directed stream of droplets.Type: GrantFiled: August 16, 2017Date of Patent: May 12, 2020Assignee: Eyenovia, Inc.Inventors: Charles Eric Hunter, Louis Thomas Germinario, Jonathan Ryan Wilkerson, Iyam Lynch, Joshua Richard Brown