Patents by Inventor Lubertus Berrens

Lubertus Berrens has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Patent number: 6660495
    Abstract: The present invention relates to a process for the controlled enzymatic cleavage of purified and depigmented active allergenic proteins from indoor and outdoor source materials, which process produces fragments of allergens that retain the natural T-lymphocyte stimulating epitopes, but are depleted of IgE-binding B-cell epitopes and complement-activating agents. The invention also relates to the new pharmaceutical products. These allergen fragments do not exhibit the disadvantages of conventional allergenic extracts for immunotherapy and can be safely used to induce a state of specific T-cell anergy and immunological tolerance in allergic human beings.
    Type: Grant
    Filed: December 4, 2001
    Date of Patent: December 9, 2003
    Assignee: C.B.F. Leti, S.A.
    Inventors: Lubertus Berrens, Maria Leticia Gonzales Romano, Maria Teresa Gallego Camara
  • Publication number: 20020086348
    Abstract: The present invention relates to a process for the controlled enzymatic cleavage of purified and depigmented active allergenic proteins from indoor and outdoor source materials, which process produces fragments of allergens that retain the natural T-lymphocyte stimulating epitopes, but are depleted of IgE-binding B-cell epitopes and complement-activating agents. The invention also relates to the new pharmaceutical products. These allergen fragments do not exhibit the disadvantages of conventional allergenic extracts for immunotherapy and can be safely used to induce a state of specific T-cell anergy and immunological tolerance in allergic human beings.
    Type: Application
    Filed: December 4, 2001
    Publication date: July 4, 2002
    Inventors: Lubertus Berrens, Maria Leticia Gonzales Romano, Maria Teresa Gallego Camara
  • Patent number: 6350590
    Abstract: The present invention relates to a process for the controlled enzymatic cleavage of purified and depigmented active allergenic proteins from indoor and outdoor source materials, which process produces fragments of allergens that retain the the natural T-lymphocyte stimulating epitopes, but are depleted of IgE-binding B-cell epitopes and complement-activating agents. The invention also relates to the new pharmaceutical products. These allergen fragments do not exhibit the disadvantages of conventional allergenic extracts for immunotherapy and can be safely used to induce a state of specific T-cell anergy and immunological tolerance in allergic human beings.
    Type: Grant
    Filed: June 23, 2000
    Date of Patent: February 26, 2002
    Assignee: C.B.F. Leti, S.A.
    Inventors: Lubertus Berrens, Maria Leticia Gonzales Romano, Maria Teresa Gallego Camara
  • Patent number: 5770698
    Abstract: The invention concerns the removal of various allergologically irrelevant low-molecular weight components from the usual aqueous extracts of allergenically active proteins of plant pollens. Described are the desorption and subsequent elimination, from traditionally prepared allergenic pollen protein extracts, of low-molecular weight pigment and other compounds which are normally retained by strong electrostatic and/or hydrophobic forces. The preparation of such depigmented pollen proteins does not impair their allergenic potency or immunological specificity. The invention enables the production of fully active allergenic pollen proteins devoid of adhering low-molecular weight substances interfering with their safety, diagnostic accuracy and clinical efficacy. The purified pollen proteins represent improved starting materials for chemical derivatization, i.e. the preparation of attenuated vaccines for immunotherapy.
    Type: Grant
    Filed: August 14, 1995
    Date of Patent: June 23, 1998
    Assignee: C.B.F. Leti S.A.
    Inventor: Lubertus Berrens
  • Patent number: 5667979
    Abstract: It was found that atopic allergens have enzymatic properties, in particular the properties to hydrolyze amide and/or ester linkages. These properties may be used for various purposes, e.g. for analysis of samples, standardization of pharmaceutical compositions and also for the preparation of the allergens in a pure form.
    Type: Grant
    Filed: January 5, 1990
    Date of Patent: September 16, 1997
    Assignee: Laboratorios Leti S.A.
    Inventor: Lubertus Berrens
  • Patent number: 5384395
    Abstract: Primary-toxic chemical compounds with a molecular weight of less than 12000 Daltons, which may be isolated from plant material and which are potential IgE-binding allergens causing immediate-type allergy in predisposed individuals; methods for their isolation and their use for clinical purposes.
    Type: Grant
    Filed: October 22, 1991
    Date of Patent: January 24, 1995
    Assignee: Laboratorios Leti S.A.
    Inventor: Lubertus Berrens