Patents by Inventor Louise D. McCullough

Louise D. McCullough has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Method of neuroprotection by pharmacological inhibition of AMP-activated protein kinase
    Patent number: 8293791
    Abstract: A method of neuroprotection which comprises administration of an AMPK inhibitor to a patient who is experiencing or has experienced a stroke, the compound being an AMPK inhibitor. Treatments with these agents significantly reduce the size of infarcts, and therefore minimize the loss of brain tissue and neurons. Thus, function can be preserved after stroke or ischemic injury in the brain. Similarly, neuronal loss can be minimized in degenerative diseases that cause neuronal compromise by perturbing energy utilization and availability in neurons.
    Type: Grant
    Filed: March 23, 2005
    Date of Patent: October 23, 2012
    Assignees: FASgen, LLC, Johns Hopkins University
    Inventors: Louise D. McCullough, Jill Sturdivant, Gabriele V. Ronnett
  • NOVEL METHOD OF NEUROPROTECTION BY PHARMACOLOGICAL INHIBITION OF AMP-ACTIVATED PROTEIN KINASE
    Publication number: 20090137665
    Abstract: A method of neuroprotection which comprises administration of an AMPK inhibitor to a patient who is experiencing or has experienced a stroke, the compound being an AMPK inhibitor. Treatments with these agents significantly reduce the size of infarcts, and therefore minimize the loss of brain tissue and neurons. Thus, function can be preserved after stroke or ischemic injury in the brain. Similarly, neuronal loss can be minimized in degenerative diseases that cause neuronal compromise by perturbing energy utilization and availability in neurons.
    Type: Application
    Filed: March 23, 2005
    Publication date: May 28, 2009
    Inventors: Louise D. McCullough, Jill Sturdivant, Gabriele V. Ronnett