Patents by Inventor Lu Shan

Lu Shan has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • ANTI-HER2 ANTIBODIES AND METHODS OF USE THEREOF
    Publication number: 20260109781
    Abstract: In one aspect, antibodies that bind to subdomain II of human HER2 are provided. In another aspect, antibodies comprising a light chain polypeptide that pairs with both a heavy chain polypeptide for binding to subdomain II of human HER2 and a heavy chain polypeptide for binding to subdomain IV of human HER2 are provided. In a further aspect, antibodies that bind to both subdomain II and subdomain IV of human HER2 comprising a common light chain polypeptide are provided. Methods of treating a cancer or treating brain metastasis of a cancer using these antibodies are also provided.
    Type: Application
    Filed: October 8, 2025
    Publication date: April 23, 2026
    Inventors: Abira BANDYOPADHYAY, Allisa Jayne CLEMENS, Do Jin KIM, Michelle E. PIZZO, Lu SHAN, Richard THÉOLIS, Jr., Raymond Ka Hang TONG
  • TRANSFERRIN RECEPTOR ANTIGEN-BINDING DOMAINS AND USES THEREFOR
    Publication number: 20250270339
    Abstract: The present disclosure is generally directed to antigen-binding domains that specifically bind to human transferrin receptor (TfR) and their use in transport across the blood brain barrier (BBB).
    Type: Application
    Filed: January 28, 2025
    Publication date: August 28, 2025
    Inventors: Eric BROWN, Hamid SALIMI, Angie Grace YEE, Margaret L. TANG, Wei-Hsien HO, Tarangsri NIVITCHANYONG, Rajkumar GANESAN, Lu SHAN, Thunga BIENLY, Raymond Ka-Hang TONG, Alexander Hyun-min YANG
  • CD98HC ANTIGEN-BINDING DOMAINS AND USES THEREFOR
    Publication number: 20250270341
    Abstract: The present disclosure is generally directed to antigen-binding domains that specifically bind to human CD98 heavy chain (CD98hc) and their use in transport across the blood brain barrier (BBB).
    Type: Application
    Filed: January 28, 2025
    Publication date: August 28, 2025
    Inventors: Eric BROWN, Alexander Gregory GULEVICH, Hamid SALIMI, Angie Grace YEE, Margaret L. TANG, Tarangsri NIVITCHANYONG, Rajkumar GANESAN, Sarah A. JAHN, Lu SHAN, Thunga BIENLY, Raymond Ka-Hang TONG, Alexander Hyun-min YANG
  • ANTI-HER2 ANTIBODIES AND METHODS OF USE THEREOF
    Publication number: 20250136713
    Abstract: In one aspect, antibodies that bind to subdomain II of human HER2 are provided. In another aspect, antibodies comprising a light chain polypeptide that pairs with both a heavy chain polypeptide for binding to subdomain II of human HER2 and a heavy chain polypeptide for binding to subdomain IV of human HER2 are provided. In a further aspect, antibodies that bind to both subdomain II and subdomain IV of human HER2 comprising a common light chain polypeptide are provided. Methods of treating a cancer or treating brain metastasis of a cancer using these antibodies are also provided.
    Type: Application
    Filed: August 25, 2022
    Publication date: May 1, 2025
    Inventors: Abira BANDYOPADHYAY, Allisa Jayne CLEMENS, Do Jin KIM, Michelle E. PIZZO, Lu SHAN, Richard THÉOLIS, Jr., Raymond Ka Hang TONG
  • ENGINEERED ANTI-HER2 BISPECIFIC PROTEINS
    Publication number: 20240392035
    Abstract: In one aspect, bispecific proteins having the ability to specifically bind to both subdomain II of human HER2 and subdomain IV of human HER2 are provided. In another aspect, methods of treating a cancer or treating brain metastasis of a cancer using a bispecific protein that specifically binds to subdomain II and subdomain IV of human HER2 are provided.
    Type: Application
    Filed: August 25, 2022
    Publication date: November 28, 2024
    Inventors: Abira BANDYOPADHYAY, Allisa Jayne CLEMENS, Do Jin KIM, Michelle E. PIZZO, Lu SHAN, Richard THÉOLIS, Jr., Raymond Ka Hang TONG
  • OLIGONUCLEOTIDE CONJUGATES TARGETED TO THE TRANSFERRIN RECEPTOR
    Publication number: 20240299575
    Abstract: Provided herein are conjugates comprising proteins that bind to a transferrin receptor and oligonucleotides that are capable of modulating the expression of a target gene or sequence, as well as methods of use thereof.
    Type: Application
    Filed: July 1, 2022
    Publication date: September 12, 2024
    Inventors: Scarlett Barker, Mark S. Dennis, Sarah L. Devos, Anthony A. Estrada, Mihalis S. Kariolis, Cathal S. Mahon, Lizanne G. Nilewski, Joshua I. Park, Lu Shan, Mai B. Thayer, Raymond Ka Hang Tong, Hai L. Tran, Robert C. Wells, Joy Yu Zuchero
  • MODIFIED FCRN BINDING FRAGMENTS WITH IMPROVED HALF-LIFE
    Publication number: 20240239898
    Abstract: The present disclosure relates to modified FcRn binding fragments with improved half-life, specifically fusion proteins and polypeptides comprising said modified FcRn binding fragments, and methods of manufacturing said fusion proteins and their use in methods of treatment.
    Type: Application
    Filed: May 9, 2022
    Publication date: July 18, 2024
    Inventors: Vaheh Yuni OGANESYAN, Lu SHAN
  • ENZYME TREATMENT OF FOODSTUFFS FOR CELIAC SPRUE
    Publication number: 20170119860
    Abstract: Administering an effective dose of glutenase to a Celiac or dermatitis herpetiformis patient reduces levels of toxic gluten oligopeptides, thereby attenuating or eliminating the damaging effects of gluten.
    Type: Application
    Filed: January 11, 2017
    Publication date: May 4, 2017
    Inventors: Felix Hausch, Gary Gray, Lu Shan, Chaitan Khosla
  • Enzyme treatment of foodstuffs for celiac sprue
    Patent number: 8962545
    Abstract: Administering an effective dose of glutenase to a Celiac or dermatitis herpetiformis patient reduces levels of toxic gluten oligopeptides, thereby attenuating or eliminating the damaging effects of gluten.
    Type: Grant
    Filed: March 21, 2011
    Date of Patent: February 24, 2015
    Assignee: The Board of Trustees of the Leland Stanford Junior University
    Inventors: Felix Hausch, Gary Gray, Lu Shan, Chaitan Khosla
  • Enzyme treatment of foodstuffs for celiac sprue
    Patent number: 8796201
    Abstract: Administering an effective dose of glutenase to a Celiac or dermatitis herpetiformis patient reduces levels of toxic gluten oligopeptides, thereby attenuating or eliminating the damaging effects of gluten.
    Type: Grant
    Filed: November 4, 2011
    Date of Patent: August 5, 2014
    Assignee: The Board of Trustees of the Leland Stanford Junior University
    Inventors: Lu Shan, Michael Bethune, Chaitan Khosla, Jonathan Gass, Gail G. Pyle, Gary M. Gray, Indu Isaacs, Gregg Strohmeier
  • Diagnostic method for celiac sprue
    Patent number: 8426145
    Abstract: Detection of toxic gluten oligopeptides refractory to digestion and antibodies and T cells responsive thereto can be used to diagnose Celiac Sprue.
    Type: Grant
    Filed: November 4, 2011
    Date of Patent: April 23, 2013
    Assignee: The Board of Trustees of the Leland Stanford Junior University
    Inventors: Chaitan Khosla, Lu Shan
  • Enzyme Treatment of Foodstuffs for Celiac Sprue
    Publication number: 20120156253
    Abstract: Administering an effective dose of glutenase to a Celiac or dermatitis herpetiformis patient reduces levels of toxic gluten oligopeptides, thereby attenuating or eliminating the damaging effects of gluten.
    Type: Application
    Filed: November 4, 2011
    Publication date: June 21, 2012
    Inventors: Lu Shan, Michael Bethune, Chaitan Khosla, Jonathan Gass, Gail G. Pyle, Gary M. Gray, Indu Isaacs, Gregg Strohmeier
  • Diagnostic Method for Celiac Sprue
    Publication number: 20120083004
    Abstract: Detection of toxic gluten oligopeptides refractory to digestion and antibodies and T cells responsive thereto can be used to diagnose Celiac Sprue.
    Type: Application
    Filed: November 4, 2011
    Publication date: April 5, 2012
    Inventors: Chaitan Khosla, Lu Shan
  • Enzyme treatment of foodstuffs for celiac sprue
    Patent number: 8143210
    Abstract: Administering an effective dose of glutenase to a Celiac or dermatitis herpetiformis patient reduces levels of toxic gluten oligopeptides, thereby attenuating or eliminating the damaging effects of gluten.
    Type: Grant
    Filed: July 10, 2007
    Date of Patent: March 27, 2012
    Assignees: The Board of Trustees of the Leland Stanford Junior University, Alvine Pharmaceuticals, Inc.
    Inventors: Lu Shan, Chaitan Khosla
  • Diagnostic method for celiac sprue
    Patent number: 8071316
    Abstract: Detection of toxic gluten oligopeptides refractory to digestion and antibodies and T cells responsive thereto can be used to diagnose Celiac Sprue.
    Type: Grant
    Filed: July 19, 2010
    Date of Patent: December 6, 2011
    Assignee: The Board of Trustees of the Leland Stanford Junior University
    Inventors: Chaitan Khosla, Lu Shan
  • Enzyme Treatment of Foodstuffs for Celiac Sprue
    Publication number: 20110293724
    Abstract: Administering an effective dose of glutenase to a Celiac or dermatitis herpetiformis patient reduces levels of toxic gluten oligopeptides, thereby attenuating or eliminating the damaging effects of gluten.
    Type: Application
    Filed: March 21, 2011
    Publication date: December 1, 2011
    Inventors: Felix Hausch, Gary Gray, Lu Shan, Chaitan Khosla
  • Enzyme treatment of foodstuffs for celiac sprue
    Patent number: 7943312
    Abstract: Administering an effective dose of glutenase to a Celiac or dermatitis herpetiformis patient reduces levels of toxic gluten oligopeptides, thereby attenuating or eliminating the damaging effects of gluten.
    Type: Grant
    Filed: October 29, 2007
    Date of Patent: May 17, 2011
    Assignee: The Board of Trustees of the Leland Stanford Junior University
    Inventors: Felix Hausch, Gary Gray, Lu Shan, Chaitan Khosla
  • Enzyme treatment of foodstuffs for Celiac Sprue
    Patent number: 7928056
    Abstract: Administering an effective dose of glutenase to a Celiac or dermatitis herpetiformis patient reduces levels of toxic gluten oligopeptides, thereby attenuating or eliminating the damaging effects of gluten.
    Type: Grant
    Filed: October 29, 2007
    Date of Patent: April 19, 2011
    Assignee: The Board of Trustees of the Leland Stanford Junior University
    Inventors: Felix Hausch, Gary Gray, Lu Shan, Chaitan Khosla
  • Methods for diagnosing celiac sprue and reagents useful therein
    Patent number: 7923532
    Abstract: Administering an effective dose of glutenase to a Celiac or dermatitis herpetiformis patient reduces levels of toxic gluten oligopeptides, thereby attenuating or eliminating the damaging effects of gluten.
    Type: Grant
    Filed: October 29, 2007
    Date of Patent: April 12, 2011
    Assignee: The Board of Trustees of the Leland Stanford Junior University
    Inventors: Felix Hausch, Gary Gray, Lu Shan, Chaitan Khosla
  • Enzyme treatment of foodstuffs for celiac sprue
    Patent number: 7910541
    Abstract: Administering an effective dose of glutenase to a Celiac or dermatitis herpetiformis patient reduces levels of toxic gluten oligopeptides, thereby attenuating or eliminating the damaging effects of gluten.
    Type: Grant
    Filed: October 29, 2007
    Date of Patent: March 22, 2011
    Assignee: The Board of Trustees of the Leland Stanford Junior University
    Inventors: Felix Hausch, Gary Gray, Lu Shan, Chaitan Khosla