Patents by Inventor Louise Matheson

Louise Matheson has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Method of identifying VDJ recombination products
    Patent number: 9797014
    Abstract: The invention relates to a method of identifying VDJ recombination products which comprises the use of sequence specific enrichment and specific restriction endonuclease enzymes or other DNA-shearing approaches to provide high resolution and high throughput interrogation of antigen receptor repertoires.
    Type: Grant
    Filed: March 1, 2013
    Date of Patent: October 24, 2017
    Assignee: The Babraham Institute
    Inventors: Andrew Wood, Daniel Bolland, Louise Matheson, Anne Corcoran
  • METHOD OF IDENTIFYING VDJ RECOMBINATION PRODUCTS
    Publication number: 20150031042
    Abstract: The invention relates to a method of identifying VDJ recombination products which comprises the use of sequence specific enrichment and specific restriction endonuclease enzymes or other DNA-shearing approaches to provide high resolution and high throughput interrogation of antigen receptor repertoires.
    Type: Application
    Filed: March 1, 2013
    Publication date: January 29, 2015
    Applicant: The Babraham Institute
    Inventors: Andrew Wood, Daniel Bolland, Louise Matheson, Anne Corcoran
  • H-Chain-only antibodies
    Publication number: 20100122358
    Abstract: The invention relates to mice having functionally silenced endogenous lambda (?) and kappa (?) L-chain loci, comprising antibody-producing cells in which the CH1 domain is functionally silenced, either via spontaneous processes in somatic antibody-producing cells or due to germline deletion of the CH1 domain. Mice of the invention are capable of producing H-chain-only antibody lacking a functional CH1 domain; transgenic human heavy-chain-only antibodies lacking a functional CH1 domain can be produced following insertion into the mouse of an artificial locus with human heavy chain V, D and J segments and a constant region, which is preferably a modified constant region with alterations in, around or upstream of a CH1 domain and/or removal of a CH1 domain.
    Type: Application
    Filed: June 8, 2009
    Publication date: May 13, 2010
    Applicant: Crescendo Biologics Limited
    Inventors: Marianne Brüggemann, Xiangang Zou, Louise Matheson, Michael Osborn