Patents by Inventor Luca Parlanti

Luca Parlanti has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Processes for making epothilone compounds and analogs
    Patent number: 8299266
    Abstract: A process for making aziridinyl epothilone compounds according to formula G, starting from a compound according formula C where R1, R2, R3, R4, R5, R6, R12, R13, Z1 and Z2 in formulae (G) and (C) are as defined herein. The aziridinyl epothilone compounds of formula (G) are useful for the treatment of cancer.
    Type: Grant
    Filed: February 21, 2012
    Date of Patent: October 30, 2012
    Assignee: Bristol-Myers Squibb Company
    Inventors: Luca Parlanti, Jurong Yu
  • PROCESSES FOR MAKING EPOTHILONE COMPOUNDS AND ANALOGS
    Publication number: 20120178941
    Abstract: A process for making aziridinyl epothilone compounds according to formula G, starting from a compound according formula C where R1, R2, R3, R4, R5, R6, R12, R13, Z1 and Z2 in formulae (G) and (C) are as defined herein. The aziridinyl epothilone compounds of formula (G) are useful for the treatment of cancer.
    Type: Application
    Filed: February 21, 2012
    Publication date: July 12, 2012
    Inventors: Luca Parlanti, Jurong Yu
  • Processes for making epothilone compounds and analogs
    Patent number: 8143415
    Abstract: A process for making epi-epothilone compounds according to formula A.1, by reacting a compound according formula C with at least one halogenating agent followed by treatment with base, where R1, R2, R3, R4, R5, R6, R12, R13, Z1 and Z2 in formulae (A.1) and (C) are as defined herein. The epi-epothilone compounds of formula (A.1) can be converted into aziridinyl epothilone compounds, which are useful for the treatment of cancer.
    Type: Grant
    Filed: May 23, 2008
    Date of Patent: March 27, 2012
    Assignee: Bristol-Myers Squibb Company
    Inventors: Luca Parlanti, Jurong Yu
  • PROCESSES FOR MAKING EPOTHILONE COMPOUNDS AND ANALOGS
    Publication number: 20100324302
    Abstract: The present invention relates to processes for making epothilone compounds and analogs thereof, such as epi-epothilone A or epi-epothilone B, and aziridinyl-epothilone analogs.
    Type: Application
    Filed: May 23, 2008
    Publication date: December 23, 2010
    Inventors: Luca Parlanti, Jurong Yu
  • Method for preparing pyrrolotriazine compounds
    Patent number: 7534881
    Abstract: A method for aminating pyrrole derivatives and for preparing pyrrolotriazine compounds having the formula V,
    Type: Grant
    Filed: June 28, 2005
    Date of Patent: May 19, 2009
    Assignee: Bristol-Myers Squibb Company
    Inventors: Zhongping Shi, John Hynes, Luca Parlanti, Stephen T. Wrobleski
  • Method for preparing pyrrolotriazine compounds via in situ amination of pyrroles
    Patent number: 7534882
    Abstract: A method for aminating pyrrole derivatives via in situ generated chloramines and for preparing pyrrolotriazine compounds having the formula III,
    Type: Grant
    Filed: April 3, 2006
    Date of Patent: May 19, 2009
    Assignee: Bristol-Myers Squibb Company
    Inventors: Apurba Bhattacharya, Nitinchandra Patel, John Anthony Grosso, Luca Parlanti
  • Process for preparing pyrrolotriazine aniline compounds useful as kinase inhibitors
    Patent number: 7148348
    Abstract: A process is provided for the process for preparing a pyrrolotriazine aniline p38 kinase inhibitor such as amide II by the direct aminolysis of the ester I wherein ester I is reacted with a strong organometallic base, such as hexyllithium or n-butyllithium and the desired amine such as n-propylamine to form the amide II.
    Type: Grant
    Filed: August 9, 2005
    Date of Patent: December 12, 2006
    Assignee: Bristol-Myers Squibb Company
    Inventors: Reginald O. Cann, Edward J. Delaney, Junying Fan, Luca Parlanti
  • Method for preparing pyrrolotriazine compounds via in situ amination of pyrroles
    Publication number: 20060229449
    Abstract: A method for aminating pyrrole derivatives via in situ generated chloramines and for preparing pyrrolotriazine compounds having the formula III,
    Type: Application
    Filed: April 3, 2006
    Publication date: October 12, 2006
    Inventors: Apurba Bhattacharya, Nitinchandra Patel, John Grosso, Luca Parlanti
  • PROCESS FOR PREPARING PYRROLOTRIAZINE ANILINE COMPOUNDS USEFUL AS KINASE INHIBITORS
    Publication number: 20060035886
    Abstract: A process is provided for the process for preparing a pyrrolotriazine aniline p38 kinase inhibitor such as amide II by the direct aminolysis of the ester I wherein ester I is reacted with a strong organometallic base, such as hexyllithium or n-butyllithium and the desired amine such as n-propylamine to form the amide II.
    Type: Application
    Filed: August 9, 2005
    Publication date: February 16, 2006
    Inventors: Reginald Cann, Edward Delaney, Junying Fan, Luca Parlanti
  • Method for preparing pyrrolotriazine compounds
    Publication number: 20060003967
    Abstract: A method for aminating pyrrole derivatives and for preparing pyrrolotriazine compounds having the formula V,
    Type: Application
    Filed: June 28, 2005
    Publication date: January 5, 2006
    Inventors: Zhongping Shi, John Hynes, Luca Parlanti, Stephen Wrobleski
  • Process for preparing certain pyrrolotriazine compounds
    Patent number: 6933386
    Abstract: The present invention relates to a process for preparing certain pyrrolotriazine compounds of the formula and pharmaceutically acceptable salts thereof. The formula I compounds inhibit the tyrosine kinase activity of growth factor receptors such as VEGFR-2 and FGFR-1, thereby making them useful as anti-cancer agents. The formula I compounds are also useful for the treatment of other diseases associated with signal transduction pathways operating through growth factor receptors.
    Type: Grant
    Filed: July 18, 2003
    Date of Patent: August 23, 2005
    Assignee: Bristol Myers Squibb Company
    Inventors: Rajeev S. Bhide, Junying Fan, Luca Parlanti, Stephanie Barbosa, Ligang Qian, Zhen-Wei Cai, Francis S. Gibson
  • Process for preparing certain pyrrolotriazine compounds
    Publication number: 20040077858
    Abstract: The present invention relates to a process for preparing certain pyrrolotriazine compounds of the formula 1
    Type: Application
    Filed: July 18, 2003
    Publication date: April 22, 2004
    Inventors: Rajeev S. Bhide, Junying Fan, Luca Parlanti, Stephanie Barbosa, Ligang Qian, Zhen-Wei Cai, Francis S. Gibson