Patents by Inventor Luc Jaeger

Luc Jaeger has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Hexameric tetrahedral RNA nanostructures
    Patent number: 11666663
    Abstract: Disclosed are nanostructures comprising a ribonucleic acid (RNA) scaffold comprising a hexameric tetrahedral core. The tetrahedral core may comprise four hexameric RNA nanorings linked together. Related pharmaceutical compositions, methods of modulating the expression of a target gene in a mammal, methods of treating or preventing a disease in a mammal, and methods of producing a hexameric tetrahedral RNA nanostructure are also disclosed.
    Type: Grant
    Filed: May 8, 2019
    Date of Patent: June 6, 2023
    Assignees: The United States of America,as represented by the Secretary, Department of Health and Human Services, The Regents of the University of California
    Inventors: Bruce A. Shapiro, Paul J. Zakrevsky, Luc Jaeger
  • HEXAMERIC TETRAHEDRAL RNA NANOSTRUCTURES
    Publication number: 20210069345
    Abstract: Disclosed are nanostructures comprising a ribonucleic acid (RNA) scaffold comprising a hexameric tetrahedral core. The tetrahedral core may comprise four hexameric RNA nanorings linked together. Related pharmaceutical compositions, methods of modulating the expression of a target gene in a mammal, methods of treating or preventing a disease in a mammal, and methods of producing a hexameric tetrahedral RNA nanostructure are also disclosed.
    Type: Application
    Filed: May 8, 2019
    Publication date: March 11, 2021
    Applicants: The United States of America,as represented by the Secretary,Department of Health and Human Services, The Regents of the University of California
    Inventors: Bruce A. Shapiro, Paul J. Zakrevsky, Luc Jaeger
  • RNA nanoparticles and nanotubes
    Patent number: 9732337
    Abstract: The instant invention provides polyvalent RNA nanoparticles comprising RNA motifs as building blocks that can form RNA nanotubes. The polyvalent RNA nanoparticles are suitable for therapeutic or diagnostic use in a number of diseases or disorders.
    Type: Grant
    Filed: June 16, 2010
    Date of Patent: August 15, 2017
    Assignees: The United Stated of America, as represented by the Secretary, Department of Health & Human Services, The Regents of the University of California
    Inventors: Bruce A. Shapiro, Yaroslava G. Yingling, Eckart Bindewald, Wojciech Kasprzak, Luc Jaeger, Isil Severcan, Cody Geary, Kirill Afonin
  • Co-transcriptional assembly of modified RNA nanoparticles
    Patent number: 9719084
    Abstract: A method is provided for generating RNA nanoparticles having modified nucleotides and/or having increased nuclease resistance where the RNA nanoparticles are formed cotranscriptionally by T7 RNA polymerase in the presence of manganese ions.
    Type: Grant
    Filed: September 6, 2013
    Date of Patent: August 1, 2017
    Assignees: The United States of America, as represented by the Secretary, Department of Health & Human Services, The Regents of the University of California
    Inventors: Bruce A. Shapiro, Kirill A. Afonin, Maria L. Kireeva, Mikhail Kashlev, Luc Jaeger, Wade W. Grabow
  • Auto-recognizing therapeutic RNA/DNA chimeric nanoparticles (NP)
    Patent number: 9631192
    Abstract: Auto-recognizing therapeutic R/DNA chimeric nanoparticles (R/DNA NP) are described that are pairs of DNA/RNA hybrids where the DNA molecules have complementary toehold sequences that promote the re-association of the R/DNA NPs when mixed resulting in the formation of RNA/RNA duplexes that act as siRNAs.
    Type: Grant
    Filed: November 19, 2012
    Date of Patent: April 25, 2017
    Assignees: The United States of America, as represented by the Secretary, Department of Health & Human Services, The Regents of the University of California
    Inventors: Bruce A. Shapiro, Kirill A. Afonin, Mathias D. Viard, Eckart H. Bindewald, Luc Jaeger, Arti N. Santhanam
  • THERAPEUTIC RNA SWITCHES COMPOSITIONS AND METHODS OF USE
    Publication number: 20150240238
    Abstract: The invention provides for therapeutic RNA switches comprising oligonucleotide sequences complementary to a trigger sequence, an antisense strand oligonucleotide, and a sense strand oligonucleotide complementary to a target nucleic acid molecule.
    Type: Application
    Filed: November 19, 2012
    Publication date: August 27, 2015
    Applicant: THE REGENTS OF THE UNIVERSITY OF CALIFORNIA
    Inventors: Bruce A. Shapiro, Eckart H. Bindewald, Kirill A. Afonin, Luc Jaeger, Arti N. Santhanam
  • CO-TRANSCRIPTIONAL ASSEMBLY OF MODIFIED RNA NANOPARTICLES
    Publication number: 20150203842
    Abstract: A method is provided for generating RNA nanoparticles having modified nucleotides and/or having increased nuclease resistance where the RNA nanoparticles are formed cotranscriptionally by T7 RNA polymerase in the presence of manganese ions.
    Type: Application
    Filed: September 6, 2013
    Publication date: July 23, 2015
    Inventors: Bruce A. Shapiro, Kirill A. Afonin, Maria L. Kireeva, Mikhail Kashlev, Luc Jaeger, Wade W. Grabow
  • RNA NANOPARTICLES AND NANOTUBES
    Publication number: 20120263648
    Abstract: The instant invention provides polyvalent RNA nanoparticles comprising RNA motifs as building blocks that can form RNA nanotubes. The polyvalent RNA nanoparticles are suitable for therapeutic or diagnostic use in a number of diseases or disorders.
    Type: Application
    Filed: June 16, 2010
    Publication date: October 18, 2012
    Applicants: REGENTS OF THE UNIVERSITY OF CALIFORNIA, SECRETARY, DEPARTMENT OF HEALTH AND HUMAN SERVICES
    Inventors: Bruce A. Shapiro, Yaroslava G. Yingling, Eckart Bindewald, Wojciech Kasprzak, Luc Jaeger, Isil Severcan, Cody Geary, Kirill Afonin