Patents by Inventor Lowell D. Hatfield

Lowell D. Hatfield has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Chiral intermediates for the preparation of carbacephems
    Patent number: 5700933
    Abstract: The present invention is directed to azetidinone compounds of the following formula: ##STR1## which are useful as intermediates to carbacephalosporins: ##STR2## These carbacephalosporins are useful as antibacterials.
    Type: Grant
    Filed: May 18, 1995
    Date of Patent: December 23, 1997
    Assignee: Eli Lilly and Company
    Inventors: Jack W. Fisher, Lowell D. Hatfield, Richard C. Hoying, James E. Ray
  • Intermediates for the preparation of carbacephems
    Patent number: 5644051
    Abstract: This invention is directed to carbacephems and methods for their preparation: ##STR1## In the foregoing formulae, R.sup.3 represents phenyl, C.sub.1 -C.sub.4 alkylphenyl, halophenyl, C.sub.1 -C.sub.4 alkoxyphenyl, naphthyl, thienyl, furyl, benzothienyl, or benzofuryl.
    Type: Grant
    Filed: May 18, 1995
    Date of Patent: July 1, 1997
    Assignee: Eli Lilly and Company
    Inventors: Jack W. Fisher, Lowell D. Hatfield, Richard C. Hoying, James E. Ray
  • Methods and compounds for the preparation of carbacephems
    Patent number: 5521307
    Abstract: A chiral process for preparing compounds of the formula: ##STR1## from a compound of the formula: ##STR2## in which the compound formula (IV) is reacted with trimethylsilyl iodide to remove the chiral auxiliary at the 7-position and the carboxy protecting group. The process allows for the retention of the amino and carboxy protecting groups throughout the preparation of Compound IV. Also disclosed are novel intermediates.
    Type: Grant
    Filed: February 18, 1992
    Date of Patent: May 28, 1996
    Assignee: Eli Lilly and Company
    Inventors: Jack W. Fisher, Lowell D. Hatfield, Richard C. Hoying, James E. Ray
  • Oxidation process
    Patent number: 4502988
    Abstract: Penicillin and cephalosporin sulfides and sulfoxides are readily converted to sulfones in the presence of ruthenium tetroxide.
    Type: Grant
    Filed: August 8, 1983
    Date of Patent: March 5, 1985
    Assignee: Eli Lilly and Company
    Inventor: Lowell D. Hatfield
  • Thiazolinoazetidinones and process therefor
    Patent number: 4271305
    Abstract: Novel halogenating compounds, derived from triaryl phosphites and chlorine or bromine are employed to convert 7-acylamino-3-hydroxy-3-cephem compounds to 7-acylamino-3-halo-3-cephems and the corresponding C-7 imino halide cephem derivatives. The product 3-halo-3-cephems are antibiotic compounds or intermediates thereto.
    Type: Grant
    Filed: December 14, 1979
    Date of Patent: June 2, 1981
    Assignee: Eli Lilly and Company
    Inventors: Lowell D. Hatfield, Larry C. Blaszczak, Jack W. Fisher
  • Halogenating reagents
    Patent number: 4230644
    Abstract: Novel halogenating agents are derived from triaryl phosphites and chlorine or bromine. They are useful in converting 7-acylamino-3-hydroxy-3-cephem compounds to 7-acylamino-3-halo-3-cephems and the corresponding C-7 imino halide cephem derivatives.
    Type: Grant
    Filed: February 1, 1979
    Date of Patent: October 28, 1980
    Assignee: Eli Lilly and Company
    Inventors: Lowell D. Hatfield, Larry C. Blaszczak, Jack W. Fisher
  • Process for halogenation of .beta.-lactam compounds
    Patent number: 4226986
    Abstract: Novel halogenating compounds, derived from triaryl phosphites and chlorine or bromine are employed to convert 7-acylamino-3-hydroxy-3-cephem compounds to 7-acylamino-3-halo-3-cephems and the corresponding C-7 imino halide cephem derivatives. The product 3-halo-3-cephems are antibiotic compounds or intermediates thereto.
    Type: Grant
    Filed: February 1, 1979
    Date of Patent: October 7, 1980
    Assignee: Eli Lilly and Company
    Inventors: Lowell D. Hatfield, Larry C. Blaszczak, Jack W. Fisher
  • Process for preparation of penicillin and cephalosporin imino halides
    Patent number: 4211702
    Abstract: Penicillin and cephalosporin imino halides are prepared by reacting of 6-acylaminopenicillins or 7-acylamino cephalosporins with a novel chlorinating compound derived from a triaryl phosphite and chlorine or bromine. The imino halide products are intermediates in the preparation of antibiotic compounds.
    Type: Grant
    Filed: February 1, 1979
    Date of Patent: July 8, 1980
    Assignee: Eli Lilly and Company
    Inventors: Lowell D. Hatfield, Larry C. Blaszczak, Jack W. Fisher
  • Azetidinone mercury sulfides and process therefor
    Patent number: 4175076
    Abstract: Novel azetidinone mercury sulfides are prepared by the reaction of penicillin derived thiazolineazetidinones with a mercuric halide in the presence of an alcohol or glycol. They are useful intermediates in the preparation of cephalosporin compounds.
    Type: Grant
    Filed: November 21, 1977
    Date of Patent: November 20, 1979
    Assignee: Eli Lilly and Company
    Inventor: Lowell D. Hatfield
  • Cephalosporin displacement reaction
    Patent number: 4144391
    Abstract: The present invention is directed to a process for the displacement of the acetoxy group of a cephalosporanic acid by a sulfur nucleophile, in an organic solvent and under essentially anhydrous conditions.
    Type: Grant
    Filed: December 27, 1977
    Date of Patent: March 13, 1979
    Assignee: Eli Lilly and Company
    Inventor: Lowell D. Hatfield
  • De-esterification process for cephalosporins
    Patent number: 4091214
    Abstract: p-Nitrobenzyl esters of cephalosporins are reductively cleaved with zinc and .alpha.-hydroxycarboxylic acids, e.g., the p-nitrobenzyl ester of the cephalosporin antibiotic, cephalexin, is reacted in an inert solvent with zinc and mandelic acid to provide the antibiotic, cephalexin, as the free acid in yields greater than 85 percent.
    Type: Grant
    Filed: February 25, 1977
    Date of Patent: May 23, 1978
    Assignee: Eli Lilly and Company
    Inventor: Lowell D. Hatfield
  • Reduction process for cephalosporin sulfoxides
    Patent number: 4044002
    Abstract: Cephalosporin sulfoxides are reduced to the corresponding cephalosporin with acyl bromides, e.g., acetyl bromide, in the presence of a bromine scavenger, e.g., an olefin, acetylene, phenol, phenol ether, or an organophosphite. For example, p-nitrobenzyl 7-phenoxyacetamido-3-methyl-3-cephem-4-carboxylate sulfoxide is reduced with acetyl bromide in the presence of amylene to p-nitrobenzyl 7-phenoxyacetamido-3-methyl-3-cephem-4-carboxylate.
    Type: Grant
    Filed: June 9, 1976
    Date of Patent: August 23, 1977
    Assignee: Eli Lilly and Company
    Inventor: Lowell D. Hatfield
  • Deacetoxycephalosporins via penicillin sulfoxide rearrangement
    Patent number: 3953440
    Abstract: Penicillin sulfoxides, notably the sulfoxides of penicillin V and penicillin G, are heated with amine salts of dichloromethane phosphonate in 1,1,2-trichloroethane to provide superior yields of deacetoxycephalosporins. The process is especially valuable in providing greater yields of the intermediate in the synthesis of the commercial antibiotic, cephalexin.
    Type: Grant
    Filed: December 13, 1974
    Date of Patent: April 27, 1976
    Assignee: Eli Lilly and Company
    Inventor: Lowell D. Hatfield