Patents by Inventor Luc Gilbert Leybaert Sinia

Luc Gilbert Leybaert Sinia has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Use of compounds that selectively modulate astrocytic release of substances through hemichannels of connexins and pannexins, without influencing gap junctions, for the treatment of psychiatric disorders
    Patent number: 9879058
    Abstract: The present invention is related to the use of compounds or pharmaceutically acceptable salts thereof that modulate astrocytic release of substances through connexin and pannexin hemichannels, for the treatment of psychiatric disorders. Compounds or pharmaceutically acceptable salts thereof used in the present invention comprise any compound that differentially modulates, blocks, opens, inhibits, and/or activates connexin and/or pannexin hemichannels from astrocytes while not affecting gap junctions. The invention is also related to a method for treating psychiatric disorders, comprising administering to a mammal or human a therapeutically effective amount of a compound or a pharmaceutically acceptable salt thereof, that modulates astrocytic release of substances through connexin and pannexin hemichannels. Pharmaceutical compositions and a screening method are also considered in the present invention.
    Type: Grant
    Filed: May 31, 2013
    Date of Patent: January 30, 2018
    Assignees: Universidad Andres Bello, Universiteit Gent, Katholieke Universiteit Leuven, Ku Leuven R & D
    Inventors: Jimmy Stehberg Liberman, Luc Gilbert Leybaert Sinia, Geert Albert Bultynck Demets, Mauricio Antonio Retamal Lucero, Fernando Danilo Gonzalez Nilo
  • USE OF COMPOUNDS THAT SELECTIVELY MODULATE ASTROCYTIC RELEASE OF SUBSTANCES THROUGH HEMICHANNELS OF CONNEXINS AND PANNEXINS, WITHOUT INFLUENCING GAP JUNCTIONS, FOR THE TREATMENT OF PSYCHIATRIC DISORDERS
    Publication number: 20150337018
    Abstract: The present invention is related to the use of compounds or pharmaceutically acceptable salts thereof that modulate astrocytic release of substances through connexin and pannexin hemichannels, for the treatment of psychiatric disorders. Compounds or pharmaceutically acceptable salts thereof used in the present invention comprise any compound that differentially modulates, blocks, opens, inhibits, and/or activates connexin and/or pannexin hemichannels from astrocytes while not affecting gap junctions. The invention is also related to a method for treating psychiatric disorders, comprising administering to a mammal or human a therapeutically effective amount of a compound or a pharmaceutically acceptable salt thereof, that modulates astrocytic release of substances through connexin and pannexin hemichannels. Pharmaceutical compositions and a screening method are also considered in the present invention.
    Type: Application
    Filed: May 31, 2013
    Publication date: November 26, 2015
    Inventors: Jimmy Stehberg Liberman, Luc Gilbert Leybaert Sinia, Geert Albert Bultynck Demets, Mauricio Antonio Retamal Lucero, Fernando Danilo Gonzalez Nilo