Abstract: An antibody-drug conjugate containing a side chain of a functional small molecule for enhancement of targeted treatment of cancers and refractory diseases is provided. The preparation of such conjugate, pharmaceutical compositions, and methods in treatment of refractory diseases are also provided.

Abstract: A display substrate and a display device are provided, the display substrate includes a base substrate and a circuit structure layer disposed on the base substrate, the circuit structure layer includes a pixel circuit, a light emitting drive circuit, a scan drive circuit, a control drive circuit and a buffer drive circuit; the pixel circuit includes a node reset transistor, a writing transistor, a reset signal line connected to a control electrode of the node reset transistor, a scan signal line connected to a control electrode of the writing transistor, and a control signal line.

Abstract: A display substrate and a display apparatus. The display substrate includes multiple circuit units, a circuit unit at least includes a pixel drive circuit, the pixel drive circuit at least includes a second transistor, a third transistor, a fourth transistor and a ninth transistor, a gate electrode of the third transistor is connected to a second electrode of the ninth transistor, a first electrode of the third transistor is connected to a second electrode of the fourth transistor, a second electrode of the third transistor is connected to a second electrode of the second transistor, and a first electrode of the second transistor is connected to a first electrode of the ninth transistor; the second transistor and the ninth transistor are configured such that a moment when the ninth transistor is turned off is earlier than a moment when the second transistor is turned off in the data writing stage.

Abstract: A display substrate includes a base substrate, a scan line and a driving module arranged on the base substrate, at least two transistors in the driving circuit have a first gate electrode and a second gate electrode; at least a portion of the second gate electrode is located between the first gate electrode and the base substrate; bottom gate via holes of at least two transistors of the driving circuit are arranged along a first direction; the second gate electrode is electrically connected to a connection portion through the bottom gate via hole, and the connection portion is electrically connected to the first gate electrode; or, the second gate electrode is electrically connected to the first gate electrode through the bottom gate via hole; the first direction intersects with a second direction, and the scan line includes at least a portion extending along the second direction.

Abstract: Disclosed are an array substrate, a display panel, and a display device. The array substrate includes: a base substrate; gate line groups; data lines; transistors; first pixel electrodes and second pixel electrodes; where an orthographic projection, on the base substrate, of at least one of a plurality of common wires is between orthographic projections, on the base substrate, of adjacent gate line groups; and an orthographic projection, on the base substrate, of at least one of a plurality of connection lines is in an orthographic projection, on the base substrate, of a gap between adjacent pixel electrode rows; and an insulation layer and the common wires having first via holes, where orthographic projections, on the base substrate, of the first via holes are in orthographic projections, on the base substrate, of regions between two pixel edge extension lines, extending in a second direction, of pixel electrodes.

Abstract: A method includes accessing train data for a hub and accessing one or more user preferences of a plurality of user preferences. The method further includes determining, based on the train data, a driving distance for each of a plurality of candidate units to be loaded on an outbound train. The method further includes determining, based on the determined driving distances for the candidate units to be loaded on the outbound train, a track order. The method further includes determining, based on the determined track order, a plurality of units from the plurality of candidate units to load on the outbound train. The method further includes generating a load plan using the determined plurality of units to load on the outbound train.

Abstract: A touch-control display panel is provided with a display region, a peripheral region and a lead-out region, wherein the peripheral region is located outside the display region; and the lead-out region is arranged outside the peripheral region in a column direction, and the lead-out region has a bonding portion for connecting to a flexible circuit board. The touch-control display panel includes a touch-control layer and a drive chip. The drive chip is provided with a touch-control pin group and gating circuits, wherein the touch-control pin group includes first touch-control pins, which include functional pins and dummy pins; and the touch-control layer is connected to the functional pins by means of touch-control leads, one functional pin being connected to one touch-control lead.

Abstract: A display substrate is provided. The display substrate has a display region and a peripheral region at least partially surrounding the display region, and includes: a base substrate, a first barrier dam, a first power signal line, a crack detection circuit, and a crack detection circuit, an orthographic projection of at least part of a boundary of the first power signal line away from the display region on the base substrate is located inside an orthographic projection of the first barrier dam on the base substrate; and an orthographic projection of the crack detection circuit on the base substrate at least partially overlaps with an orthographic projection of the first barrier dam on the base substrate.

Abstract: A heat dissipator, a heat dissipation apparatus, and an electronic device are disclosed. The heat dissipator includes a base body, and a liquid distribution cavity, a liquid collection cavity, and a heat exchange cavity. The base body is provided with a liquid inlet end and a liquid outlet end. The liquid distribution cavity is located in the base body, and a first end of the liquid distribution cavity is communicated with the liquid inlet end. The liquid collection cavity is located in the base body, and a first end of the liquid collection cavity is communicated with the liquid outlet end. The heat exchange cavity is located in the base body and is provided with a liquid inlet and a liquid outlet. The liquid inlet is communicated with the liquid distribution cavity, and the liquid outlet is communicated with the liquid collection cavity.

Abstract: A display substrate is provided. The display substrate includes a base substrate, and a shift register unit and a first clock signal line that are on the base substrate, the first clock signal line extends along a first direction on the base substrate and is configured to provide a first clock signal to the shift register unit, the shift register unit includes an input circuit, an output circuit, a first control circuit and an output control circuit, and the input circuit includes an input transistor, an active layer of the input transistor is in a strip shape extending along a second direction, and the second direction is different from the first direction.

Abstract: A display substrate and a display apparatus are provided. The display substrate comprises a base, a power signal line pattern, and a plurality of subpixels that each comprise an anode pattern, wherein the power signal line pattern comprises a first power line portion and a second power line portion; and at least a part of the first power line portion extends in a first direction; the plurality of subpixels comprise first and second subpixels, an overlap between the anode pattern of the first subpixel and the power signal line pattern is larger in area than an overlap between the anode pattern of the second subpixel and the power signal line pattern, and an overlap between the anode pattern of the first subpixel and the first power line portion is larger in area than an overlap between the anode pattern of the first subpixel and the second power line portion.

Abstract: A display substrate and an electronic device are provided. The display substrate includes a base substrate, including a display region and a peripheral region on at least one side of the display region; and a shift register unit and a first clock signal line in the peripheral region of the base substrate, wherein the first clock signal line extends along a first direction on the base substrate, and is connected to a first clock signal terminal to be configured to provide a first clock signal to the shift register unit; the shift register unit includes an input circuit, an output circuit, a first control circuit, and an output control circuit; the output control circuit includes an output control transistor and a first capacitor, and the output circuit includes an output transistor and a second capacitor.

Abstract: A formulation of conjugates of tubulysin analogs with a cell-binding molecule having a structure represented by Formula (I), wherein T, L, m, n, , R1, R2, R3, R4, R5, R6, R7, R8, R9, R10, R11, R12, and R13 are as defined herein, can be used for targeted treatment of cancer, autoimmune disease, and infectious disease.

Abstract: A formulation of conjugates of tubulysin analogs with a cell-binding molecule having a structure represented by Formula (I), wherein T, L, m, n, ----, R1, R2, R3, R4, R1, R6, R7, R1, R9, R10, R11, R12, and R13 are as defined herein, can be used for targeted treatment of cancer, autoimmune disease, and infectious disease.

Abstract: A touch-control display panel is provided with a display region, a peripheral region and a lead-out region, wherein the peripheral region is located outside the display region; and the lead-out region is arranged outside the peripheral region in a column direction, and the lead-out region has a bonding portion for connecting to a flexible circuit board. The touch-control display panel includes a touch-control layer and a drive chip. The drive chip is provided with a touch-control pin group and gating circuits, wherein the touch-control pin group includes first touch-control pins, which include functional pins and dummy pins; and the touch-control layer is connected to the functional pins by means of touch-control leads, one functional pin being connected to one touch-control lead.

Abstract: Provided is a display substrate. The display substrate includes: a display region and a bonding region on a side of the display region, wherein the display region includes a plurality of pixel columns; and a wiring structure, disposed between the display region and the bonding region and including a plurality of traces, wherein one of the plurality of traces corresponds to one of the plurality of pixel columns, the plurality of traces are electrically connected to the plurality of pixel columns to supply an electric signal to pixels, and each of the plurality of traces includes a plurality of sub-traces, wherein at least one of line lengths and line widths of sub-traces corresponding to at least a part of the plurality of traces are different, such that total resistances of the at least the part of the plurality of traces are basically equal.

Abstract: The present disclosure provides a display panel (PNL), a motherboard structure, and a display device, and belongs to the field of display technologies. The display panel (PNL) has a display area (AA) and a peripheral area (BB) surrounding the display area (AA); and the peripheral area (BB) has an inner cut line (ICUT) surrounding the display area (AA). The motherboard structure includes a plurality of display panels (PNL), and the motherboard structure has a main cut line (MCUT) between the display panels (PNL). An outer cut line (OCUT) is disposed in at least a partial area between the main cut line (MCUT) and the inner cut line (ICUT) of the display panel (PNL); an end of the outer cut line (OCUT) is intersected with the inner cut line (ICUT); and a second crack dam (DAM2) is disposed between the outer cut line (OCUT) and the inner cut line (ICUT).

Abstract: Disclosed are a display substrate and a display apparatus, wherein the display substrate may include a base substrate including a display region and a non-display region, and a drive circuit layer disposed on the base substrate, the drive circuit layer includes a pixel drive circuit located in the display region and a gate drive circuit located in the non-display region; a boundary of the display region includes an arc-shaped boundary, a non-display region located on an outside of the arc-shaped boundary is referred to as a rounded corner region, and the rounded corner region includes a plurality of first regions and at least one second region; the gate drive circuit is configured to provide a drive signal to the pixel drive circuit, and is partially located within a first region, and the second region is located between adjacent first regions.

Abstract: A display substrate and a display apparatus. The display substrate includes an electrostatic discharge protection circuit, a power supply line, and at least one auxiliary electrode. The electrostatic discharge protection circuit includes multiple electrostatic discharge protection units, at least one of which extends along a first inclined direction, there is a first preset included angle between the first inclined direction and a first direction, the first direction is an extension direction of a scan signal line in the display region, the first preset included angle is greater than 0° and less than 90°; the first trace region includes the power supply line and at least one auxiliary electrode, an orthographic projection of the at least one auxiliary electrode on a display substrate plane is overlapped with that of the power supply line on the display substrate plane, the at least one auxiliary electrode is connected with the power supply line.