Patents by Inventor Luca PICCOLI

Luca PICCOLI has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Publication number: 20210131958
    Abstract: A device, a system and a method for homodyne solid-state biased coherent detection of terahertz pulses in a range between 0.1 and 11 THz, the device comprising a metallic slit between, and parallel to, two longitudinal metallic electrodes, deposited on a surface of a substrate, and covered with a layer of nonlinear material, wherein a width of the metallic slit and a thickness of the nonlinear material layer are selected in relation to a central wavelength of the THz pulses. The method comprises focusing a THz beam and a pulsed laser beam of pulse energies in a range between 10 and 100 nJ onto the metallic slit, the metallic electrodes being biased by a static DC voltage bias selected in a range between 20 VPP and 200 VPP; and retrieving a terahertz pulse waveform using the terahertz pulse repetition rate as synchronism.
    Type: Application
    Filed: November 2, 2020
    Publication date: May 6, 2021
    Inventors: Alessandro TOMASINO, Riccardo PICCOLI, Roberto MORANDOTTI, Luca RAZZARI, Yoann JESTIN
  • Publication number: 20200362026
    Abstract: The present invention provides multispecific antibodies, and antigen binding fragments thereof, that potently neutralize a cytokine and that may thus be useful in the prevention and/or treatment of inflammatory and/or autoimmune diseases. In particular, the present invention provides a multispecific antibody, or an antigen binding fragment thereof, comprising at least two different domains specifically binding to at least two different, non-overlapping sites in a cytokine and an Fc moiety. The invention also relates to nucleic acids that encode such antibodies and antibody fragments and immortalized B cells and cultured plasma cells that produce such antibodies and antibody fragments. In addition, the invention relates to the use of the antibodies and antibody fragments of the invention in screening methods as well as in the diagnosis, prophylaxis and treatment of inflammatory and/or autoimmune diseases.
    Type: Application
    Filed: November 21, 2019
    Publication date: November 19, 2020
    Inventors: Davide Corti, Antonio Lanzavecchia, Luca Piccoli
  • Publication number: 20200325220
    Abstract: The present invention provides engineered antibodies and antigen binding fragments, in which an additional functional domain is inserted into the elbow region of the antibody or antigen binding fragment. The present invention also provides nucleic acid molecules, such as vectors, encoding such antibodies and antigen binding fragments, host cells and compositions comprising such antibodies, antigen binding fragments or nucleic acid molecules and uses thereof. For example a multispecific antibody format is provided, in which an additional binding site (specificity) is inserted into the elbow region of an antibody or antigen binding fragment.
    Type: Application
    Filed: July 30, 2018
    Publication date: October 15, 2020
    Inventors: Antonio LANZAVECCHIA, Luca PICCOLI
  • Patent number: 10526404
    Abstract: The present invention provides multispecific antibodies, and antigen binding fragments thereof, that potently neutralize a cytokine and that may thus be useful in the prevention and/or treatment of inflammatory and/or autoimmune diseases. In particular, the present invention provides a multispecific antibody, or an antigen binding fragment thereof, comprising at least two different domains specifically binding to at least two different, non-overlapping sites in a cytokine and an Fc moiety. The invention also relates to nucleic acids that encode such antibodies and antibody fragments and immortalized B cells and cultured plasma cells that produce such antibodies and antibody fragments. In addition, the invention relates to the use of the antibodies and antibody fragments of the invention in screening methods as well as in the diagnosis, prophylaxis and treatment of inflammatory and/or autoimmune diseases.
    Type: Grant
    Filed: April 29, 2015
    Date of Patent: January 7, 2020
    Assignee: INSTITUTE FOR RESEARCH IN BIOMEDICINE
    Inventors: Davide Corti, Antonio Lanzavecchia, Luca Piccoli
  • Publication number: 20180186897
    Abstract: The present invention provides a pharmaceutical composition, for example a vaccine, which comprises a RIFIN, which is able to bind to a mutated LAIR-1 fragment, which broadly binds to erythrocytes infected with Plasmodium falciparum. Such a RIFIN may be useful in the prevention and/or treatment of malaria.
    Type: Application
    Filed: June 24, 2016
    Publication date: July 5, 2018
    Inventors: Antonio Lanzavecchia, Roger Geiger, Luca Piccoli
  • Publication number: 20180179274
    Abstract: The present invention provides a protein comprising a mutated LAIR-1 fragment, which broadly binds to erythrocytes infected with Plasmodium falciparum. The protein comprising the mutated LAIR-1 fragment may be useful in the prevention and/or treatment of malaria. The present invention furthermore provides a nucleic acid encoding a mutated LAIR-1 fragment, a vector comprising such a nucleic acid as well as a respective pharmaceutical composition.
    Type: Application
    Filed: June 24, 2016
    Publication date: June 28, 2018
    Inventors: Antonio Lanzavecchia, Joshua Tan, Abdi Abdirahman, Kathrin Pieper, Luca Piccoli, Peter Charles Bull
  • Publication number: 20180142014
    Abstract: The present invention provides multispecific antibodies, and antigen binding fragments thereof, that potently neutralize a cytokine and that may thus be useful in the prevention and/or treatment of inflammatory and/or autoimmune diseases. In particular, the present invention provides a multispecific antibody, or an antigen binding fragment thereof, comprising at least two different domains specifically binding to at least two different, non- overlapping sites in a cytokine and an Fc moiety. The invention also relates to nucleic acids that encode such antibodies and antibody fragments and immortalized B cells and cultured plasma cells that produce such antibodies and antibody fragments. In addition, the invention relates to the use of the antibodies and antibody fragments of the invention in screening methods as well as in the diagnosis, prophylaxis and treatment of inflammatory and/or autoimmune diseases.
    Type: Application
    Filed: April 29, 2015
    Publication date: May 24, 2018
    Inventors: Davide CORTI, Antonio LANZAVECCHIA, Luca PICCOLI