Patents by Inventor Luc Reymond

Luc Reymond has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Patent number: 12018157
    Abstract: The invention relates to a compound characterized by general formula (100), wherein R1 and R6 are H or F, R2, R3, R4 and R5 can be any substituent, R7, R8, RN1, RN2, RN3 and RN4 are a hydrocarbon moiety, one of R9 and R10 is hydrogen and the other one is hydrogen or a saturated carbon atom connected to any substituent, and its use in staining and live cell fluorescence imaging.
    Type: Grant
    Filed: December 20, 2018
    Date of Patent: June 25, 2024
    Assignee: SPIROCHROME AG
    Inventors: Kai Johnsson, Luc Reymond, Michelle Frei, Stefan Pitsch
  • Publication number: 20230147145
    Abstract: The invention relates to a compound characterized by general formula (100), wherein R1 and R6 are H or F, R2, R3, R4 and R5 can be any substituent, R7, R8, RN1, RN2, RN3 and RN4 are a hydrocarbon moiety, one of R9 and R10 is hydrogen and the other one is hydrogen or a saturated carbon atom connected to any substituent, and its use in staining and live cell fluorescence imaging.
    Type: Application
    Filed: December 20, 2018
    Publication date: May 11, 2023
    Applicant: SPIROCHROME AG
    Inventors: Kai JOHNSSON, Luc REYMOND, Michelle FREI, Stefan PITSCH
  • Patent number: 10221439
    Abstract: The invention relates to the in vitro and in cellulo detection of the cofactors nicotinamide adenine dinucleotide (NAD) and nicotinamide adenine dinucleotide phosphate (NADP). Provided is a sensor molecule for fluorescence- or luminescence-based detection of a nicotinamide adenine dinucleotide analyte, in particular for detecting the concentrations of NAD+, NADP+ and/or the ratios of the concentrations of NAD+/NADH and NADP+/NADPH, the sensor comprising (i) a binding protein (BP) for the nicotinamide adenine dinucleotide analyte, the BP being derived from sepiapterin reductase (SPR; EC 1.1.1.153) (ii) an SPR ligand (SPR-L) capable of intramolecular binding to said BP in the presence of the oxidized form of said analyte; and (iii) at least one fluorophore.
    Type: Grant
    Filed: February 16, 2016
    Date of Patent: March 5, 2019
    Assignee: Max-Planck-Gesellschaft zur Förderung der Wissenschaften e.V.
    Inventors: Olivier Sallin, Luc Reymond, Kai Peter Johnsson
  • Publication number: 20180087083
    Abstract: The invention relates to the in vitro and in cellulo detection of the cofactors nicotinamide adenine dinucleotide (NAD) and nicotinamide adenine dinucleotide phosphate (NADP). Provided is a sensor molecule for fluorescence or luminescence-based detection of a nicotinamide adenine dinucleotide analyte, in particular for detecting the concentrations of NAD+, NADP? and/or the ratios of the concentrations of NAD?/NAD H and NADP?/NADPH, the sensor comprising (i) a binding protein (BP) for the nicotinamide adenine dinucleotide analyte, the BP being derived from sepiapterin reductase (SPR; EC 1.1.1.153) (ii) a SPR ligand (SPR-L) capable of intramolecular binding to said BP in the presence of the oxidized form of said analyte; and (iii) at least one fluorophore.
    Type: Application
    Filed: February 16, 2016
    Publication date: March 29, 2018
    Inventors: Olivier SALLIN, Luc REYMOND, Kai Peter JOHNSSON
  • Patent number: 8859749
    Abstract: The present invention refers to a double-stranded siRNA molecule comprising a sense Strand and an antisense Strand which is essentially complementary to the sense Strand, each of the sense and the antisense Strands comprising at least 17 nucleotides (nt), the siRNA further comprising at least one overhang at the 5? and/or 3? end, wherein the overhang residue or overhang residues are chemically modified and selected independently from each other from the group consisting of: (a) 2?-deoxy modified nucleotides; (b) 2?-methoxy modified nucleotides; (c) two nucleosides linked by a 3? to 5? or 2? to 5? formacetal linkage; (d) nucleotides modified at the 2?-position by a —O—CH2—O—(CH2)2—OH group; and (e) nucleotides comprising in the 3?-position a —CH2—O—(CH2)7—CH3 group.
    Type: Grant
    Filed: March 8, 2006
    Date of Patent: October 14, 2014
    Assignee: QIAGEN GmbH
    Inventors: Ioanna Andreou, Stefan Pitsch, Evelyne Muller, Luc Reymond
  • Publication number: 20090197332
    Abstract: The present invention refers to a double-stranded siRNA molecule comprising a sense Strand and an antisense Strand which is essentially complementary to the sense Strand, each of the sense and the antisense Strands comprising at least 17 nucleotides (nt), the siRNA further comprising at least one overhang at the 5? and/or 3? end, wherein the overhang residue or overhang residues are chemically modified and selected independently from each other from the group consisting of: (a) 2?-deoxy modified nucleotides; (b) 2?-methoxy modified nucleotides; (c) two nucleosides linked by a 3? to 5? or 2? to 5? formacetal linkage; (d) nucleotides modified at the 2?-position by a -0-CH2—O—(CH2)2—OH group; and (e) nucleotides comprising in the 3?-position a —CH2—O—(CH2)7—CH3 group.
    Type: Application
    Filed: March 8, 2006
    Publication date: August 6, 2009
    Inventors: Ioanna Andreou, Stefan Pitsch, Evelyne Muller, Luc Reymond