Abstract: Disclosed herein is a method of treating a viral, e.g., SARS-CoV-2, respiratory disease or infection, such as COVID-19 related pneumonia, that includes administering deuterium-enriched pirfenidone, e.g., daily for 3 months or more, such that the viral respiratory disease or infection is treated. The treating is effective in preventing the development of, halting the progression of, or slowing the progression of one or more of pulmonary fibrosis, respiratory complications of the viral respiratory disease or infection, respiratory symptoms of the viral respiratory disease or infection or pulmonary dysfunction.

Abstract: Disclosed herein are methods of treating lymphedema that include administering a clinically effective amount of deupirfenidone.

Abstract: Disclosed herein are deuterium-enriched N-Aryl pyridinone compounds, optionally in combination with one or more additional therapeutic agents, pharmaceutical compositions comprising the same, methods of preparation thereof, and methods of use thereof. Such compounds and compositions are useful, for example, in treating diseases, disorders, or conditions such as edema.

Abstract: Disclosed herein are deuterium-enriched N-Aryl pyridinone compounds, optionally in combination with one or more additional therapeutic agents, pharmaceutical compositions comprising the same, methods of preparation thereof, and methods of use thereof. Such compounds and compositions are useful, for example, in treating diseases, disorders, or conditions such as edema.

Abstract: The present invention relates to a novel method of treating hyperglycemia in a patient with poor glycemic control. The method comprises administering to the patient an effective amount of a compound described herein.

Abstract: A method of promoting sleep in a patient with overactive bladder, comprising: administering trospium chloride at or shortly before bedtime, to a patient with overactive bladder disease, in an amount sufficient to reduce wakefulness throughout the patient's normal sleep period.