Abstract: An example method of cycling electric stimulation includes delivering, via an implantable device, electric stimulation to a patient in accordance with a first therapy program; monitoring, via the implantable device and while the electric stimulation is being delivered in accordance with the first therapy program, a biomarker; and responsive to determining the biomarker satisfies a threshold, delivering, via the implantable device, electric stimulation to the patient in accordance with a second therapy program that is different than the first therapy program.

Abstract: A system comprises a bendable, pre-formed lead body operable to be implanted proximate a neural pathway of a patient. A first electrode comprising a plurality of first segments at a first longitudinal location of the lead body is configured to be positioned at a lateral epidural region proximate at least one nerve root of the patient, and a second electrode comprising a plurality of second segments at a second longitudinal location of the lead body is configured to be positioned along a midline of the patient's spinal column. The system further includes a signal generator electrically coupled to at least one of the first and second electrodes and a processor coupled to the signal generator and operable to apply a stimulation signal to at least one of the first and second electrodes.

Abstract: A system comprises a bendable, pre-formed lead body operable to be implanted proximate a neural pathway of a patient. A first electrode comprising a plurality of first segments at a first longitudinal location of the lead body is configured to be positioned at a lateral epidural region proximate at least one nerve root of the patient, and a second electrode comprising a plurality of second segments at a second longitudinal location of the lead body is configured to be positioned along a midline of the patient's spinal column. The system further includes a signal generator electrically coupled to at least one of the first and second electrodes and a processor coupled to the signal generator and operable to apply a stimulation signal to at least one of the first and second electrodes.

Abstract: An example system includes a stimulation generator configured to deliver electrical stimulation therapy to tissue of a patient in accordance with a stimulation therapy program. The stimulation therapy program may include a set of stimulation therapy parameters. The system may include at least one sensor configured to detect a signal including an evoked compound muscle action potential (eCMAP) in response to the application of stimulation according to the stimulation therapy program. The system may also include a processor configured to adjust one or more or the stimulation therapy parameters based on the detected signal that includes the eCMAP.

Abstract: In some examples, a method may include delivering an electrical stimulation therapy to a patient, the electrical stimulation therapy comprising a first electrical stimulation pulse delivered to the patient via a first electrode and a second electrical stimulation pulse delivered to the patient via a second electrode, wherein the first electrical stimulation pulse and second electrical stimulation pulse are delivered as paired pulses with respect to each other and a combination of the first electrical stimulation pulse and the second electrical stimulation pulse evoke a compound action potential within the patient; sensing the compound action potential evoked by the combination of the first electrical stimulation pulse and the second electrical stimulation pulse; and adjusting one or more parameters of the electrical stimulation therapy based on the sensed compound action potential.

Abstract: In some examples, a method may include delivering an electrical stimulation therapy to a patient, the electrical stimulation therapy comprising a first electrical stimulation pulse delivered to the patient via a first electrode and a second electrical stimulation pulse delivered to the patient via a second electrode, wherein the first electrical stimulation pulse and second electrical stimulation pulse are delivered as paired pulses with respect to each other and a combination of the first electrical stimulation pulse and the second electrical stimulation pulse evoke a compound action potential within the patient; sensing the compound action potential evoked by the combination of the first electrical stimulation pulse and the second electrical stimulation pulse; and adjusting one or more parameters of the electrical stimulation therapy based on the sensed compound action potential

Abstract: In some examples, a method may include delivering an electrical stimulation therapy to a patient, the electrical stimulation therapy comprising a first electrical stimulation pulse delivered to the patient via a first electrode and a second electrical stimulation pulse delivered to the patient via a second electrode, wherein the first electrical stimulation pulse and second electrical stimulation pulse are delivered as paired pulses with respect to each other and a combination of the first electrical stimulation pulse and the second electrical stimulation pulse evoke a compound action potential within the patient; sensing the compound action potential evoked by the combination of the first electrical stimulation pulse and the second electrical stimulation pulse; and adjusting one or more parameters of the electrical stimulation therapy based on the sensed compound action potential.

Abstract: This disclosure relates to methods, devices, and systems for delivering and adjusting stimulation therapy. In one example, a system may include a stimulation generator configured to delivery electrical stimulation therapy to tissue of a patient in accordance with a stimulation therapy program. The stimulation therapy program may include a set of stimulation therapy parameters. The system may include at least one sensor configured to detect a signal including an evoked compound muscle action potential (eCMAP) in response to the application of stimulation according to the stimulation therapy program. The system may also include a processor configured to adjust one or more or the stimulation therapy parameters based on the detected signal that includes the eCMAP.

Abstract: In some examples, a method may include delivering an electrical stimulation therapy to a patient, the electrical stimulation therapy comprising a first electrical stimulation pulse delivered to the patient via a first electrode and a second electrical stimulation pulse delivered to the patient via a second electrode, wherein the first electrical stimulation pulse and second electrical stimulation pulse are delivered as paired pulses with respect to each other and a combination of the first electrical stimulation pulse and the second electrical stimulation pulse evoke a compound action potential within the patient; sensing the compound action potential evoked by the combination of the first electrical stimulation pulse and the second electrical stimulation pulse; and adjusting one or more parameters of the electrical stimulation therapy based on the sensed compound action potential