Abstract: The present disclosure relates to novel macrocyclic compounds and libraries thereof that are useful as research tools for drug discovery efforts. This disclosure also relates to methods of preparing these compounds and libraries and methods of using these libraries, such as in high throughput screening. In particular, these libraries are useful for evaluation of bioactivity at existing and newly identified pharmacologically relevant targets, including G protein-coupled receptors, nuclear receptors, enzymes, ion channels, transporters, transcription factors, protein-protein interactions and nucleic acid-protein interactions. As such, these libraries can be applied to the search for new pharmaceutical agents for the treatment and prevention of a range of medical conditions.

Abstract: The present disclosure relates to novel macrocyclic compounds and libraries thereof containing heteroaryl moieties that are useful as research tools for drug discovery efforts. The present disclosure also relates to methods of preparing these compounds and libraries and methods of using these libraries, such as in high throughput screening. In particular, these libraries are useful for evaluation of bioactivity at existing and newly identified pharmacologically relevant targets, including G protein-coupled receptors, nuclear receptors, enzymes, ion channels, transporters, transcription factors, protein-protein interactions and nucleic acid-protein interactions. As such, these libraries can be applied to the search for new pharmaceutical agents for the treatment and prevention of a range of medical conditions.

Abstract: Examples herein relate to monitoring network performance. For example, a system includes a topology map engine and service quality indicator (SQI) engine. The topology map engine develops a topology map representing multiple nodes irrespective of a type of domain. The SQI engine determines service quality indicators corresponding to the multiple nodes and updates the topology map with the service quality indicators.

Abstract: A mechanism comprises a first Halbach cylinder having an inner cavity, the first Halbach cylinder magnetized to produce a first magnetic flux concentrated circumferentially inside the inner cavity. A second Halbach cylinder is concentrically received in the inner cavity of the first Halbach cylinder to concurrently form a rotational joint having a rotational axis. One of the Halbach cylinders is a rotor and the other of the Halbach cylinders is a stator, the second Halbach cylinder magnetized to produce a second magnetic flux concentrated circumferentially outwardly. An output is connected to the rotor to rotate therewith relative to the stator, the output applying a gravity load on the rotor, the gravity load being offset from the rotational axis, whereby the magnetic flux of the first Halbach cylinder and the second Halbach cylinder cooperatively produce a torque against the gravity load caused by the output.

Abstract: A method for delivering the services of automatic service level agreements includes receiving a customer's selection through a service manager portal of a number of services offered by a number of third-party service providers; and invoking underlying contracts with the number of third-party service providers that correspond to the selected services. The underlying contracts are modified when created based on an evaluation of each of the third-party service providers.

Abstract: A robot for machining a part of structure under water, comprising a machine tool having a chamber receiving a machining element, a support and guiding structure of the machine tool fixable with respect to the part to be machined and having submersible mobile elements and corresponding submersible guiding elements defining axes along which the mobile elements are movable to position the machine tool with respect to the part to be machined, displacement units for displacement of the mobile elements along the axes, a gas supply connecting to the machine tool to inject gas in the chamber, and a programmable control unit for operating the displacement units and the machine tool based on a closed-loop control mode in order to achieve the machining of the part.

Abstract: A robot for machining a part of structure under water, comprising a machine tool having a chamber receiving a machining element, a support and guiding structure of the machine tool fixable with respect to the part to be machined and having submersible mobile elements and corresponding submersible guiding elements defining axes along which the mobile elements are movable to position the machine tool with respect to the part to be machined, displacement units for displacement of the mobile elements along the axes, a gas supply connecting to the machine tool to inject gas in the chamber, and a programmable control unit for operating the displacement units and the machine tool based on a closed-loop control mode in order to achieve the machining of the part.

Abstract: A system and method automates and simplifies tasks associated with setting up a user self-activating network-based service. A configurable input engine is configured to define the service. The service may, for example, use a plurality of networking devices and/or computing devices. After the service is defined, an offer of the service is published to a user. The offer includes values of commercial terms and/or values of configuration parameters associated with the offer. Upon receiving an acceptance of the offer from the user, the configurable input engine automatically generates activations for the devices to be used by the service. The activations are sent to policy distribution points (PDPs) where the activations are translated into device-specific instructions. The device-specific instructions are in turn sent to the devices (networking devices and/or computing devices) to be configured. The device-specific instructions configure the devices, thereby automatically setting up the service for the user.

Abstract: The present invention provides a magnetic resonance imaging system making use of low resolution, whole-body plan scan image of a body. The whole-body plan scan image is exploited to gather a plurality of individual information of a body that is essential for an optimization of acquisition parameter for acquisition of a high resolution and high quality image of a region of interest of the body. Moreover, the whole-body plan scan image is used in order to facility a determination and a selection of a region of interest to be performed by an operator. Additionally, the MRI provides effective means for autonomously identifying specific body parts or even organs of a patient. Providing the entire information that can be extracted from the whole-body plan scan image to the operator effectively simplifies the workflow of the operator in an intuitive way.

Abstract: The present invention is directed to processes for the preparation of hydroxy-substituted aryl sulfamide derivatives of the formula I or pharmaceutically acceptable salts, stereoisomers or tautomers thereof, which are monoamine reuptake inhibitors wherein the constituent variables are as defined herein.

Abstract: A “policy distribution point” (PDP) allows service drivers to be installed remotely and automatically without rebooting the PDP or otherwise interrupting existing network-based services. The exposure of sensitive configuration data to non-secure networks is minimized by placing PDPs close to the devices to be configured. Service drivers on the PDP can be reused to configure multiple devices of the same type. The PDP receives an “activation” and uses a service driver on the PDP to translate the activation into “device-specific instructions.” The device-specific instructions are sent to a device and configure the device to set up the network-based service. One or more PDPs can be used to configure both computing device and networking devices to provide a single service.

Abstract: A “policy distribution point” (PDP) allows service drivers to be installed remotely and automatically without rebooting the PDP or otherwise interrupting existing network-based services. The exposure of sensitive configuration data to non-secure networks is minimized by placing PDPs close to the devices to be configured. Service drivers on the PDP can be reused to configure multiple devices of the same type. The PDP receives an “activation” and uses a service driver on the PDP to translate the activation into “device-specific instructions.” The device-specific instructions are sent to a device and configure the device to set up the network-based service. One or more PDPs can be used to configure both computing device and networking devices to provide a single service.

Abstract: A “policy distribution point” (PDP) allows service drivers to be installed remotely and automatically without rebooting the PDP or otherwise interrupting existing network-based services. The exposure of sensitive configuration data to non-secure networks is minimized by placing PDPs close to the devices to be configured. Service drivers on the PDP can be reused to configure multiple devices of the same type. The PDP receives an “activation” and uses a service driver on the PDP to translate the activation into “device-specific instructions.” The device-specific instructions are sent to a device and configure the device to set up the network-based service. One or more PDPs can be used to configure both computing device and networking devices to provide a single service.

Abstract: A system and method automates and simplifies tasks associated with setting up a user self-activating network-based service. A configurable input engine is configured to define the service. The service may, for example, use a plurality of networking devices and/or computing devices. After the service is defined, an offer of the service is published to a user. The offer includes values of commercial terms and/or values of configuration parameters associated with the offer. Upon receiving an acceptance of the offer from the user, the configurable input engine automatically generates activations for the devices to be used by the service. The activations are sent to policy distribution points (PDPs) where the activations are translated into device-specific instructions. The device-specific instructions are in turn sent to the devices (networking devices and/or computing devices) to be configured. The device-specific instructions configure the devices, thereby automatically setting up the service for the user.

Abstract: A system and method automates and simplifies tasks associated with setting up a user self-activating network-based service. A configurable input engine is configured to define the service. The service may, for example, use a plurality of networking devices and/or computing devices. After the service is defined, an offer of the service is published to a user. The offer includes values of commercial terms and/or values of configuration parameters associated with the offer. Upon receiving an acceptance of the offer from the user, the configurable input engine automatically generates activations for the devices to be used by the service. The activations are sent to policy distribution points (PDPs) where the activations are translated into device-specific instructions. The device-specific instructions are in turn sent to the devices (networking devices and/or computing devices) to be configured. The device-specific instructions configure the devices, thereby automatically setting up the service for the user.

Abstract: A network-based service creation platform automates and simplifies many tasks associated with defining new network service offerings to network users, publishing the new service offerings to the users, handling the subscription and registration of subscribers to the new service, billing for the service, and otherwise managing the service. In one embodiment, once a user is authenticated a first time, the user is then automatically authenticated for multiple network-based services without having to perform separate manual logins for each service. Moreover, the user is authenticated for a plurality of networking devices and/or computing devices used to provide the services.

Abstract: A system and method automates and simplifies tasks associated with setting up a user self-activating network-based service. A configurable input engine is configured to define the service. The service may, for example, use a plurality of networking devices and/or computing devices. After the service is defined, an offer of the service is published to a user. The offer includes values of commercial terms and/or values of configuration parameters associated with the offer. Upon receiving an acceptance of the offer from the user, the configurable input engine automatically generates activations for the devices to be used by the service. The activations are sent to policy distribution points (PDPs) where the activations are translated into device-specific instructions. The device-specific instructions are in turn sent to the devices (networking devices and/or computing devices) to be configured. The device-specific instructions configure the devices, thereby automatically setting up the service for the user.

Abstract: A “policy distribution point” (PDP) allows service drivers to be installed remotely and automatically without rebooting the PDP or otherwise interrupting existing network-based services. The exposure of sensitive configuration data to non-secure networks is minimized by placing PDPs close to the devices to be configured. Service drivers on the PDP can be reused to configure multiple devices of the same type. The PDP receives an “activation” and uses a service driver on the PDP to translate the activation into “device-specific instructions.” The device-specific instructions are sent to a device and configure the device to set up the network-based service. One or more PDPs can be used to configure both computing device and networking devices to provide a single service.

Abstract: The invention relates to a process for optimizing accesses to a database. This process allows client applications to request a CMIS-DB server, via an online configuration, to customize the generic representation for the object classes for which the access times must be optimized in order to reduce the search times for the object instances selected, by performing a step for configuring the physical storage of an object class to be optimized, which consists in the creation of an object instance of the storage definition class (mocStorageDefinition), in which are declared the attribute or attributes of the class to be optimized, which will be indexed when physically stored on a disk.

Abstract: In a structure comprising a first, through-shaped reflector and a second reflector consisting of two parabolic portions derived from a parabola of which the axis forms a certain angle with the main axis of waveflux emission of the device, the two parabolic portions are so shaped and disposed as to have a certain symmetry in relation to the main axis of the emergent beam, so that a secondary emission can be obtained in a privileged direction other than that of the main beam axis.