Patents by Inventor Luca Domenico D'Andrea

Luca Domenico D'Andrea has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Compounds modulators of VEGF activity and uses thereof
    Patent number: 9737622
    Abstract: Compounds of general formula (1): X1Y1X2Y2X3Y3X4Y4Y5X5X6Y6X7Y7X8X9X10 wherein X1-X10 are any natural or unnatural amino acids and Y1 is Gln; Y2 is Met or Leu; Y3 is He; Y4 is Pro or Ser; Y5 is His or Gly; Y6 is Gln or Pro; Y7 is He or Tyr or their homolog or ortolog are described; these compounds are able to bind to the VEGF receptors and to modulate the angiogenesis mediated by the VEG.
    Type: Grant
    Filed: April 22, 2014
    Date of Patent: August 22, 2017
    Assignee: Advanced Accelerator Applications S.A.
    Inventors: Luca Domenico D'Andrea, Carlo Pedone, Maria Caterina Turco
  • COMPOUNDS MODULATORS OF VEGF ACTIVITY AND USES THEREOF
    Publication number: 20140341814
    Abstract: Compounds of general formula (1): X1Y1X2Y2X3Y3X4Y4Y5X5X6Y6X7Y7X8X9X10 wherein X1-X10 are any natural or unnatural amino acids and Y1 is Gln; Y2 is Met or Leu; Y3 is He; Y4 is Pro or Ser; Y5 is His or Gly; Y6 is Gln or Pro; Y7 is He or Tyr or their homolog or ortolog are described; these compounds are able to bind to the VEGF receptors and to modulate the angiogenesis mediated by the VEG.
    Type: Application
    Filed: April 22, 2014
    Publication date: November 20, 2014
    Inventors: Luca Domenico D'Andrea, Carlo Pedone, Maria Caterina Turco
  • Compounds modulators of VEGF activity and uses thereof
    Patent number: 8741850
    Abstract: Compounds of general formula (1): X1Y1X2Y2X3Y3X4Y4Y5X5X6Y6X7Y7X8X9X10 wherein X1-X10 are any natural or unnatural amino acids and Y1 is Gln; Y2 is Met or Leu; Y3 is He; Y4 is Pro or Ser; Y5 is His or Gly; Y6 is Gln or Pro; Y7 is He or Tyr or their homolog or ortolog are described; these compounds are able to bind to the VEGF receptors and to modulate the angiogenesis mediated by the VEG.
    Type: Grant
    Filed: July 23, 2010
    Date of Patent: June 3, 2014
    Assignee: Advanced Accelerator Applications S.A.
    Inventors: Luca Domenico D'Andrea, Carlo Pedone, Maria Caterina Turco
  • COMPOUNDS MODULATORS OF VEGF ACTIVITY AND USES THEREOF
    Publication number: 20120114565
    Abstract: Compounds of general formula (1): X1Y1X2Y2X3Y3X4Y4Y5X5X6Y6X7Y7X8X9X10 wherein X1-X10 are any natural or unnatural amino acids and Y1 is Gln; Y2 is Met or Leu; Y3 is He; Y4 is Pro or Ser; Y5 is His or Gly; Y6 is Gln or Pro; Y7 is He or Tyr or their homolog or ortolog are described; these compounds are able to bind to the VEGF receptors and to modulate the angiogenesis mediated by the VEG.
    Type: Application
    Filed: July 23, 2010
    Publication date: May 10, 2012
    Applicant: ADVANCED ACCELERATOR APPLICATIONS S.A.
    Inventors: Luca Domenico D'Andrea, Carlo Pedone, Maria Caterina Turco
  • Compounds Modulating Vegf Receptor and Uses Thereof
    Publication number: 20090305994
    Abstract: The present invention is related to the use of compounds which bind to the Vascular Endothelial Growth Factor Receptors and modulate the angiogenic response. The compounds, which mimic the VEGF amino acid region 17-25 involved in receptor recognition thereby inhibiting or stimulating the angiogenic process, can be used in the treatment of diseases characterized by excessive or defective angiogenesis VEGF-dependent, such as chronic ischemia, cancer, proliferative retinopathy and rheumatoid arthritis, states or conditions benefiting from the formation or regeneration of new vessels, as well as in the diagnosis of pathologies which present a overexpression of VEGF receptors or as biochemical tools to analyze the cellular pathways dependent on VEGF receptor activation.
    Type: Application
    Filed: June 29, 2006
    Publication date: December 10, 2009
    Inventors: Lucas Domenico D'Andrea, Carlo Pedone, Bruno Trimarco, Guido Iaccarino, Maria Caterina Turco, Arturo Leone, Patrizia Roselli, Marina Leone, Stefania Leone