Patents by Inventor Louise Walsh

Louise Walsh has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Antibody variants
    Patent number: 8440190
    Abstract: This invention relates to an antibody which is modified version of a therapeutic antibody with affinity for a cell-surface antigen, the antibody having reduced affinity for the antigen compared with the therapeutic antibody as a result of a modification or modifications to the antibody molecule, wherein the antibody is capable of inducing immunological tolerance to the therapeutic antibody. The invention further relates to a method of inducing immunological tolerance to a therapeutic antibody, comprising administering to a patient an antibody which is a modified version of the therapeutic antibody and which has reduced affinity for the antigen as compared with the therapeutic antibody.
    Type: Grant
    Filed: July 14, 2005
    Date of Patent: May 14, 2013
    Assignee: Isis Innovation Limited
    Inventors: Herman Waldmann, Lisa K Gilliland, Masahide Tone, Mark R Frewin, Louise Walsh
  • Silicon compounds and their use
    Publication number: 20070110708
    Abstract: A compound of formula (I) or formula (II) wherein the variables are as defined in the claims.
    Type: Application
    Filed: June 18, 2004
    Publication date: May 17, 2007
    Inventors: David Miller, Parminder Ruprah, Graham Showell, Louise Walsh
  • Antibody variants
    Publication number: 20060018898
    Abstract: This invention relates to an antibody which is modified version of a therapeutic antibody with affinity for a cell-surface antigen, the antibody having reduced affinity for the antigen compared with the therapeutic antibody as a result of a modification or modifications to the antibody molecule, wherein the antibody is capable of inducing immunological tolerance to the therapeutic antibody. The invention further relates to a method of inducing immunological tolerance to a therapeutic antibody, comprising administering to a patient an antibody which is a modified version of the therapeutic antibody and which has reduced affinity for the antigen as compared with the therapeutic antibody.
    Type: Application
    Filed: July 14, 2005
    Publication date: January 26, 2006
    Inventors: Herman Waldmann, Lisa Gilliland, Masahide Tone, Mark Frewin, Louise Walsh
  • ANTIBODY VARIANTS
    Publication number: 20020048578
    Abstract: This invention relates to an antibody which is a modified version of a therapeutic antibody with affinity for a cell-surface antigen, said antibody having reduced affinity for the antigen compared with the therapeutic antibody as a result of a modification or modifications to the antibody molecule, wherein the antibody is capable of inducing immunological tolerance to the therapeutic antibody. The invention further relates to a method of inducing immunological tolerance to a therapeutic antibody comprising administering to a patient an antibody which is a modified version of the therapeutic antibody and which has reduced affinity for the antigen as compared with the therapeutic antibody.
    Type: Application
    Filed: August 19, 1998
    Publication date: April 25, 2002
    Inventors: HERMAN WALDMANN, LISA K GILLILAND, MASAHIDE TONE, MARK R FREWIN, LOUISE WALSH
  • CDR grafted humanised chimeric T-cell antibodies
    Patent number: 5502167
    Abstract: A humanised antibody is provided in which the amino acid sequence of the CDRs is derived from the sequence of CDRs of a monoclonal antibody having the specificity of binding to resting and activated T-cells, inhibiting T-cell proliferation and lysing T-cells from mice transgenic for human CD2 and in which sufficient of the amino acid sequence of each CDR has been retained to provide the same specificity for the humanised antibody.
    Type: Grant
    Filed: July 15, 1994
    Date of Patent: March 26, 1996
    Inventors: Herman Waldmann, Louise Walsh, James S. Crowe, Alan P. Lewis