Patents by Inventor Lu Yan

Lu Yan has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • MEK inhibiting compounds
    Publication number: 20050004186
    Abstract: This invention provides substituted Phenyl-(2-[1,3,4]thiadiazol-2-yl-phenyl)-amine and (2-[1,3,4]Oxadiazol-2-yl-phenyl)phenyl-amine compounds which act as inhibitors of MAPK/ERK Kinase (“MEK”) enzymes and pharmaceutical compositions and methods for their use in immunomodulation and in the treatment and alleviation of inflammation, and proliferative diseases such as cancer and restenosis.
    Type: Application
    Filed: December 1, 2003
    Publication date: January 6, 2005
    Inventors: Stephen Barrett, Cathlin Flamme, Michael Kaufman, Mark Plummer, Jessica Reed, Joseph Warmus, Lu-Yan Zhang
  • Substituted tetrahydroisoquinolines as C5a receptor modulators
    Patent number: 6777422
    Abstract: Substituted tetrahydroisoquinolines and related compounds are provided. Such compounds are ligands that may be used to modulate C5a receptor activity in vivo or in vitro, and are particularly useful in the treatment of conditions associated with pathological C5a receptor activation in humans, domesticated companion animals and livestock animals. Pharmaceutical compositions and methods for using them to treat such disorders are provided, as are methods for using such ligands for receptor localization studies.
    Type: Grant
    Filed: March 27, 2003
    Date of Patent: August 17, 2004
    Assignee: Neurogen Corp.
    Inventors: Kyungae Lee, Scott Mitchell, Robert Ohliger, Lu Yan Zhang, He Zhao, Kevin Currie
  • Substituted tetrahydroisoquinolines as C5a receptor modulators
    Publication number: 20040006069
    Abstract: 1
    Type: Application
    Filed: March 27, 2003
    Publication date: January 8, 2004
    Inventors: Kyungae Lee, Scott Mitchell, Robert Ohliger, Lu Yan Zhang, He Zhao, Kevin Currie
  • 5-Substituted-2-arylpyridines
    Publication number: 20030152520
    Abstract: Novel 5-substituted-2-arylpyridine compounds are provided. Such compounds can act as selective modulators of CRF receptors. The 5-substituted-2-arylpyridine compounds provided herein are useful in the treatment of a number of CNS and periphereal disorders, particularly stress, anxiety, depression, cardiovascular disorders, and eating disorders. Methods of treatment of such disorders and well as packaged pharmaceutical compositions are also provided.
    Type: Application
    Filed: May 22, 2002
    Publication date: August 14, 2003
    Applicant: Neurogen Corporation
    Inventors: Ping GE, Taeyoung Yoon, Lu Yan Zhang, Raymond F. Horvath
  • 1-heterocycle substituted diarylamines
    Patent number: 6545030
    Abstract: 1-Heterocycle substituted diarylamines, methods of making and using them, and compositions containing them.
    Type: Grant
    Filed: January 17, 2002
    Date of Patent: April 8, 2003
    Assignee: Warner-Lambert Company
    Inventors: Stephen Douglas Barrett, Alexander James Bridges, Haile Tecle, Lu-Yan Zhang
  • 1-Heterocycle substituted diarylamines
    Publication number: 20030004193
    Abstract: 1-Heterocycle substituted diarylamines, methods of making and using them, and compositions containing them.
    Type: Application
    Filed: July 23, 2002
    Publication date: January 2, 2003
    Inventors: Stephen Douglas Barrett, Alexander James Bridges, Haile Tecle, Lu-Yan Zhang