Patents by Inventor Luc Jozef Raphael Moens

Luc Jozef Raphael Moens has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Synthetic methods of making fused heterocyclic compounds as orexin receptor modulators
    Patent number: 12030887
    Abstract: Processes for preparing (((3aR,6aS)-5-(4,6-dimethylpyrimidin-2-yl)hexahydropyrrolo[3,4-c]pyrrol-2(1H)-yl)(2-fluoro-6-(2H-1,2,3-triazol-2-yl)phenyl) methanone are described, which are useful for commercial manufacturing. Said compound is an orexin receptor modulator and may be useful in pharmaceutical compositions and methods for the treatment of diseased states, disorders, and conditions mediated by orexin activity, such as insomnia and depression.
    Type: Grant
    Filed: November 11, 2019
    Date of Patent: July 9, 2024
    Assignee: Janssen Pharmaceutica NV
    Inventors: Dominique Paul Michel Depré, Kiran Matcha, Andy Josephina Joannes Huygaerts, Luc Jozef Raphael Moens, Dinesh Gala
  • IMPROVED SYNTHETIC METHODS OF MAKING FUSED HETEROCYCLIC COMPOUNDS AS OREXIN RECEPTOR MODULATORS
    Publication number: 20220009932
    Abstract: Processes for preparing (((3aR,6aS)-5-(4,6-dimethylpyrimidin-2-yl)hexahydropyrrolo[3,4-c]pyrrol-2(1H)-yl)(2-fluoro-6-(2H-1,2,3-triazol-2-yl)phenyl) methanone are described, which are useful for commercial manufacturing. Said compound is an orexin receptor modulator and may be useful in pharmaceutical compositions and methods for the treatment of diseased states, disorders, and conditions mediated by orexin activity, such as insomnia and depression.
    Type: Application
    Filed: November 11, 2019
    Publication date: January 13, 2022
    Inventors: Dominique Paul Michel DEPRÉ, Kiran MATCHA, Andy Josephina Joannes HUYGAERTS, Luc Jozef Raphael MOENS, Dinesh GALA
  • HIV INHIBITING 2-(4-CYANOPHENYLAMINO) PYRIMIDINE DERIVATIVES
    Publication number: 20090124644
    Abstract: HIV replication inhibitors of formula pharmaceutically acceptable addition salts or stereochemically isomeric forms thereof, wherein X is NR4, S, SO or SO2; the preparation of these compounds as well as pharmaceutical compositions comprising these compounds; the use of these compounds for the prevention or the treatment of HIV infection.
    Type: Application
    Filed: January 27, 2006
    Publication date: May 14, 2009
    Applicant: JANSSEN PHARMACEUTICA N.V.
    Inventors: Jan Heeres, Paulus Joannes Lewi, Paul Adriaan Jan Janssen, Frank Xavier Jozef Herwig Arts, Rudolf Leemans, Luc Jozef Raphael Moens
  • Synthesis of cisapride
    Patent number: 6218542
    Abstract: A new Process of preparing cisapride, and the pharmaceutically acceptable acid addition salts thereof, by reductively aminating 1-[3-(4-fluorophenoxy)-propyl]-3-methoxy-4-piperidinone in the presence of benzylamine under hydrogen in a reaction-inert solvent, yielding 1-[3-(4-fluorophenoxy)-propyl]-3-methoxy-4-piperidinamine having a cis/trans ratio of about 93/7, which is enriched in the amount of cis-stereoisomer by converting it into its acid addition salt, by treatment with a suitable inorganic acid, in an appropriate solvent, subsequent crystallisation and conversion to its free base form by treatment with an appropriate base, yielding 1-[3-(4-fluorophenoxy)-propyl]-3-methoxy-4-piperidinamine having a cis/trans ratio of equal to or higher than 98/2.
    Type: Grant
    Filed: April 14, 1999
    Date of Patent: April 17, 2001
    Assignee: Jenssen Pharmaceutica N.V.
    Inventors: Alfons Gaston Maria De Knaep, Luc Jozef Raphael Moens, Max Rey