Patents by Inventor Luca Caucci
Luca Caucci has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Publication number: 20230386039Abstract: Many biologic processes taking place inside a living organism are unpredictable in time and space, and cannot be known exactly. These mechanisms and interactions among them are better modeled as physiological random processes, the statistics of which are fully described by joint characteristic functionals. The present invention provides methods for the estimation of joint characteristic functionals through imaging of multiple physiological random processes. This technology can be used to study complex diseases, such as tumors and viral infections, by imaging the biological processes involved with disease progression and response to treatment.Type: ApplicationFiled: October 22, 2021Publication date: November 30, 2023Applicant: Arizona Board of Regents on Behalf of the University of ArizonaInventors: Luca CAUCCI, Harrison H. BARRETT
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Publication number: 20220187181Abstract: The present invention provides autoradiography methods and systems for imaging via the detection of alpha particles, beta particles, or other charged particles. Embodiments of the methods and systems provide high-resolution 3D imaging of the distribution of a radioactive probe, such as a radiopharmaceutical, on a tissue sample. Embodiments of the present methods and systems provide imaging of tissue samples by reconstruction of a 3D distribution of a source of particles, such as a radiopharmaceutical. Embodiments of the methods and systems provide tomographic methods including microtomography, macrotomography, cryomicrotomography and cryomacrotomography.Type: ApplicationFiled: October 20, 2021Publication date: June 16, 2022Applicants: Arizona Board of Regents on Behalf of the University of Arizona, inviCro, LLCInventors: Harrison H. BARRETT, Yijun DING, Luca CAUCCI, John William HOPPIN
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Patent number: 11249000Abstract: The present invention provides autoradiography methods and systems for imaging via the detection of alpha particles, beta particles, or other charged particles. Embodiments of the methods and systems provide high-resolution 3D imaging of the distribution of a radioactive probe, such as a radiopharmaceutical, on a tissue sample. Embodiments of the present methods and systems provide imaging of tissue samples by reconstruction of a 3D distribution of a source of particles, such as a radiopharmaceutical. Embodiments of the methods and systems provide tomographic methods including microtomography, macrotomography, cryomicrotomography and cryomacrotomography.Type: GrantFiled: October 15, 2019Date of Patent: February 15, 2022Assignees: Arizona Board of Regents on Behalt of the University of Arizona, inviCro, LLCInventors: Harrison H. Barrett, Yijun Ding, Luca Caucci, John William Hoppin
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Patent number: 10591353Abstract: The present invention provides methods and systems for manipulating radiance data obtained from a radiance sensor that includes a lenslet array and a photodetector array, where the manipulation of the radiance data uses one or more algorithms or mathematical transformations applied by a software program. Manipulating the measured radiance data computationally produces the same optical effects of a desired optical system without having to insert the optical system into the optical path of the electromagnetic radiation. The manipulated radiance data is then used to generate an image.Type: GrantFiled: February 10, 2019Date of Patent: March 17, 2020Assignee: Arizona Board of Regents on behalf of The University of ArizonaInventors: Luca Caucci, Harrison Barrett
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Publication number: 20200049607Abstract: The present invention provides autoradiography methods and systems for imaging via the detection of alpha particles, beta particles, or other charged particles. Embodiments of the methods and systems provide high-resolution 3D imaging of the distribution of a radioactive probe, such as a radiopharmaceutical, on a tissue sample. Embodiments of the present methods and systems provide imaging of tissue samples by reconstruction of a 3D distribution of a source of particles, such as a radiopharmaceutical. Embodiments of the methods and systems provide tomographic methods including microtomography, macrotomography, cryomicrotomography and cryomacrotomography.Type: ApplicationFiled: October 15, 2019Publication date: February 13, 2020Applicants: Arizona Board of Regents on Behalf of the University of Arizona, inviCro, LLCInventors: Harrison H. BARRETT, Yijun DING, Luca CAUCCI, John William HOPPIN
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Patent number: 10444136Abstract: The present invention provides autoradiography methods and systems for imaging via the detection of alpha particles, beta particles, or other charged particles. Embodiments of the methods and systems provide high-resolution 3D imaging of the distribution of a radioactive probe, such as a radiopharmaceutical, on a tissue sample. Embodiments of the present methods and systems provide imaging of tissue samples by reconstruction of a 3D distribution of a source of particles, such as a radiopharmaceutical. Embodiments of the methods and systems provide tomographic methods including microtomography, macrotomography, cryomicrotomography and cryomacrotomography.Type: GrantFiled: November 11, 2015Date of Patent: October 15, 2019Assignees: Arizona Board of Regents on Behalf of the University of Arizona, InviCro, LLCInventors: Harrison H. Barrett, Yijun Ding, Luca Caucci, John William Hoppin
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Publication number: 20190170575Abstract: The present invention provides methods and systems for manipulating radiance data obtained from a radiance sensor that includes a lenslet array and a photodetector array, where the manipulation of the radiance data uses one or more algorithms or mathematical transformations applied by a software program. Manipulating the measured radiance data computationally produces the same optical effects of a desired optical system without having to insert the optical system into the optical path of the electromagnetic radiation. The manipulated radiance data is then used to generate an image.Type: ApplicationFiled: February 10, 2019Publication date: June 6, 2019Applicant: Arizona Board of Regents on behalf of The University of ArizonaInventors: Luca CAUCCI, Harrison BARRETT
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Patent number: 10228279Abstract: A radiance sensor includes a memory and a microprocessor. The memory stores non-transitory computer-readable instructions and adapted to store a plurality of electrical signals output from a photodetector array in response to electromagnetic radiation transmitted through a lenslet array and incident on the photodetector array. The microprocessor is adapted to execute the instructions to (i) determine irradiance of the electromagnetic radiation in a detector plane from the plurality of electrical signals, each electrical signal having generated by a respective one of a plurality of photodetectors of the photodetector array, and (ii) reconstruct, from the determined irradiance, the 4D-radiance in an input plane, the lenslet array being between the input plane and the detector plane.Type: GrantFiled: April 21, 2017Date of Patent: March 12, 2019Assignee: Arizona Board of Regents on behalf of The University of ArizonaInventors: Luca Caucci, Harrison Barrett
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Patent number: 9977136Abstract: The present invention provides methods and systems for 3D imaging of in vivo and ex vivo tissues. The disclosed systems and methods employ an autoradiographic approach where particles emitted by a radioactive composition within the tissue are detected. Once detected, a 3D representation of the source of particles within the tissue is reconstructed for viewing and analysis.Type: GrantFiled: October 10, 2017Date of Patent: May 22, 2018Assignees: The Arizona Board of Regents on Behalf of The University of Arizona, inviCRO, LLCInventors: Harrison H. Barrett, Brian Miller, Yijun Ding, Liying Chen, John William Hoppin, Luca Caucci
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Publication number: 20180052242Abstract: The present invention provides methods and systems for 3D imaging of in vivo and ex vivo tissues. The disclosed systems and methods employ an autoradiographic approach where particles emitted by a radioactive composition within the tissue are detected. Once detected, a 3D representation of the source of particles within the tissue is reconstructed for viewing and analysis.Type: ApplicationFiled: October 10, 2017Publication date: February 22, 2018Applicants: Arizona Board of Regents on Behalf of The University of Arizona, inviCRO, LLCInventors: Harrison H. BARRETT, Brian MILLER, Yijun DING, Liying CHEN, John William HOPPIN, Luca CAUCCI
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Publication number: 20170343460Abstract: The present invention provides autoradiography methods and systems for imaging via the detection of alpha particles, beta particles, or other charged particles. Embodiments of the methods and systems provide high-resolution 3D imaging of the distribution of a radioactive probe, such as a radiopharmaceutical, on a tissue sample. Embodiments of the present methods and systems provide imaging of tissue samples by reconstruction of a 3D distribution of a source of particles, such as a radiopharmaceutical. Embodiments of the methods and systems provide tomographic methods including microtomography, macrotomography, cryomicrotomography and cryomacrotomography.Type: ApplicationFiled: November 11, 2015Publication date: November 30, 2017Applicants: Arizona Board of Regents on Behalf of the University of Arizona, inviCro, LLCInventors: Harrison H. BARRETT, Yijun DING, Luca CAUCCI, John William HOPPIN
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Patent number: 9823364Abstract: The present invention provides methods and systems for 3D imaging of in vivo and ex vivo tissues. The disclosed systems and methods employ an autoradiographic approach where particles emitted by a radioactive composition within the tissue are detected. Once detected, a 3D representation of the source of particles within the tissue is reconstructed for viewing and analysis.Type: GrantFiled: February 3, 2015Date of Patent: November 21, 2017Assignees: Arizona Board of Regents on Behalf of the University of Arizona, Invicro, LLCInventors: Harrison H. Barrett, Brian Miller, Yijun Ding, Liying Chen, John William Hoppin, Luca Caucci
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Publication number: 20170307439Abstract: A radiance sensor includes a memory and a microprocessor. The memory stores non-transitory computer-readable instructions and adapted to store a plurality of electrical signals output from a photodetector array in response to electromagnetic radiation transmitted through a lenslet array and incident on the photodetector array. The microprocessor is adapted to execute the instructions to (i) determine irradiance of the electromagnetic radiation in a detector plane from the plurality of electrical signals, each electrical signal having generated by a respective one of a plurality of photodetectors of the photodetector array, and (ii) reconstruct, from the determined irradiance, the 4D-radiance in an input plane, the lenslet array being between the input plane and the detector plane.Type: ApplicationFiled: April 21, 2017Publication date: October 26, 2017Inventors: Luca Caucci, Harrison Barrett
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Publication number: 20170010369Abstract: The present invention provides methods and systems for 3D imaging of in vivo and ex vivo tissues. The disclosed systems and methods employ an autoradiographic approach where particles emitted by a radioactive composition within the tissue are detected. Once detected, a 3D representation of the source of particles within the tissue is reconstructed for viewing and analysis.Type: ApplicationFiled: February 3, 2015Publication date: January 12, 2017Applicants: The Arizona Board of Regents on Behalf of The Univ ersity of Arizona, inviCRO, LLCInventors: Harrison H. BARRETT, Brian MILLER, Yijun DING, Liying CHEN, John William HOPPIN, Luca CAUCCI
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Patent number: 9182289Abstract: An apparatus for estimating a wavefront parameter includes a light source, a lenslet array, a detector for detecting light generated by the light source and passed through the lenslet array, a wavefront corrective element disposed between the lenslet array and the light source; and a data analyzer configured to estimate at least one wavefront parameter at a plane located on the light source side of the corrective element. The lenslet array and the sensor array are arranged to form a wavefront sensor, and the wavefront corrective element is configured to correct an aberration of the wavefront.Type: GrantFiled: March 12, 2012Date of Patent: November 10, 2015Assignees: Canon Kabushiki Kaisha, The Arizona Board of Regents on Behalf of the University of ArizonaInventors: Harrison Barrett, Luca Caucci, Lars Furenlid, Akinori Ohkubo
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Publication number: 20130092816Abstract: An apparatus for estimating a wavefront parameter includes a light source, a lenslet array, a detector for detecting light generated by the light source and passed through the lenslet array, a wavefront corrective element disposed between the lenslet array and the light source; and a data analyzer configured to estimate at least one wavefront parameter at a plane located on the light source side of the corrective element. The lenslet array and the sensor array are arranged to form a wavefront sensor, and the wavefront corrective element is configured to correct an aberration of the wavefront.Type: ApplicationFiled: March 12, 2012Publication date: April 18, 2013Applicants: CANON KABUSHIKI KAISHA, The Arizona Board of Regents on behalf of the University of ArizonaInventors: Harrison Barrett, Luca Caucci, Lars Furenlid, Akinori Ohkubo