Patents by Inventor Luc Lebreton
Luc Lebreton has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Publication number: 20210128911Abstract: An electroporation device for injecting a product into a ciliary muscle of an eye includes a support having a spherical support contact surface extending along a virtual sphere having a radius between 10 and 15 mm, a first electrode comprising a curved invasive electrode needle, a second electrode having an electrically conductive electrode contact surface, and an injection needle.Type: ApplicationFiled: January 8, 2021Publication date: May 6, 2021Applicant: EYEVENSYSInventors: Luc LEBRETON, Elodie TOUCHARD, Romain BENARD, Karine BIGOT, Cécile MADARAS, Francine BEHAR-COHEN
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Patent number: 10912939Abstract: An electroporation device for injecting a product into a ciliary muscle of an eye, said device comprising: a support having a support contact surface extending along a virtual sphere having a radius between 10 and 15 mm, so as to match the outside surface of the eye, a first electrode comprising an invasive electrode needle, a second electrode having an electrically conductive electrode contact surface, optionally an injection needle, wherein the support comprises an insertion guide configured to guide a sliding of said electrode needle and/or injection needle along a respective insertion axis, so that the angle between said insertion axis and a plane tangential to the virtual sphere at the insertion point is less than 40°, the insertion point being the point where said insertion axis crosses said virtual sphere.Type: GrantFiled: April 13, 2016Date of Patent: February 9, 2021Assignee: EYEVENSYSInventors: Luc Lebreton, Elodie Touchard, Romain Benard, Karine Bigot, Cécile Madaras, Francine Behar-Cohen
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Publication number: 20180289958Abstract: An electroporation device for injecting a product into a ciliary muscle of an eye, said device comprising: a support having a support contact surface extending along a virtual sphere having a radius between 10 and 15 mm, so as to match the outside surface of the eye, a first electrode comprising an invasive electrode needle, a second electrode having an electrically conductive electrode contact surface, optionally an injection needle, wherein the support comprises an insertion guide configured to guide a sliding of said electrode needle and/or injection needle along a respective insertion axis, so that the angle between said insertion axis and a plane tangential to the virtual sphere at the insertion point is less than 40°, the insertion point being the point where said insertion axis crosses said virtual sphere.Type: ApplicationFiled: April 13, 2016Publication date: October 11, 2018Applicant: EYEVENSYSInventors: Luc LEBRETON, Elodie TOUCHARD, Romain BENARD, Karine BIGOT, Cécile MADARAS, Francine BEHAR-COHEN
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Publication number: 20130190278Abstract: The present invention relates to the use of the compounds of formula (I) and their pharmaceutically acceptable salts for the treatment or the prevention of ocular inflammatory diseases, in particular for the treatment and/or prevention of uveitis, severe conjunctivitis, dry eye syndrome or diabetic retinopathy.Type: ApplicationFiled: July 8, 2011Publication date: July 25, 2013Applicant: Laboratoires Fournier SAInventors: Jocelyne Annat, Hélène-Céline Huguet, Olivier Lacombe, Luc Lebreton
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Patent number: 7872021Abstract: Benzenesulfonamide derivative compounds corresponding to the general formula (I): and their pharmaceutically acceptable addition salts; a process for preparation of such compounds; pharmaceutical compositions containing such compounds, and the use of such compounds as a pharmacologically active substance, in particular in the treatment of neurodegenerative diseases, cardiovascular diseases, inflammatory diseases; hypercholesterolemia, and diabetes.Type: GrantFiled: November 7, 2006Date of Patent: January 18, 2011Assignee: Laboratories Fournier S.A.Inventors: Luc Lebreton, Christine Massardier, Christine Dumas, Pierre Dodey, Philippe Masson
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Patent number: 7465811Abstract: Sulfonylindoline compounds of formula I, wherein R1 through R4, Y and Z have defined meanings, a process for preparation of such compounds, and the use as pharmaceutically active substances, particularly for the treatment or inhibition of neurodegeneration, cardiovascular disease, inflammatory disease, hypercholesterolemia, dyslipidemia, obesity or diabetes.Type: GrantFiled: November 30, 2007Date of Patent: December 16, 2008Assignee: Laboratoires Fournier S.A.Inventors: Luc Lebreton, Christine Dumas, Christine Massardier, Michel Bondoux
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Publication number: 20080119465Abstract: Sulfonylindoline compounds of formula I, wherein R1 through R4, Y and Z have defined meanings, a process for preparation of such compounds, and the use as pharmaceutically active substances, particularly for the treatment or inhibition of neurodegeneration, cardiovascular disease, inflammatory disease, hypercholesterolemia, dyslipidemia, obesity or diabetes.Type: ApplicationFiled: November 30, 2007Publication date: May 22, 2008Applicant: Laboratories Fournier S.A.Inventors: Luc LEBRETON, Christine Dumas, Christine Massardier, Michel Bondoux
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Publication number: 20070099960Abstract: Benzenesulfonamide derivative compounds corresponding to the general formula (I): and their pharmaceutically acceptable addition salts; a process for preparation of such compounds; pharmaceutical compositions containing such compounds, and the use of such compounds as a pharmacologically active substance, in particular in the treatment of neurodegenerative diseases, cardiovascular diseases, inflammatory diseases; hypercholesterolemia, and diabetes.Type: ApplicationFiled: November 7, 2006Publication date: May 3, 2007Applicant: Laboratoires Fournier S.A.Inventors: Luc Lebreton, Christine Massardier, Christine Dumas, Pierre Dodey, Philippe Masson
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Publication number: 20030139349Abstract: The invention concerns (i) [4-(4-cyanobenzyl)phenyl]&agr;-D-glycopyranosides of formula (I) wherein: the group &agr;-D-glycopyranosyl R represents a &agr;-D-glycopyranosyl, &agr;-D-galactopyranosyl. &agr;-D-mannopyranosyl, &agr;-D-arabinopyranosyl, &agr;-D-lyxopyranosyl, or &agr;-D-ribopyranosyl group: (ii) their esters resulting from the esterification of at least a OH function of each pyranosyl group with a C2-C4 alkanoic or a cycloalkanoic acid, as novel industrial products. Said novel [4-(4-cyanobenzyl)phenyl]&agr;-D-glycopyranosides are useful in therapy for fighting against atheromatous plaque.Type: ApplicationFiled: September 5, 2002Publication date: July 24, 2003Inventors: Luc Lebreton, Christiane Legendre, Soth Samreth
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Publication number: 20030100515Abstract: The invention concerns: (i) [4-(4-cyanobenzyl)phenyl]glycopyranosides of formula (I) wherein; the glycopyranosyl group R represents a &bgr;-D arabinopyranosyl, &bgr;-D-lyxopyranosyl, &bgr;-D-ribopyranosyl, &bgr;-D-mannopyranosyl, &bgr;-L-arabinopyranosyl, &bgr;-L-xylopyranosyl, &agr;-L-arabinopyranosyl, &agr;-L-xylopyranosyl or &bgr;-L-rhamnopyranosyl group; and (ii) their esters resulting from esterification of at least a OH function of each glycopyranosyl group with a C2-C4 alkanoic or cycloalkanoic acid, as novel industrial products. Said novel [4-(4-cyanobenzyl)phenyl]glycopyranosides are useful in therapy for fighting against athermatous plaque.Type: ApplicationFiled: September 6, 2002Publication date: May 29, 2003Inventors: Luc Lebreton, Christiane Legendre, Soth Samreth
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Patent number: 5883132Abstract: The present invention relates to compounds selected from the group consisting of:(i) the compounds of the formula ##STR1## in which: R is a hydrogen atom, a group OH, a group OCH.sub.3 or a group CH.sub.2 OH,*C, in the case where R is not a hydrogen atom, is an asymmetric carbon atom of (R,S), (R) or (S) configuration, and**C is an asymmetric carbon atom of (R,S) or (R) configuration; and(ii) their addition salts.It further relates to the method of preparing these compounds, to their use in therapeutics and in the field of analysis, and to intermediates.Type: GrantFiled: October 10, 1996Date of Patent: March 16, 1999Assignee: Fournier Industrie Et SanteInventors: Luc Lebreton, Patrice Renaut, Philippe Durand
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Patent number: 5733928Abstract: The present invention relates to a novel compound selected from the group consisting of:(i) the compounds of the formula ##STR1## in which: A is a group --CO--NH-- or a group --NH--CO--,R is a hydrogen atom or a methyl group, and*C, if R is not the hydrogen atom, is an asymmetric carbon of (R,S) or (R) configuration; and(ii) their addition salts.It further relates to the method of preparing this compound and to its use in therapeutics.Type: GrantFiled: May 15, 1996Date of Patent: March 31, 1998Assignee: Fournier Industrie et SanteInventors: Luc Lebreton, Patrice Renaut, Christine Dumas
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Patent number: 5637613Abstract: The present invention relates, by way of novel industrial products, to compounds which are structurally related to 15-deoxyspergualin and which have the formula ##STR1## in which: A is a single bond, a group --CH.sub.2 --, a group --CH.sub.2 O--, a group --CH.sub.2 NH--, a group --CH(OH)--, a group --CHF-- or a group --CH(OCH.sub.3)--, andn is equal to 6 or 8,and their addition salts.These novel compounds are useful especially as immunosuppressants. The invention further relates to the method of preparing said compounds.Type: GrantFiled: February 23, 1995Date of Patent: June 10, 1997Assignee: Fournier Industrie et SanteInventors: Patrice Renaut, Luc Lebreton, Patrick Dutartre, Soth Samreth, Catherine Derrepas, Jean M. Rognon
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Patent number: 5476870Abstract: The present invention relates, by way of novel industrial products, to compounds which are structurally related to 15-deoxyspergualin. These novel compounds have the formula ##STR1## in which: n is equal to 6 or 8 andA is a single bond, CH.sub.2, CHF, CH(OH), CH(OCH.sub.3), CH.sub.2 NH or CH.sub.2 O,and their addition salts.Type: GrantFiled: December 2, 1993Date of Patent: December 19, 1995Assignee: Fournier Industrie ET SanteInventors: Patrice Renaut, Luc Lebreton, Patrick Dutartre, Philippe Derrepas, Soth Samreth
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Patent number: 5250551Abstract: Compounds for therapeutic use of formula: ##STR1## where the chain--W--V--N--represents--N.dbd.N--N--, --N--N.dbd.N--,--O--CO--N--,--O--CS--N--, --S--CO--N--or--S--CS--N--; Ar is an aryl group; and A is a vinyl group or an alkylene chain terminated by CN, methoxy, ethoxy, OH, halogen or NH.sub.2 which may possibly be substituted.Type: GrantFiled: January 3, 1992Date of Patent: October 5, 1993Assignee: Delalande S.A.Inventors: Rene L. Milcent, Luc Lebreton, Fathi Mazouz, Claude Burstein, Salah Gueddari
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Patent number: 5100910Abstract: Compounds for therapeutic use of formula: ##STR1## where the chain--W--V--N--represents--N.dbd.N--N--, --N--N.dbd.N--, --O--CO--N--, --O--CS--N--, --S--CO--N-- or --S--CS--N--; Ar is an aryl group; and A is a vinyl group or an alkylene chain terminated by CN, methoxy, ethoxy, OH, halogen or NH.sub.2 which may possibly be substituted.Type: GrantFiled: May 25, 1989Date of Patent: March 31, 1992Assignee: Delalande S.A.Inventors: Rene L. Milcent, Luc Lebreton, Fathi Mazouz, Claude Burstein, Salah Gueddari