Patents by Inventor Lubica Raptova

Lubica Raptova has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Inhibitors of JNK
    Patent number: 8536172
    Abstract: The invention relates to JNK inhibitors and corresponding methods, formulations, and compositions for inhibiting JNK and treating JNK-mediated disorders. The application discloses JNK inhibitors, as described below in Formula I: wherein p, q, Y?, r, R1, R2, X, X1, X2, X3, and X4 are as defined herein. The compounds and compositions disclosed herein are useful to modulate the activity of JNK and treat diseases associated with JNK activity. Disclosed are methods and formulations for inhibiting JNK and treating JNK-mediated disorders, and the like, with the compounds, and processes for making said compounds, and corresponding compositions, disclosed herein.
    Type: Grant
    Filed: August 9, 2010
    Date of Patent: September 17, 2013
    Assignee: Roche Palo Alto LLC
    Inventors: Leyi Gong, Xiaochun Han, Ferenc Makra, Wylie Solang Palmer, Lubica Raptova
  • JNK modulators
    Patent number: 8399462
    Abstract: Compounds of formula I modulate JNK: wherein the variables are as defined herein.
    Type: Grant
    Filed: December 7, 2007
    Date of Patent: March 19, 2013
    Assignee: Roche Palo Alto LLC
    Inventors: James Patrick Dunn, Leyi Gong, David Michael Goldstein, Xiaochun Han, Joan Heather Hogg, Wylie Solang Palmer, Lubica Raptova, Tania Silva, Parcharee Tivitmahaisoon, Teresa Alejandra Trejo-Martin, Christophe Michoud, Achyutharao Sidduri
  • Inhibitors of JNK
    Publication number: 20110034470
    Abstract: The invention relates to JNK inhibitors and corresponding methods, formulations, and compositions for inhibiting JNK and treating JNK-mediated disorders. The application discloses JNK inhibitors, as described below in Formula I: wherein p, q, Y?, r, R1, R2, X, X1, X2, X3, and X4 are as defined herein. The compounds and compositions disclosed herein are useful to modulate the activity of JNK and treat diseases associated with JNK activity. Disclosed are methods and formulations for inhibiting JNK and treating JNK-mediated disorders, and the like, with the compounds, and processes for making said compounds, and corresponding compositions, disclosed herein.
    Type: Application
    Filed: August 9, 2010
    Publication date: February 10, 2011
    Inventors: Leyi Gong, Xiaochun Han, Ferenc Makra, Wylie Solang Palmer, Lubica Raptova
  • 3-amino-1-arylpropyl indoles as monoamine reuptake inhibitors
    Patent number: 7863305
    Abstract: Compounds of formula I: or pharmaceutically acceptable salts, solvates or prodrugs thereof, wherein p, Ar, R1, R2, R3, Ra, Rb, Rc, Rd and Re are defined herein. Also provided are pharmaceutical compositions, methods of using, and methods of preparing the compounds.
    Type: Grant
    Filed: June 1, 2005
    Date of Patent: January 4, 2011
    Assignee: Roche Palo Alto LLC
    Inventors: Robert Greenhouse, Saul Jaime-Figueroa, Lubica Raptova, Deborah Carol Reuter, Karin Ann Stein, Robert Weikert
  • 3-AMINO-1-ARYLPROPYL AZAINDOLES AND USES THEREOF
    Publication number: 20100056499
    Abstract: The present invention provides compounds of the formula: or pharmaceutically acceptable salts, solvates or prodrugs thereof, wherein p, Ar, R1, R2, R3, Ra, Rb, Rc, Rd and Re are defined herein. Also provided are pharmaceutical compositions, methods of using, and methods of preparing the compounds.
    Type: Application
    Filed: November 16, 2009
    Publication date: March 4, 2010
    Inventors: Robert Greenhouse, Saul Jaime-Figueroa, Stephen M. Lynch, Lubica Raptova, Karin Ann Stein, Robert James Weikert
  • 3-Amino-1-arylpropyl azaindoles and uses thereof
    Patent number: 7638517
    Abstract: The present invention provides compounds of the formula: or pharmaceutically acceptable salts, solvates or prodrugs thereof, wherein p, Ar, R1, R2, R3, Ra, Rb, Rc, Rd and Re are defined herein. Also provided are pharmaceutical compositions, methods of using, and methods of preparing the compounds.
    Type: Grant
    Filed: November 29, 2006
    Date of Patent: December 29, 2009
    Assignee: Roche Palo Alto LLC
    Inventors: Robert Greenhouse, Saul Jaime-Figueroa, Stephen M. Lynch, Lubica Raptova, Karin Ann Stein, Robert James Weikert
  • JNK modulators
    Publication number: 20080146565
    Abstract: Compounds of formula I modulate JNK: wherein the variables are as defined herein.
    Type: Application
    Filed: December 7, 2007
    Publication date: June 19, 2008
    Inventors: James Patrick Dunn, Leyi Gong, David Michael Goldstein, Xiaochun Han, Joan Heather Hogg, Wylie Solang Palmer, Lubica Raptova, Tania Silva, Parcharee Tivitmahaisoon, Teresa Alejandra Trejo-Martin, Christophe Michoud, Achyutharao Sidduri
  • 3-Amino-1-arylpropyl azaindoles and uses thereof
    Publication number: 20070123535
    Abstract: The present invention provides compounds of the formula: or pharmaceutically acceptable salts, solvates or prodrugs thereof, wherein p, Ar, R1, R2, R3, Ra, Rb, Rc, Rd and Re are defined herein. Also provided are pharmaceutical compositions, methods of using, and methods of preparing the compounds.
    Type: Application
    Filed: November 29, 2006
    Publication date: May 31, 2007
    Inventors: Robert Greenhouse, Saul Jamie-Figueroa, Stephen Lynch, Lubica Raptova, Karin Stein, Robert Weikert
  • 3-amino-1-arylpropyl indoles as monoamine reuptake inhibitors
    Publication number: 20060025467
    Abstract: Compounds of formula I: or pharmaceutically acceptable salts, solvates or prodrugs thereof, wherein p, Ar, R1, R2, R3, Ra, Rb, Rc, Rd and Re are defined herein. Also provided are pharmaceutical compositions, methods of using, and methods of preparing the compounds.
    Type: Application
    Filed: June 1, 2005
    Publication date: February 2, 2006
    Inventors: Robert Greenhouse, Saul-Jaime Figueroa, Lubica Raptova, Deborah Reuter, Karin Stein, Robert Weikert
  • Substituted indoles as alpha-1 agonists
    Patent number: 6852726
    Abstract: This invention relates to compounds which are alpha-1 receptor agonists, preferably alpha-1A/L receptor agonists, and which are represented by Formula I: wherein X is —S(O)n— or —C(O)—, A is C1-6alkyl, aryl, heteroaryl, hydroxyalkyl, or —(CH2)p—NRaRb, and the other substituents are as defined in the specification; or individual isomers, racemic or non-racemic mixtures of isomers, or pharmaceutically acceptable salts or solvates thereof. The invention further relates to pharmaceutical compositions containing such compounds, methods for their use as therapeutic agents, and methods of preparation thereof.
    Type: Grant
    Filed: January 31, 2003
    Date of Patent: February 8, 2005
    Assignee: Syntex LLC
    Inventors: Robert Greenhouse, Saul Jaime-Figueroa, Lubica Raptova
  • Substituted indoles as alpha-1 agonists
    Publication number: 20030220319
    Abstract: This invention relates to compounds which are alpha-1 receptor agonists, preferably alpha-1A/L receptor agonists, and which are represented by Formula I: 1
    Type: Application
    Filed: January 31, 2003
    Publication date: November 27, 2003
    Inventors: Robert Greenhouse, Saul Jaime-Figueroa, Lubica Raptova