Abstract: The invention provides immune effector cells (for example, T cells, NK cells) that express a chimeric antigen receptor (CAR), and compositions and methods thereof.

Abstract: A rechargeable energy storage system includes a housing including a tray and a sidewall structure. A plurality of beam assemblies extend in parallel across the housing, the plurality of beam assemblies each include a bottom cap having a base plate and pair of parallel ribs extending from the base plate. A coolant passage plate is sandwiched between a pair of undulating plates with a first end disposed between the pair of parallel ribs of the bottom cap. The coolant passage plate is connected to a coolant source. A plurality of battery cells are disposed in the housing and in contact with the undulating plates of adjacent beam assemblies.

Abstract: A beam for supporting a plurality of prismatic batteries in battery enclosure of an electric vehicle includes a base, having a lower elongate horizontal flange, and an upper elongate horizontal flange, narrower than the lower elongate horizontal flange, spaced above the lower elongate horizontal flange by a vertical web. A web member can be disposed on the upper elongate horizontal flange of the base, and includes first and second elongate exterior vertical wall members. At least two elongate inserts disposed between the vertical exterior wall members, and configured to at least in part form at least one longitudinally extending channel between them. The elongate inserts can be made of metal and the longitudinally extending channel provides a pathway for cooling fluid. A cap can engage the upper edges of the vertical wall members and enclose the metal inserts in the space between the first and second vertical wall members.

Abstract: The invention provides compositions and methods for treating diseases associated with expression of CD19, e.g., by administering a recombinant T cell comprising the CD19 CAR as described herein, in combination with one or more B-cell inhibitors, e.g., inhibitors of one or more of CD10, CD20, CD22, CD34, CD123, FLT-3, ROR1, CD79b, CD179b, or CD79a. The disclosure additionally features novel antigen binding domains and CAR molecules directed to CD20 and CD22, and uses, e.g., as monotherapies or in combination therapies. The invention also provides kits and compositions described herein.

Abstract: Disclosed are a method and apparatus for training an acoustic network model, and an electronic device, a readable storage medium, a computer program product and a program, wherein same belong to the technical field of data processing. The method comprises: acquiring a training sample for training of an acoustic network model, wherein the training sample includes one or more speech files (S101); performing peak detection on speech included in the speech file by using a BLSTM network, so as to divide letters included in the speech file on the basis of a detected peak, thereby forming segmented speech (S102); performing semantic prediction on the segmented speech on the basis of a preset CTC segmentation network to obtain a text prediction result (S103); and after the prediction result meets a preset performance requirement, stopping the training of the acoustic network model so as to perform text prediction on input speech by using the acoustic network model (S104).

Abstract: A multifunctional unified structure thermal plate and system for supporting a plurality of battery cells included as part of a high voltage battery pack. The plate may include a bottom plate and a plurality of crossbeams configured for supporting the battery cells, with the bottom plate and the crossbeams together being from as a monolithic, one-piece structure.

Abstract: The present disclosure relates to a field programmable gate array (FPGA)-based multi-channel dynamic light scattering (DLS) autocorrelation system and method. The system includes a DLS generation apparatus, a photon correlator, and a host computer, where the photon correlator includes an FPGA and a universal serial bus (USB) communication module; the DLS generation apparatus is connected to the FPGA; the FPGA is configured to count and perform correlation calculation on photon pulses generated by the DLS generation apparatus; the USB communication module is connected to the host computer; the FPGA includes a dual counter module and a correlation calculation module; the dual counter module is connected to the DLS generation apparatus and the correlation calculation module; the correlation calculation module is connected to the USB communication module; the dual counter module includes a plurality of dual counters; and the correlation calculation module includes a plurality of correlators.

Abstract: A ribbon speaker includes a housing, first and second magnet assemblies, a ribbon diaphragm, a coil, and a flexible substrate. The first and second magnet assemblies is arranged in the housing. The same poles of the first magnet assembly and the second magnet assembly are arranged opposite to each other. The diaphragm is positioned between these magnet assemblies. The coil, placed on this diaphragm, includes two first connection portions. The flexible substrate includes a body, two connection portions, and two soldering portions. The body's first part is inside the housing, while the second part arranged outside. The second connections on the body's first part electrically connected to the coil's first connections. The externally positioned soldering portions facilitate easier assembly, significantly reducing soldering complexity. The soldering portions are respectively and electrically connected to the second connection portions.

Abstract: A battery casing includes a first portion including a first planar portion and a bottom portion and a second portion having a second planar portion, a first side portion, and a second side portion, the first portion and the second portion configured to be welded together at (i) a first butt joint extending along the first side portion to join the first side portion to the first planar portion and to the bottom portion at the first side portion, (ii) a second butt joint extending along the second planar portion to join the second planar portion to the bottom portion at the second planar portion, and (iii) a third butt joint extending along the second side portion to join the second side portion to the first planar portion and to the bottom portion at the second side portion.

Abstract: The present disclosure provides BCMA binding molecules that specifically bind to human BCMA, conjugates comprising the BCMA binding molecules, and pharmaceutical compositions comprising the BCMA binding molecules and the conjugates. The disclosure further provides methods of using the BCMA binding molecules to treat cancers that express cell surface BCMA. The disclosure yet further provides recombinant host cells engineered to express the BCMA binding molecules and methods of producing the BCMA binding molecules by culturing the host cells under conditions in which the BCMA binding molecules are expressed.

Abstract: Techniques for implementing and/or operating a well system including a rotatable casing hanger and a rotatable running tool. The rotatable casing hanger includes a hanger body, which is to be secured to a casing string; a hanger sleeve secured circumferentially around the hanger body, in which the hanger sleeve is to be landed on another wellhead component; and a hanger bearing assembly disposed axially between the hanger body and the hanger sleeve. The rotatable running tool includes a tool body that defines a tool bore, in which the tool body is to be selectively secured to the hanger body; a tool sleeve secured circumferentially around the tool body to facilitate maintaining centralization of the tool body and, thus, the rotatable casing hanger; and a tool bearing assembly disposed between the tool body and the tool sleeve.

Abstract: A method for manufacturing an enclosure includes designing a two dimensional (2D) blank corresponding to a three dimensional (3D) enclosure body; laying out N of the 2D blanks on a metal sheet, where N is an integer greater than one; separating the N 2D blanks from the metal sheet; at least one of bending, folding and/or flanging the N 2D blanks into the 3D enclosure body; and joining a plurality of sides of the 3D enclosure body.

Abstract: An enclosure for a prismatic battery cell include first side surfaces, second side surfaces connected between the first side surfaces, a top surface connected between the first side surfaces and the second side surfaces, and a bottom surface connected between the first side surfaces and the second side surfaces. The first side surfaces, the second side surfaces, the top surface and the bottom surface are configured to receive a battery cell stack. The second side surfaces, the top surface and the bottom surface expand/contract to allow guided expansion/contraction of the enclosure in a first direction while limiting expansion in second and third directions transverse to the first direction.

Abstract: The present disclosure describes a multi-function, integrated Super Beam assembly structure with integrated structural, cooling, and transverse elastic compliance functions; and Thermal Management Propagation (TMP) protection. The Super Beam assembly includes a pair of parallel face plates, coolant channel cover plates, and coolant channels that are defined by the face plate and the one or more coolant channel cover plates. The structural design of the cooling channels, and the corresponding air gaps formed in-between them, allows a transverse elastic compliance of the Super Beam assembly to be tuned to different amounts of elasticity. Top, bottom and/or end structural channels may be included. A pair of TMP suppression channels may be attached to the Super Beam assembly structure with an adhesive “thermal fuse” that preferentially melts and causes the pair of TMP suppression channels to detach from the Super Beam assembly during overheating in a TMP event.

Abstract: A battery pack includes a first header having a first conduit and a second header having a second conduit. The battery pack also includes an energy storage system having energy storage cells arranged between the first header and the second header. A coolant plate assembly is arranged between the first header and the second header and abuts the plurality of energy storage cells. The coolant plate assembly includes a coolant channel having a first end fluidically connected to the first conduit, a second end fluidically connected to the second conduit, and an intermediate portion defining a flow path. The coolant plate assembly also includes a first planar section having a first surface facing the energy storage cells and a second surface having protrusions extending into the coolant channel.

Abstract: A device processing method and system, and a computer device and a readable storage medium. The method includes: upon acquiring configuration recommendation information for a device in a target space, which information is obtained by means of performing analysis on the basis of historical device operation data, pushing and displaying the device configuration recommendation information; in response to a selection operation for at least one device configuration item, the terminal device displaying device control information corresponding to a selected target device configuration item; and in response to a configuration operation for the selected target device configuration item, performing configuration processing on a corresponding device on the basis of the target device configuration item, wherein the device configuration item is generated according to the historical device operation data.