Abstract: The present invention provides novel compounds having the general formula: wherein R1 to R6, X, Y, A1 and A2 are as described herein, compositions including the compounds and methods of using the compounds.

Abstract: The present invention relates to compounds of formula (I), wherein R1, R2 and R3 are as described herein, and their prodrugs or pharmaceutically acceptable salt, enantiomer or diastereomer thereof, and compositions including the compounds and methods of using the compounds.

Abstract: The present invention relates to compounds of formula (I), wherein R1, R2 and R3 are as described herein, and their prodrugs or pharmaceutically acceptable salt, enantiomer or diastereomer thereof, and compositions including the compounds and methods of using the compounds.

Abstract: The invention provides novel compounds having the general formula: wherein R1, R2, R3, R4, R5, R6, W1, W2, W3, A and X are as described herein, compositions including the compounds and methods of using the compounds for the treatment and prophylaxis of respiratory syncytial virus infection.

Abstract: Described are LiDAR systems comprising a transmission optical system and a collection optical system utilizing a common lens or pieces derived from the same lens to reduce or eliminate image mismatch between the transmission optical system and the collection optical system.

Abstract: Described are LiDAR systems including an apparatus configured to translate one or more spherical lenses, an array of light sources, an array of photodetectors, or any combination thereof of a collection optical system in the Z direction (optical axis) to move the image plane of the collection optical system and match the image size between a transmission optical system and the collection optical system.

Abstract: Data can be accessed from a plurality of disparate data sources from at least one database. A plurality of test models can be automatically built by a model building engine. Each test model can have predetermined predictive variables. A final set of predictive variables can be determined by a variable selector from the predetermined predictive variables in the plurality of test models by comparing the predictive power of the predictive variables across the plurality of test models. A master dataset can be generated from the disparate data sources. A master model can be built from the master dataset. The master model can combine the final set of predictive variables from the plurality of disparate data sources. The master model can characterize a quantitative estimate of the probability that an entity will display a defined behavior. Related apparatus, systems, techniques, and articles are also described.

Abstract: The present invention is directed to compositions and methods for treating hepatitis B virus infection. In particular, the present invention is directed to a combination therapy comprising administration of an HBV capsid assembly inhibitor and an interferon for use in the treatment of hepatitis B virus infections.

Abstract: The present invention relates to compounds of formula (I), wherein R1, R2 and R3 are as described herein, and their prodrugs or pharmaceutically acceptable salt, enantiomer or diastereomer thereof, and compositions including the compounds and methods of using the compounds.

Abstract: Acoustically responsive particles and methods are provided for their use. Methods are provided for making and using tunable, monodisperse acoustically responsive particles and negative contrast acoustic particles, wherein the particles can contain a functional group available for covalent modification.

Abstract: The invention provides novel compounds having the general formula: wherein R1, R2, R3, R4, R5, R6, W1, W2, W3, A and X are as described herein, compositions including the compounds and methods of using the compounds.

Abstract: The present invention relates to compounds of formula (I), wherein R1, R2 and R3 are as described herein, and their prodrugs or pharmaceutically acceptable salt, enantiomer or diastereomer thereof, and compositions including the compounds and methods of using the compounds.

Abstract: In some implementations, a camera module includes an image sensor, a lens assembly comprising a first portion configured to receive light along a first optical axis and a second portion that includes a plurality of lens elements that share a second optical axis that is different from the first optical axis, a reflective element arranged to alter a path of light entering the camera in a direction along the first optical axis to a direction along the second optical axis, at least two independent actuators configured to tilt the reflective element about a pivot point, and one or more resilient elements configured to bias a position of the reflective element.

Abstract: Data can be accessed from a plurality of disparate data sources from at least one database. A plurality of test models can be automatically built by a model building engine. Each test model can have predetermined predictive variables. A final set of predictive variables can be determined by a variable selector from the predetermined predictive variables in the plurality of test models by comparing the predictive power of the predictive variables across the plurality of test models. A master dataset can be generated from the disparate data sources. A master model can be built from the master dataset. The master model can combine the final set of predictive variables from the plurality of disparate data sources. The master model can characterize a quantitative estimate of the probability that an entity will display a defined behavior. Related apparatus, systems, techniques, and articles are also described.

Abstract: The present invention is directed to compositions and methods for treating hepatitis B virus infection. In particular, the present invention is directed to a combination therapy comprising administration of a TLR7 agonist and an HBV capsid assembly inhibitor for use in the treatment of chronic hepatitis B patient.

Abstract: A blue glass infrared cutoff filter is disclosed that contains an aspheric epoxy replicated on a first surface of the infrared cutoff filter. The aspheric epoxy and blue glass infrared cutoff filter may be a component of a camera device that includes a lens barrel with one or more lenses disposed therein. The camera device may include a sensor for detecting light received by the camera device. The sensor may be connected to circuitry that dispatches the detection data generated by the sensor to a processor of a device into which the camera device has been incorporated.

Abstract: The present invention relates to a recombinant HBV cccDNA comprising HBV genome or the fragment or variant thereof and a site-hybrid insert, a method to generate said recombinant HBV cccDNA, a method for establishment of an in vitro or in vivo cccDNA based model for persistently hepatitis B virus replication by using the recombinant HBV cccDNA of the present invention, and a method for anti-HBV drug evaluation.

Abstract: Acoustically responsive particles and methods are provided for their use. Methods are provided for making and using tunable, monodisperse acoustically responsive particles and negative contrast acoustic particles, wherein the particles can contain a functional group available for covalent modification.

Abstract: The invention provides novel compounds having the general formula: wherein R1, R2, R3 and Q are as described herein, compositions including the compounds and methods of using the compounds.

Abstract: Data can be accessed from a plurality of disparate data sources from at least one database. A plurality of test models can be automatically built by a model building engine. Each test model can have predetermined predictive variables. A final set of predictive variables can be determined by a variable selector from the predetermined predictive variables in the plurality of test models by comparing the predictive power of the predictive variables across the plurality of test models. A master dataset can be generated from the disparate data sources. A master model can be built from the master dataset. The master model can combine the final set of predictive variables from the plurality of disparate data sources. The master model can characterize a quantitative estimate of the probability that an entity will display a defined behavior. Related apparatus, systems, techniques, and articles are also described.