Abstract: This invention is in the area of improved anti-aP2 antibodies and antigen binding agents, and compositions thereof, which target the lipid chaperone aP2/FABP4 (referred to as “aP2”) for use in treating disorders such as diabetes, obesity, cardiovascular disease, fatty liver disease, and/or cancer, among others. In one aspect, improved treatments for aP2 mediated disorders are disclosed in which serum aP2 is targeted and the biological activity of aP2 is neutralized or modulated using low-binding affinity aP2 monoclonal antibodies, providing lower fasting blood glucose levels, improved systemic glucose metabolism, increased systemic insulin sensitivity, reduced fat mass, reduced liver steatosis, reduced cardiovascular disease and/or a reduced risk of developing cardiovascular disease.

Abstract: A garment includes a connected front and back panels forming a cavity for an upper body of a subject. Each of a pair of sleeves is connected to at least one of the front or back panel and is in communication with the cavity. A collar is configured to surround a neck of the subject. Each of a pair of shoulder straps is connected at one end to the collar and at an opposing end to at least one of the front or back panels or a sleeve. A first opening is formed by at least the straps, a top edge of the front panel, and the collar to expose a top portion of the subject's chest. A second opening is formed by at least the straps, a top edge of the back panel, and the collar to expose a top portion of the subject's back.

Abstract: There is a system for secure use of a wheelchair in demand response transportation systems comprising a wheelchair restraint comprising a central housing, and a wheelchair strap, extending from the central housing, to secure the wheelchair restraint to the wheelchair, and a wheelchair strap sensor configured to provide a wheelchair strap sensor signal indicating whether the wheelchair strap is securely connected to a wheelchair via the wheelchair strap.

Abstract: There is a system for secure use of a wheelchair in demand response transportation systems comprising a wheelchair restraint comprising a central housing disposed between a vehicle strap and a wheelchair strap, the vehicle strap to secure the wheelchair restraint to the demand response vehicle, further comprising a vehicle strap sensor configured to provide a vehicle strap sensor electrical signal indicating whether the vehicle strap is securely affixed to a wheelchair anchor of a demand response vehicle, the wheelchair strap to secure the wheelchair restraint to the wheelchair, further comprising a wheelchair strap sensor configured to provide a wheelchair strap sensor signal indicating whether the wheelchair strap is securely connected to a wheelchair via the wheelchair strap.

Abstract: There is a system for secure use of a wheelchair in demand response transportation systems comprising a wheelchair restraint comprising a central housing disposed between a vehicle strap and a wheelchair strap, the vehicle strap to secure the wheelchair restraint to the demand response vehicle, further comprising a vehicle strap sensor configured to provide a vehicle strap sensor electrical signal indicating whether the vehicle strap is securely affixed to a wheelchair anchor of a demand response vehicle, the wheelchair strap to secure the wheelchair restraint to the wheelchair, further comprising a wheelchair strap sensor configured to provide a wheelchair strap sensor signal indicating whether the wheelchair strap is securely connected to a wheelchair via the wheelchair strap.

Abstract: A luminaire described herein reduces energy consumption without limiting the light output and beam spreads. This configuration is useful for retail applications where a dimmable point source illumination is beneficial and minimal degradation due to damaging UV, IR, and heat may be important to product shelf life. The luminaire combines a light source, a thermal management system, a printed circuit board, and optics and shielding components in a single unit to accomplish these objectives. The substantially cylindrical lighting assembly includes a plurality of LEDs configured to emit light from a front end; a thermal management system for cooling the LEDs from a back end; a printed circuit board electrically coupled to the LEDs and the thermal management system; a refractor positioned adjacent the LEDs on the front end; and a shielding component positioned along the front end of the lighting assembly.

Abstract: The invention provides adhesive and sealant compositions prepared from urethane prepolymers. The urethane prepolymers are obtained by reacting the novel urethane diols, polyester polyols and polyether polyols with an excess of diisocyanate. The urethane diols are prepared by reacting excess low molecular weight diols and diisocyanates. The invention is particularly useful in end use applications such as panel lamination.

Abstract: An individual tetrahydrocannabinol isomer of interest is separated from a mixture containing two or more such isomers, by treating the mixture with an isocyanate or isothiocyanate of formula I: R—(CH2)n—N?C?X??(I) where R represents an aromatic ring optionally substituted with one or more electron withdrawing groups, n=0 or 1 and X is oxygen or sulphur; so as to produce a crystallizable THC carbamate of formula II: wherein X and R are as defined above, R? is a C3-C10 alkyl group and the dotted lines indicate optional unsaturation including aromatic, separating the compound of formula II from solution in isolation of other THC derivatives, and hydrolyzing the compound of formula II to form the individual tetrahydrocannabinol isomer of interest.

Abstract: Toner particles comprise resin, wax and optionally colorants, and the wax is substantially excluded from the interior core of the toner particles. Processes for preparing such toner particles comprise providing an aqueous dispersion of resin particles and optionally colorants, mixing the aqueous dispersion in presence of a coagulant, aggregating to form particles, coalescing to form fused particles, and removing the fused particles from the aqueous dispersion. Wax dispersions can be added either after mixing or during aggregation, so that wax is excluded from the core of the toner particles.

Abstract: An individual tetrahydrocannabinol isomer of interest is separated from a mixture containing two or more such isomers, by treating the mixture with an isocyanate or isothiocyanate of formula I: R—(CH2)n—N?C?X??(I) where R represents an aromatic ring optionally substituted with one or more electron withdrawing groups, n=0 or 1 and X is oxygen or sulphur; so as to produce a crystallizable THC carbamate of formula II: wherein X and R are as defined above, R? is a C3-C10 alkyl group and the dotted lines indicate optional unsaturation including aromatic, separating the compound of formula II from solution in isolation of other THC derivatives, and hydrolyzing the compound of formula II to form the individual tetrahydrocannabinol isomer of interest.