Patents by Inventor Luc Baeyens

Luc Baeyens has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • METHOD FOR GENERATING ISLET BETA CELLS FROM DEDIFFERENTIATED EXOCRINE PANCREATIC CELLS
    Publication number: 20100330049
    Abstract: The present invention relates to an in vitro method for generating insulin-producing beta cells from a population of mammalian cells comprising dedifferentiated exocrine pancreatic cells. The method comprises the step of culturing said dedifferentiated exocrine pancreatic cells in a culture medium in the presence of at least one agent that is able to inhibit the Notch 1 signaling pathway in said dedifferentiated exocrine pancreatic cells, and at least one ligand of the gp130 receptor and/or at least one ligand of the EGF receptor. The invention further provides a population of mammalian pancreatic cells comprising insulin-producing beta cells obtainable by the present method and uses thereof in a pharmaceutical composition for treating type 1 or type 2 diabetes.
    Type: Application
    Filed: February 11, 2009
    Publication date: December 30, 2010
    Inventors: Luc Bouwens, Luc Baeyens
  • Method of generating islet beta-cells from exocrine pancreatic cells
    Patent number: 7604991
    Abstract: The present invention discloses an in vitro method wherein mammalian beta-cell differentiation can be induced in dedifferentiated exocrine pancreatic cells in a medium comprising ligands of the EGF receptor and the GP130 receptor, such as EGF and LIF. Insulin secreting cells, obtainable by this method, provide a means for the treatment of diabetes by islet transplantation.
    Type: Grant
    Filed: June 21, 2004
    Date of Patent: October 20, 2009
    Assignees: Vrije Universiteit Brussel, Opus NV
    Inventors: Luc Bouwens, Luc Baeyens
  • Method Of Generating Islet Beta-Cells From Exocrine Pancreatic Cells
    Publication number: 20070292388
    Abstract: The present invention discloses an in vitro method wherein mammalian beta-cell differentiation can be induced in dedifferentiated exocrine pancreatic cells in a medium comprising ligands of the EGF receptor and the GP130 receptor, such as EGF and LIF. Insulin secreting cells, obtainable by this method, provide a means for the treatment of diabetes by islet transplantation.
    Type: Application
    Filed: June 21, 2004
    Publication date: December 20, 2007
    Applicants: VRIJE UNIVERSITEIT BRUSSEL, OPUS NV
    Inventors: Luc Bouwens, Luc Baeyens