Abstract: The disclosure relates to nucleic acids that contain modifications at the 5?-end, 3?-end or 5?-end and 3?-ends, and compounds that can be used to make the modified nucleic acids are disclosed. The modified nucleic acids have improved expression, lower immunogenicity and improved stability compared to unmodified nucleic acids.

Abstract: The disclosure relates to nucleic acids that contain modifications at the 5?-end, 3?-end or 5?-end and 3?-ends, and compounds that can be used to make the modified nucleic acids are disclosed. The modified nucleic acids have improved expression, lower immunogenicity and improved stability compared to unmodified nucleic acids.

Abstract: A securing pocket for managing the loose portion of a medical tube, such as a Nasogastric/Nasojejunal tube, while an implanted portion of the medical tube remains attached to the patient. The loose portion of the medical tube has a coiled section disposed within a receptacle formed between flexible front and rear panels. An integral flap overlaps the front panel to selectively close the receptacle and may be secured with a snap connector. Jam cleats are located along left and right edges adjacent a top edge of the receptacle. Each jam cleat forms a breach in the receptacle through which a tethered section of the loose medical tube extends. The jam cleats are configured to apply a progressive wedge force on the tethered section of the loose medical tube in response to tension along the tube. The jam cleat has flexible sides formed in a V-shape.

Abstract: The disclosed Hi-C protocol can identify genomic loci that are spatially co-located in vivo. These spatial co-locations may include, but are not limited to, intrachromosomal interactions and/or interchromosomal interactions. Hi-C techniques may be applied to many different scales of interest. For example, on a large scale, Hi-C techniques can be used to identify long-range interactions between distant genomic loci.

Abstract: A method and apparatus for rendering data representing the effect of glycaemic change mediating factors on glycaemia. The method comprises: recording a commencement time for a first glycaemic change mediating factor and an expected impact level for the first glycaemic change mediating factor, and plotting a first timeline from the recorded commencement time of the first glycaemic change mediating factor, representative of the estimated effect on glycaemia of the first glycaemic change mediating factor, based on the recorded expected impact level for the first glycaemic change mediating factor; wherein the rendering comprises: aligning the first plotted timeline to represent the estimated effect from a start point corresponding to a current time, and moving the first plotted timeline relative to the start point, as time progresses.

Abstract: The disclosed Hi-C protocol can identify genomic loci that are spatially co-located in vivo. These spatial co-locations may include, but are not limited to, intrachromosomal interactions and/or interchromosomal interactions. Hi-C techniques may be applied to many different scales of interest. For example, on a large scale, Hi-C techniques can be used to identify long-range interactions between distant genomic loci.

Abstract: The disclosure relates to nucleic acids that contain modifications at the 5?-end, 3?-end or 5?-end and 3?-ends, and compounds that can be used to make the modified nucleic acids are disclosed. The modified nucleic acids have improved expression, lower immunogenicity and improved stability compared to unmodified nucleic acids.

Abstract: This invention is in the field of medicinal chemistry and relates to compounds, and pharmaceutical compositions thereof that are useful as antibacterial agents. The compounds are useful as inhibitors of bacterial gyrase activity and of bacterial infections, and have the structure of Formula (I): as further described herein. The invention further provides pharmaceutical compositions comprising a compound of Formula (I) and methods of using the compounds and compositions to treat bacterial infections.

Abstract: The disclosed Hi-C protocol can identify genomic loci that are spatially co-located in vivo. These spatial co-locations may include, but are not limited to, intrachromosomal interactions and/or interchromosomal interactions. Hi-C techniques may be applied to many different scales of interest. For example, on a large scale, Hi-C techniques can be used to identify long-range interactions between distant genomic loci.

Abstract: Rapid methods that identify sepsis-causing bacteria or yeast aid the physician in critical therapeutic decision-making, thus decreasing patient mortality rates. The methods described herein employ plating microorganisms directly on to a MALDI-MS plate, adding concentrated formic acid, and identifying the microorganism by mass spectrometry. Optionally, an organic solvent may be combined with the formic acid, or added to the sample before or after the concentrated formic acid is added thereto. The methods enable direct extraction of proteins from microorganisms without the need for liquid protein extraction methods and yields positive identification results for gram-positive bacteria, gram-negative bacteria and yeast in minutes.

Abstract: The disclosed Hi-C protocol can identify genomic loci that are spatially co-located in vivo. These spatial co-locations may include, but are not limited to, intrachromosomal interactions and/or interchromosomal interactions. Hi-C techniques may be applied to many different scales of interest. For example, on a large scale, Hi-C techniques can be used to identify long-range interactions between distant genomic loci.

Abstract: The disclosed Hi-C protocol can identify genomic loci that are spatially co-located in vivo. These spatial co-locations may include, but are not limited to, intrachromosomal interactions and/or interchromosomal interactions. Hi-C techniques may be applied to many different scales of interest. For example, on a large scale, Hi-C techniques can be used to identify long-range interactions between distant genomic loci.

Abstract: The disclosed Hi-C protocol can identify genomic loci that are spatially co-located in vivo. These spatial co-locations may include, but are not limited to, intrachromosomal interactions and/or interchromosomal interactions. Hi-C techniques may be applied to many different scales of interest. For example, on a large scale, Hi-C techniques can be used to identify long-range interactions between distant genomic loci.

Abstract: The present invention is related to genomic nucleotide sequencing. In particular, the invention describes a paired end sequencing method that improves the yield of long-distance genomic read pairs by constructing long-insert clone libraries (i.e., for example, a fosIll library or a fosCN library) and converting the long-insert clone library using inverse polymerase chain reaction amplification or shearing and recircularization of shortened fragments into a library of co-ligated clone-insert ends. The resultant jumping libraries are compatible with massively parallel sequencing techniques. The compositions and methods disclosed herein contemplate sequencing complex genomes as well as detecting chromosomal structural rearrangements.

Abstract: The disclosed Hi-C protocol can identify genomic loci that are spatially co-located in vivo. These spatial co-locations may include, but are not limited to, intrachromosomal interactions and/or interchromosomal interactions. Hi-C techniques may be applied to many different scales of interest. For example, on a large scale, Hi-C techniques can be used to identify long-range interactions between distant genomic loci.

Abstract: A dialog is configured to display first and second pages of attribute fields to prompt an input of attribute values for use in accomplishing the task. Each page is separately displayable in the dialog. According to exemplary embodiments, a dynamically alterable summary of the attribute fields and values is included on a portion of the first page of the dialog. The attribute fields and values included in the summary are arranged into groups. A first group includes the attribute fields and values displayable on the first page of the dialog, and a second group includes the attribute fields and values displayable on the second page of the dialog. A first software link is provided between the second group and the second page of the dialog to provide automated access to the second page via the second group.

Abstract: When used as suggested, this invention uses Anhydrous MgSO4.7H2O as the primary substance, in liquid or solid forms, to control the appearance of shiny and oily skin, and hair; and also manages body moisture under normal situations and environmental conditions. Formulas are predetermined unit measurements to achieve or maintain the desired results. I. Liquid forms are achieved by mixing the primary substance with water or other creams or liquids creating mild/gentle, medium/regular, and super/maximum strengths. II. Solid forms can be mixed liquid or dry, then ground or compressed into a fine, compressed, or compact face or body powder. III. Both forms can be added or combined with fragrance, skin creams, lotions, and cosmetic products. IV. Either product can be reapplied as often as desired or needed.

Abstract: A particulate trap has a housing and a plurality of filters disposed within the housing. The particulate trap also has a plurality of dividers fluidly isolating one or more of the plurality of filters into filter divisions. The particulate trap has at least one inlet and at least one outlet individually associated with each filter division, and a valve assembly configured to selectively block a flow of exhaust air through each of the inlets.

Abstract: A particulate trap has a plurality of filters and an air distributor. The air distributor has an inner tube and an outer tube. Each of the inner and outer tubes have a plurality of openings to allow exhaust flow to the plurality of filters. One of the inner and outer tubes is rotatable to selectively block exhaust flow to at least one of the plurality of filters at a given time.