Abstract: A personal skin cleansing wipe comprising a flexible substantially dry matrix formed from synthetic, woven, non-woven or knitted fibers impregnated with a substantially anhydrous antimicrobial, antiseptic, antifungal solution in an amount wherein the matrix retains its substantially dry characteristics and the treatment solution includes an amount of PVP-iodine as active in solution in glycol and or glycerin. The treatment solution, in addition to an effective amount of PVP-iodine as active, contains surfactants, preferably Tego® Betaine CK D, and optionally a compatible fragrance and/or moisturizer. The wipe is activated with water just prior to use.

Abstract: A personal skin cleansing wipe comprising a flexible substantially dry matrix formed from fabrics made of synthetic, woven, non-woven, or knitted fibers impregnated with a substantially anhydrous antimicrobial, antiseptic, antifungal solution in an amount wherein the matrix retains its substantially dry characteristics and the treatment solution includes an amount of PVP-iodine in solution in a glycol, glycerine or mixture thereof. The treatment solution in addition to an effective amount of PVP-iodine as active, contains surfactants (nonionic and/or cationic and/or amphoteric) and optionally a compatible fragrance. The wipe is activated with water just prior to use.

Abstract: This invention relates to a process for preparing bioabsorbable oxidized cellulose comprising combining cellulose material, with nitrogen dioxide and a nonaqueous solvent chosen from the class of perfluorinated tertiary amines. This invention also relates to a method of oxidizing cellulose material comprising introducing a solvent into the vessel, circulating the solvent through the cellulose material, adding nitrogen dioxide to said vessel containing the solvent and cellulose in the required amounts, circulating the solution for 7 to 24 hours while controlling the reaction temperature, and isolating the oxidized material. Preferably, isolation of the oxidized product is followed by first washing the oxidized cellulose material with cold water, then washing the oxidized cellulose material with an aqueous alcohol solution several times, then washing the material with 100% alcohol several times, and finally drying the oxidized material.

Abstract: This invention relates to a process for preparing bioabsorbable oxidized cellulose comprising combining cellulose material, with nitrogen dioxide and a nonaqueous solvent chosen from the class of perfluorinated tertiary amines. This invention also relates to a method of oxidizing cellulose material comprising introducing a solvent into the vessel, circulating the solvent through the cellulose material, adding nitrogen dioxide to said vessel containing the solvent and cellulose in the required amounts, circulating the solution for 7 to 24 hours while controlling the reaction temperature, and isolating the oxidized material. Preferably, isolation of the oxidized product is followed by first washing the oxidized cellulose material with cold water, then washing the oxidized cellulose material with an aqueous alcohol solution several times, then washing the material with 100% alcohol several times, and finally drying the oxidized material.

Abstract: A personal skin cleansing wipe comprising a flexible substantially dry matrix formed from synthetic, woven, non-woven, or knitted fibers impregnated with a substantially anhydrous antimicrobial, antiseptic, antifungal solution in an amount wherein the matrix retains its substantially dry characteristics and the treatment solution includes an amount of PVP-iodine in solution in glycerol and/or glycerine. The treatment solution in addition to an effective amount of PVP iodine as active, contains surfactants and optionally a compatible fragrance. The wipe is activated with water just prior to use.

Abstract: The present invention is directed to a process of concomitant scouring and oxidizing cellulose in a solution of nitrogen oxide and perfluorinated hydrocarbon and subsequent washings of the oxidized fabric with isopropyl alcohol, where the perfluorinated hydrocarbon solvent preferably has a boiling point in the range of between about 30° C. and about 100° C., the nitrogen oxide concentration in the solution is in the range between about 2% and about 12% by weight, the reactants are maintained at a temperature between about 25° C. to about 40° C. for a total time duration of at least about 7 hours, the oxidized cellulose is subsequently washed with Fluorinert solvent, cold water, 50:50 isopropyl alcohol:water and 100% isopropyl alcohol, followed by drying with warm nitrogen gas. The resulting oxidized fabric exhibits a residual oil content substantially equivalent to fabric that has been scoured in hot aqueous and detergent but does not suffer the shrinkage associated with aqueous scouring.

Abstract: Bioabsorbable medical devices are prepared by oxidizing derivatives of cellulose, including methyl cellulose, carboxymethylcellulose, and cellulose acetate. The resulting material is formed into films, sponges and, in the case of oxidized methyl cellulose, gels, due to its unique property of being water soluble. The resulting devices are particularly useful in limiting surgical adhesions, and for hemostasis. Other uses include wound dressings and as a replacement for more expensive bioabsorbable gels such as hyaluronic acid.

Abstract: An improved adhesion-preventative physical barrier, wound dressing and drug delivery system comprising an oxidized cellulose film made up of multiple layers of a cellulose fabric or like material and a cellulose film. A method for forming an improved oxidized cellulose film and for using the same to prevent the formation of postsurgical adhesions and/or to dress a wound and/or to deliver one or more drugs.

Abstract: An electrical connector for a cardiac device is disclosed. The connector has a wire and an electrode at the distal end of the wire. The wire is attached to a patch, and the patch is coated with an adhesive film for adhering the patch to tissue. The preferred connector is a bipolar temporary cardiac pacing wire. The use of an adhesive film eliminates or reduces the need for suturing the patch to tissue, thus avoiding or significantly reducing tissue trauma associated with suturing.

Abstract: A substantially flexible, dry matrix with antimicrobial properties is made from a matrix comprising natural or synthetic, woven, non-woven or knitted fibers, said matrix having been uniformly coated with an amount of a non-aqueous treatment solution sufficient to allow said matrix to retain its substantially dry characteristics. In a preferred embodiment, said non-aqueous treatment solution has between about 70% and 99% of at least one glycol compound, between about 1% and 15% of a PVP-iodine and optionally between about 0 and 15% of a non-ionic surfactant.Also, skin is treated to prevent disease, such as the disinfecting of teats on dairy cows during milking, by wiping the skin with the article.

Abstract: A hemostatic paste composition comprising a hemostatic effective amount of thrombin in a polyethylene glycol base which is preferably prepared by admixing an aqueous solution of thrombin and polyethylene glycol and freeze-drying the mixture to remove substantially all of the water to yield a viscous water soluble paste of fine particles of thrombin uniformly dispersed throughout the polyethylene glycol base, and methods of its use to provide hemostasis to a hemorrhaging site of a mammal.

Abstract: A process for oxidizing cellulose involves reacting the cellulose with a solution of nitrogen dioxide in a perfluorocarbon solvent. In preferred embodiments, the solvent has a boiling point in the range between about 30.degree. C. and 100.degree. C., the nitrogen dioxide concentration in the solution is in the range between about 2% and 12% by weight, and the reactants are maintained at a temperature between about 25.degree. C. and 60.degree. C. during a reaction time fo at least about 7 hours.

Abstract: Oxidized cellulose material is neutralized, by contacting an acidic oxidized cellulose material with a water and alcohol solution of a basic salt of a weak organic acid, e.g. sodium acetate, to elevate the pH of the cellulosic material to between 5 and 8. The resulting neutralized product is storage stable and has therapeutic applications, including hemostasis and adhesion prevention. Furthermore, the neutralized product may be impregnated with acid-sensitive hemostatic agents, such as thrombin, to enhance its hemostatic properties, or with acid-sensitive adhesion-preventive agents, such as t-PA, to enhace its adhesion-prevention properties.

Abstract: A hemostatic collagen paste composition comprising a mixture, by weight of the total composition, of 2 to 30% of crosslinked collagen powder of 10 to 100 mesh particle size and 30 to 98% of water or an aqueous saline solution and hemostatic paste compositions that also comprise a hemostatic enhancing amount of thrombin, as well as methods of making and using such hemostatic collagen paste compositions.

Abstract: A process is disclosed for delivery thrombin in dry powdered form from an aerosol container by first lyophilizing an aqueous solution of thrombin and a thrombin-compatible synthetic polymer e.g. polyvinyl pyrrolidone, placing the lyophilized cake in a pressure bottle by crimping on a valve stem and top, filling liquified chlorofluoroalkane-containing aerosol propellant into the bottle, and actuating the valve to dispense in dry-finely divided powdered form a mixture of thrombin and polyvinyl pyrrolidone, which powdered thrombin is for use in controlling bleeding during surgery.

Abstract: Hemostatic adhesive bandages are disclosed wherein a very thin coating of a high molecular weight polyethylene oxide is applied to the surface of the perforated plastic film wound release cover of an adhesive bandage, in a manner compatible with commonly used high speed production techniques and equipment, which stop the bleeding faster when applied to minor cuts.

Abstract: The present invention relates to a process for preparing certain halogenated aromatic polyesters by an inverse interfacial polymerization technique. More specifically, the present invention offers a method for substantially reducing the amount of low molecular weight fraction which accompanies the formation of these polyesters when prepared by standard interfacial polymerization techniques by (1) inverting the order of addition of one phase to the other, i.e. by adding the aqueous phase to the organic phase, (2) controlling the rate of addition of the aqueous phase to the organic phase and (3) adding the catalyst to the organic phase prior to the addition of the aqueous phase thereto.

Abstract: Self-extinguishing, non-dripping, melt processible copolyesters of reduced toxicity are provided from a mixture of diols comprising from about 25 to 60 mole percent of phenolphthalein and from about 75 to 40 mole percent of ethylene glycol and a dicarboxylic acid comprising isophthalic acid and/or terephthalic acid.