Patents by Inventor Lowell J. Tyner
Lowell J. Tyner has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 8741287Abstract: The present disclosure relates to glycosylated and deglycosylated human PlGF-1, methods of using the glycosylated and deglycosylated human PlGF-1, antibodies that bind to human PlGF-1, methods of using the antibodies and human PlGF-1 immunoassays and kits.Type: GrantFiled: June 16, 2009Date of Patent: June 3, 2014Assignee: Abbott LaboratoriesInventors: Susan E. Brophy, Lianli Chi, Saul A Datwyler, David J. Hawksworth, Don M. Laird, Sharmila Manoj, Mary S. Pinkus, Dominick L. Pucci, Carol S. Ramsay, David C. Sogin, Bailin Tu, Zhiguang Yu, Robert N. Ziemann, Lowell J. Tyner
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Patent number: 8349325Abstract: An isolated antibody that specifically binds to sFlt-1 or a fragment thereof having (i) a variable heavy domain region comprising the amino acid sequence of SEQ ID NO: 2, (ii) a variable light domain region comprising the amino acid sequence of SEQ ID NO: 4, or (iii) both (i) and (ii), a pharmaceutical composition and a kit comprising such an antibody, a method of making such an antibody, a method of determining the presence, amount or concentration of sFlt-1 or a fragment thereof in a test sample, a method of treating a patient in therapeutic or prophylactic need of an antagonist of sFlt-1, an isolated nucleic acid comprising a nucleotide sequence encoding the amino acid sequence of (i) SEQ ID NO: 2, (ii) SEQ ID NO: 4, or (iii) both (i) and (ii), optionally as part of a vector, and a host cell comprising and expressing such a nucleic acid.Type: GrantFiled: December 21, 2009Date of Patent: January 8, 2013Assignee: Abbott LaboratoriesInventors: Susan E. Brophy, Saul A. Datwyler, David J. Hawksworth, Don C. Laird, Sharmila Manoj, Dominick L. Pucci, Bryan C. Tieman, Joan Tyner, Lowell J. Tyner, legal representative, Zhiguang Yu
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Publication number: 20120142022Abstract: The present invention relates to glycosylated mammalian NGAL, and methods of using said glycosylated mammalian NGAL.Type: ApplicationFiled: January 19, 2012Publication date: June 7, 2012Applicant: ABBOTT LABORATORIESInventors: Bailin Tu, Joan D. Tyner, Lowell J. Tyner
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Publication number: 20120076803Abstract: The subject invention relates to antibodies to troponin I as well as methods of use thereof. In particular, such antibodies may be used to detect Troponin I in a patient and may also be used in the diagnosis of, for example, a myocardial infarction or acute coronary syndrome.Type: ApplicationFiled: February 23, 2010Publication date: March 29, 2012Applicant: ABBOTT LABORATORIESInventors: Susan E. Brophy, Bailin Tu, Joan D. Tyner, Lowell J. Tyner, Dagang Huang, Robert N. Ziemann
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Patent number: 8030026Abstract: The subject invention relates to antibodies to troponin I as well as methods of use thereof. In particular, such antibodies may be used to detect Troponin I in a patient and may also be used in the diagnosis of, for example, a myocardial infarction or acute coronary syndrome.Type: GrantFiled: February 24, 2009Date of Patent: October 4, 2011Assignee: Abbott LaboratoriesInventors: Susan E. Brophy, Bailin Tu, Joan D. Tyner, Lowell J. Tyner, legal representative, Dagang Huang, Robert N. Ziemann
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Patent number: 7998480Abstract: The present invention relates to antibodies that immunospecifically bind to human brain natriuretic peptide or a human brain natriuretic peptide fragment with a high binding affinity, methods for producing and selecting said antibodies, immunoassays for human brain natriuretic peptide or a human brain natriuretic peptide fragment that employ said antibodies and therapeutic compositions containing said antibodies.Type: GrantFiled: August 11, 2008Date of Patent: August 16, 2011Assignee: Abbott LaboratoriesInventors: Susan E. Brophy, Joan D. Tyner, Lowell J. Tyner, legal representative, Bailin X. Tu, Mary S. Pinkus, Jessie W. Shih, Bryan C. Tieman
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Publication number: 20100266575Abstract: An isolated antibody that specifically binds to sFlt-1 or a fragment thereof having (i) a variable heavy domain region comprising the amino acid sequence of SEQ ID NO: 2, (ii) a variable light domain region comprising the amino acid sequence of SEQ ID NO: 4, or (iii) both (i) and (ii), a pharmaceutical composition and a kit comprising such an antibody, a method of making such an antibody, a method of determining the presence, amount or concentration of sFlt-1 or a fragment thereof in a test sample, a method of treating a patient in therapeutic or prophylactic need of an antagonist of sFlt-1, an isolated nucleic acid comprising a nucleotide sequence encoding the amino acid sequence of (i) SEQ ID NO: 2, (ii) SEQ ID NO: 4, or (iii) both (i) and (ii), optionally as part of a vector, and a host cell comprising and expressing such a nucleic acid.Type: ApplicationFiled: December 21, 2009Publication date: October 21, 2010Applicant: ABBOTT LABORATORIESInventors: Susan E. Brophy, Saul A. Datwyler, David J. Hawksworth, Don C. Laird, Sharmila Manoj, Dominick L. Pucci, Bryan C. Tieman, Joan Tyner, Lowell J. Tyner, Zhiguang Yu
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Publication number: 20100216720Abstract: The subject invention relates to antibodies to troponin I as well as methods of use thereof. In particular, such antibodies may be used to detect Troponin I in a patient and may also be used in the diagnosis of, for example, a myocardial infarction or acute coronary syndrome.Type: ApplicationFiled: February 24, 2009Publication date: August 26, 2010Applicant: ABBOTT LABORATORIESInventors: Susan E. Brophy, Bailin Tu, Joan D. Tyner, Dagang Huang, Robert N. Ziemann, Lowell J. Tyner
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Publication number: 20100015637Abstract: The present disclosure relates to glycosylated and deglycosylated human PlGF-1, methods of using the glycosylated and deglycosylated human PlGF-1, antibodies that bind to human PlGF-1, methods of using the antibodies and human PlGF-1 immunoassays and kits.Type: ApplicationFiled: June 16, 2009Publication date: January 21, 2010Applicant: ABBOTT LABORATORIESInventors: Susan E. Brophy, Lianli Chi, Saul A. Datwyler, David J. Hawksworth, Don M. Laird, Sharmila Manoj, Mary S. Pinkus, Dominick L. Pucci, Carol S. Ramsay, David C. Sogin, Bailin Tu, Joan D. Tyner, Lowell J Tyner, Zhiguang Yu, Robert N. Ziemann
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Publication number: 20090269777Abstract: The present invention relates to NGAL immunoassays and kits, and to methods of using glycosylated mammalian NGAL and antibodies that bind to mammalian NGAL in immunoassays and kits. Among other things, the methods and kits can be employed to determine the amount of human NGAL monomer in a test sample, as well as to determine the proportion of human NGAL monomer to human NGAL dimer contained in a test sample.Type: ApplicationFiled: April 16, 2008Publication date: October 29, 2009Applicant: Abbott LaboratoriesInventors: Larry G. Birkenmeyer, Suresh M. Desai, Frank C. Grenier, David J. Hawksworth, Edward T. Olejniczak, Qiaoqiao Ruan, Robert W. Siegel, Sergey Y. Tetin, Bryan C. Tieman, Bailin Tu, Joan D. Tyner, Lowell J. Tyner, Ryan F. Workman, Robert N. Ziemann
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Publication number: 20090203037Abstract: The present disclosure is directed to reagents and methods of using the reagents to detect epitopes of Trypanosoma cruzi.Type: ApplicationFiled: December 23, 2008Publication date: August 13, 2009Applicant: Abbott LaboratoriesInventors: Susan E. Brophy, David J. Hawksworth, Dinesh O. Shah, Robert W. Siegel, Bryan C. Tieman, Bailin Tu, Joan D. Tyner, Lowell J. Tyner, Robert N. Ziemann
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Publication number: 20090148866Abstract: The present disclosure relates to isolated antibodies that can be used in an assay to determine the concentration levels of myeloperoxidase (MPO) in a test sample. Additionally, the present disclosure also relates to the use of improved test sample handling methods in assays in order to preserve the original MPO levels in the test sample.Type: ApplicationFiled: May 16, 2008Publication date: June 11, 2009Applicant: Abbott LaboratoriesInventors: Saul A. Datwyler, David J. Hawksworth, Stephen C. Hsu, Matthew S. Matias, David P. Pacenti, Mary S. Pinkus, Jessie W. Shih, Bryan C. Tieman, Joan D. Tyner, Robert N. Ziemann, Lowell J. Tyner
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Publication number: 20090124022Abstract: The present invention relates to antibodies specific for glycosylated mammalian NGAL, and to methods of making and using such antibodies.Type: ApplicationFiled: April 16, 2008Publication date: May 14, 2009Applicant: Abbott LaboratoriesInventors: Larry G. Birkenmeyer, Suresh M. Desai, David J. Hawksworth, Edward T. Olejniczak, Qiaoqiao Ruan, Robert W. Siegel, Sergey Y. Tetin, Bryan C. Tieman, Bailin Tu, Joan D. Tyner, Robert N. Ziemann, Lowell J. Tyner
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Publication number: 20090123946Abstract: The present invention relates to NGAL immunoassays and kits, and to methods of using glycosylated mammalian NGAL and antibodies that bind to mammalian NGAL in immunoassays and kits. Among other things, the methods and kits can be employed to determine the amount of human NGAL monomer in a test sample, as well as to determine the proportion of human NGAL monomer to human NGAL dimer contained in a test sample.Type: ApplicationFiled: December 5, 2008Publication date: May 14, 2009Applicant: ABBOTT LABORATORIESInventors: Larry G. Birkenmeyer, Suresh M. Desai, Frank C. Grenier, David J. Hawksworth, Edward T. Olejniczak, Qiaoqiao Ruan, Robert W. Siegel, Sergey Y. Tetin, Bryan C. Tieman, Bailin Tu, Joan D. Tyner, Ryan F. Workman, Robert N. Ziemann, Lowell J. Tyner
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Publication number: 20090123473Abstract: The present invention relates to antibodies that immunospecifically bind to human brain natriuretic peptide or a human brain natriuretic peptide fragment with a high binding affinity, methods for producing and selecting said antibodies, immunoassays for human brain natriuretic peptide or a human brain natriuretic peptide fragment that employ said antibodies and therapeutic compositions containing said antibodies.Type: ApplicationFiled: August 11, 2008Publication date: May 14, 2009Applicant: ABBOTT LABORATORIESInventors: Susan E. Brophy, Joan D. Tyner, Bailin X. Tu, Mary S. Pinkus, Jessie W. Shih, Bryan C. Tieman, Lowell J. Tyner
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Patent number: RE45763Abstract: The subject invention relates to antibodies to troponin I as well as methods of use thereof. In particular, such antibodies may be used to detect Troponin I in a patient and may also be used in the diagnosis of, for example, a myocardial infarction or acute coronary syndrome.Type: GrantFiled: September 24, 2013Date of Patent: October 20, 2015Assignee: Abbott LaboratoriesInventors: Susan E. Brophy, Bailin Tu, Dagang Huang, Lowell J. Tyner, Robert N. Ziemann