Abstract: An intervertebral implant for insertion between adjacent vertebrae. The implant includes a spacer having two end faces and defining a continuous hollow channel therein configured to receive natural bone substance; and flanges disposed on respective end faces of the spacer and extending in each respective end plane thereof for connection to the adjacent vertebrae. Each flange projects laterally beyond the spacer at at least one region of the spacer for reducing surface pressure exerted by the spacer on the vertebrae, at least one flange defining an aperture therein within a region of the hollow channel, the aperture being configured to receive a substrate therein for supporting the natural bone substance, the flanges further defining at least one perforation within a region thereof projecting laterally beyond the spacer through which the natural bone substance may grow along an outside region of the spacer.