Patents by Inventor Lu Wei Liu

Lu Wei Liu has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Process for the preparation of amphiphilic poly(N-vinyl-2-pyrrolidone) block copolymers
    Patent number: 7838600
    Abstract: The instant invention provides a two-step polymerization process for preparing amphiphilic poly(N-vinyl-2-pyrrolidone), (PVP)-block-polyester copolymers and other diblock and triblock copolymers consisting of PVP as one block. The block copolymers of the invention can be used as vehicles for drug delivery.
    Type: Grant
    Filed: September 16, 2008
    Date of Patent: November 23, 2010
    Assignees: Labopharm, Inc., Labopharm Europe Limited, Labopharm (Barbados) Limited
    Inventors: Laibin Luo, David Lessard, Sandra Gori, Maxime Ranger, Yuan Wang, Julie Lafreniere, Jean-Francois Meunier, Genevieve Bibeau, Frederic Lebrun, Lu Wei Liu
  • Process for the preparation of amphiphilic poly(N-vinyl-2-pyrrolidone) block copolymers
    Publication number: 20090012240
    Abstract: The instant invention provides a two-step polymerization process for preparing amphiphilic poly(N-vinyl-2-pyrrolidone), (PVP)-block-polyester copolymers and other diblock and triblock copolymers consisting of PVP as one block. The block copolymers of the invention can be used as vehicles for drug delivery.
    Type: Application
    Filed: September 16, 2008
    Publication date: January 8, 2009
    Inventors: Laibin Luo, David Lessard, Sandra Gori, Maxime Ranger, Yuan Wang, Julie Lafreniere, Jean-Francois Meunier, Genevieve Bibeau, Frederic Lebrun, Lu Wei Liu
  • Process for the preparation of amphiphilic poly (N-vinyl-2-pyrrolidone) block copolymers
    Patent number: 7262253
    Abstract: The instant invention provides a two-step polymerization process for preparing amphiphilic poly(N-vinyl-2-pyrrolidone), (PVP)-block-polyester copolymers and other diblock and triblock copolymers consisting of PVP as one block. The block copolymers of the invention can be used as vehicles for drug delivery.
    Type: Grant
    Filed: December 2, 2003
    Date of Patent: August 28, 2007
    Assignee: Labopharm, Inc.
    Inventors: Laibin Luo, David Lessard, Sandra Gori, Maxime Ranger, Yuan Wang, Julie Lafreniere, Jean-Francois Meunier, Genevieve Bibeau, Frederic Lebrun, Lu Wei Liu
  • Process for the preparation of 1-(mercaptomethyl)-cyclopropaneacetic acid
    Patent number: 6512140
    Abstract: A process for the preparation of highly pure 1-(mercaptomethyl)-cyclopropaneacetic acid is described. Treatment of 1-(hydroxymethyl)-cyclopropaneacetonitrile with an acid provides the corresponding imino ester and/or halo-amide, which when reacted with thiourea provide the corresponding amide-isothiuronium salt. Hydrolysis of the amide-isothiuronium salt followed by an in situ oxidation allows the facile isolation and purification of 1-[1 -(carboxymethyl)-cyclopropanemethyldisulfanylmethyl]-cyclopropaneacetic acid (also known as 1-(mercaptomethyl)-cyclopropaneacetic acid disulfide). Reduction of the 1-(mercaptomethyl)-cyclopropaneacetic acid disulfide under mild conditions provides the 1-(mercaptomethyl)-cyclopropaneacetic acid with high purity.
    Type: Grant
    Filed: April 15, 2002
    Date of Patent: January 28, 2003
    Assignee: Delmar Chemicals Inc.
    Inventors: Lu Wei Liu, Yuan Wang, Hérika Marrugo, Sylvain Harper, David D. C. Quan, Zhihong (Nancy) Zhou, Gregory Bydlinski
  • Preparation of chloromethylpyridine hydrochlorides
    Patent number: 5942625
    Abstract: Chloromethylpyridine hydrochlorides such as 3-chloromethylpyridine hydrochloride, an important pharmaceutical intermediate, are prepared in high yield and high purity by reacting the corresponding pyridyl carbinol with a slight excess of thionyl chloride, in solution in an inert solvent such as toluene. The pyridyl carbinol solution is added to the thionyl chloride gradually and under its surface, to prevent the formation of impurities. The product is recovered by applying vacuum or nitrogen purge to the reaction mixture to assist precipitation, followed by filtration and washing.
    Type: Grant
    Filed: November 6, 1998
    Date of Patent: August 24, 1999
    Assignee: Delmar Chemicals
    Inventors: Yuan Wang, Lu Wei Liu, Alexandre L'Heureux, Olivier Lepage, Diane Phelan