Abstract: The present disclosure provides amide-based, non-nucleoside compounds having an inhibitory activity against endogenous polymerases, such as polymerase alpha and polymerase gamma. This disclosure further provides uses of treating hyperproliferative diseases or disorders, such as benign or malignant neoplasms, and more specifically cancers that are sensitive to inhibition of polymerase alpha and polymerase gamma.

Abstract: Compositions and methods for making and using modified anti-infective peptides are provided. For example, synthetically and/or recombinantly produced analogues or derivatives of naturally occurring anti-infective peptides may be efficiently modified using the compositions and methods provided herein to generate similar or identical post-translational modifications found in wild-type anti-infective peptides. The modified anti-infective peptides (e.g., antimicrobial cationic peptides) and analogues or derivatives thereof may be used, for example, in the treatment of microorganism-caused infections.