Abstract: The present disclosure relates to systems, methods, and devices that may be used to incentivize inhaler use.

Abstract: Residence structures, systems, and related methods are generally provided. Certain embodiments comprise administering (e.g., orally) a residence structure to a subject (e.g., a patient) such that the residence structure is retained at a location internal to the subject for a particular amount of time (e.g., at least about 24 hours) before being released. The residence structure may be, in some cases, a gastric residence structure. In some embodiments, the structures and systems described herein comprise one or more materials configured for high levels of active substances (e.g., a therapeutic agent) loading, high active substance and/or structure stability in acidic environments, mechanical flexibility and strength in an internal orifice (e.g., gastric cavity), easy passage through the GI tract until delivery to at a desired internal orifice (e.g., gastric cavity), and/or rapid dissolution/degradation in a physiological environment (e.g., intestinal environment) and/or in response to a chemical stimulant (e.

Abstract: An embodiment of a system for treating sleep apnea includes a collar, pump, motor, sensor, memory, and controller, which is configured to store, in the memory, information related to sleep-apnea events or sleep-apnea treatment, experienced by the subject. For example, the controller can obtain, and store in the memory, information related to sleep-apnea events, and the controller, or another computing system, can correlate this information with the subject's lifestyle choices, and can recommend lifestyle changes to improve the subject's sleep apnea. Furthermore, the controller can obtain and store, in the memory, information related to usage and settings of the sleep-apnea system, and the controller, or another computing system, can correlate this information with the subject's wellbeing, and can recommend changes in the usage or the settings of the sleep-apnea system that can improve the subject's wellbeing.

Abstract: Emulsion-based and micromolded (“MM”) or three dimensional printed (“3DP”) polymeric formulations for single injection of antigen, preferably releasing at two or more time periods, have been developed. Formulations are preferably formed of biocompatible, biodegradable polymers. Discrete regions encapsulating antigen, alone or in combination with other antigens, adjuvants, stabilizers, and release modifiers, are present in the formulations. Antigen is preferably present in excipient at the time of administration, or on the surface of the formulation, for immediate release, and incorporated within the formulation for release at ten to 45 days after initial release of antigen, optionally at ten to 90 day intervals for release of antigen in one or more additional time periods. Antigen may be stabilized through the use of stabilizing agents such as trehalose glass. In a preferred embodiment for immunization against polio, antigen is released at the time of administration, and two, four and six months thereafter.

Abstract: The present disclosure relates to methods and devices that may be used to separate components from one or more samples.

Abstract: Portage storage containers including controlled evaporative cooling systems are described herein. In some embodiments, a portable container including an integral controlled evaporative cooling system includes: a storage region, an evaporative region adjacent to the storage region, a desiccant region adjacent to the outside of the container, and an insulation region positioned between the evaporative region and the desiccant region. A vapor conduit with an attached vapor control unit has a first end within the evaporative region and a second end within the desiccant region. In some embodiments, the controlled evaporative cooling systems are positioned in a radial configuration within the portable container.

Abstract: According to various embodiments, an array of elements forms an artificially-structured material. The artificially-structured material can also include an array of tuning mechanisms included as part of the array of elements that are configured to change material properties of the artificially-structured material on a per-element basis. The tuning mechanisms can change the material properties of the artificially-structured material by changing operational properties of the elements in the array of elements on a per-element basis based on one or a combination of stimuli detected by sensors included in the array of tuning mechanisms, programmable circuit modules included as part of the array of tuning mechanisms, data stored at individual data stores included as part of the array of tuning mechanisms, and communications transmitted through interconnects included as part of the array of elements.

Abstract: An embodiment of a system for treating sleep apnea includes a collar, pump, motor, sensor, memory, and controller, which is configured to store, in the memory, information related to sleep-apnea events or sleep-apnea treatment, experienced by the subject. For example, the controller can obtain, and store in the memory, information related to sleep-apnea events, and the controller, or another computing system, can correlate this information with the subject's lifestyle choices, and can recommend lifestyle changes to improve the subject's sleep apnea. Furthermore, the controller can obtain and store, in the memory, information related to usage and settings of the sleep-apnea system, and the controller, or another computing system, can correlate this information with the subject's wellbeing, and can recommend changes in the usage or the settings of the sleep-apnea system that can improve the subject's wellbeing.

Abstract: Devices, compositions, and methods are described which provide a tubular nanostructure or a composite tubular nanostructure targeted to a lipid bilayer membrane. The tubular nanostructure includes a hydrophobic surface region flanked by two hydrophilic surface regions. The tubular nanostructure is configured to interact with a lipid bilayer membrane and form a pore in the lipid bilayer membrane. The tubular nanostructure may be targeted by including at least one ligand configured to bind to one or more cognates on the lipid bilayer membrane of a target cell.

Abstract: Methods, computer program products, and systems are described that include measuring at least one effect of a combined bioactive agent and artificial sensory experience on an individual and/or modifying at least one of the bioactive agent or the artificial sensory experience at least partially based on the at least one effect.

Abstract: Residence devices as well as their related methods of manufacture and use are generally provided. In some embodiments, a residence device includes a plurality of self-assembling structures that assemble in vivo to form an aggregate structure. Each structure of the plurality of structures includes a first side and a first attachment point that attaches to a second attachment point on another structure of the plurality of structures. The aggregate structure may be sized and shaped to maintain an in vivo position relative to an internal orifice of a subject. The attachment between the first and second attachment points may degrade after a period of time.

Abstract: Configuration technologies for apportioning resources and communicating indications of potential or actual incentives based on one or more measurements or other objective indications that therapeutic components have been administered to an individual, other attributes of the therapeutic components or the individual, or other such determinants. Techniques for apportioning resources cost-effectively (between providers and other parties, e.g.) and for facilitating or handling implementations thereof or output therefrom.

Abstract: A nuclear fission reactor, flow control assembly, methods therefor and a flow control assembly system. The flow control assembly is coupled to a nuclear fission module capable of producing a traveling burn wave at a location relative to the nuclear fission module. The flow control assembly controls flow of a fluid in response to the location relative to the nuclear fission module. The flow control assembly comprises a flow regulator subassembly configured to be operated according to an operating parameter associated with the nuclear fission module. In addition, the flow regulator subassembly is reconfigurable according to a predetermined input to the flow regulator subassembly. Moreover, the flow control assembly comprises a carriage subassembly coupled to the flow regulator subassembly for adjusting the flow regulator subassembly to vary fluid flow into the nuclear fission module.

Abstract: Systems, methods, computer-readable storage mediums including computer-readable instructions and/or circuitry for control of transmission to a target device with communicating with one or more sensors in an ad-hoc sensor network may implement operations including, but not limited to: receiving electrical power via at least one structurally integrated electrically conductive element; and powering one or more sensing operations of one or more sensors via the electrical power.

Abstract: The present disclosure relates to systems, methods, and devices that may be used to incentivize inhaler use.

Abstract: The present disclosure provides systems and methods associated with acoustic transmitters, receivers, and antennas. Specifically, the present disclosure provides a transducer system for transmitting and receiving acoustic energy according to a determined acoustic emission/reception pattern. In various embodiments, an acoustic transducer system may include an array of sub-wavelength transducer elements each configured with an electromagnetic resonance at one of a plurality of electromagnetic frequencies. Each sub-wavelength transducer element may generate an acoustic emission in response to the electromagnetic resonance. A beam-forming controller may cause electromagnetic energy to be transmitted at select electromagnetic frequencies to cause a select subset of the sub-wavelength transducer elements to generate acoustic emissions according to a selectable acoustic transmission pattern. A common port may facilitate electromagnetic communication with each of the sub-wavelength transducer elements.

Abstract: An apparatus includes a base having a first surface and an array of pillars. Each pillar of the array of pillars includes (i) a first end attached to the first surface of the base; (ii) a second end having an electric charge retention portion; (iii) a physical separation from adjacent pillars of the array of pillars; and (iv) an electrical conductor configured to electrically connect the electric charge retention portion with a bus structure. The bus structure is configured to addressably connect with the electrical conductor of each respective pillar of the array of pillars.

Abstract: Embodiments disclosed herein relate to a garment system including at least one sensor and at least one actuator that operates responsive to sensing feedback from the at least one sensor to cause a flexible compression garment to selectively constrict or selectively dilate, thereby compressing or relieving compression against at least one body part of a subject. Such selective constriction or dilation can improve muscle functioning or joint functioning during use of motion-conducive equipment, such as an exercise bike or rowing machine.

Abstract: In one embodiment, a particular state of a body is sensed. In response to the sensing, at least one action is taken to modulate a projected adverse interaction between the body or a portion thereof and at least one object in the environment of the body. An apparatus, methods and computer program product, and system are described that enable a first subset of actuatable cushioning elements for a first time period, enable a second subset of actuatable cushioning elements for a second time period, determine an event, and actuate, based on a time the event is determined, at least one of the first and the second subsets of actuatable cushioning elements to provide cushioning support for an object. Other example embodiments are also provided relating to actuatable cushioning elements.

Abstract: Methods, computer program products, and systems are described that include measuring at least one effect of a combined bioactive agent and artificial sensory experience on an individual and/or modifying at least one of the bioactive agent or the artificial sensory experience at least partially based on the at least one effect.