Patents by Inventor Luca Rastelli

Luca Rastelli has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Novel proteins and nucleic acids encoding same
    Publication number: 20060084054
    Abstract: The present invention provides novel isolated polynucleotides and small molecule target polypeptides encoded by the polynucleotides. Antibodies that immunospecifically bind to a novel small molecule target polypeptide or any derivative, variant, mutant or fragment of that polypeptide, polynucleotide or antibody are disclosed, as are methods in which the small molecule target polypeptide, polynucleotide and antibody are utilized in the detection and treatment of a broad range of pathological states. More specifically, the present invention discloses methods of using recombinantly expressed and/or endogenously expressed proteins in various screening procedures for the purpose of identifying therapeutic antibodies and therapeutic small molecules associated with diseases. The invention further discloses therapeutic, diagnostic and research methods for diagnosis, treatment, and prevention of disorders involving any one of these novel human nucleic acids and proteins.
    Type: Application
    Filed: June 4, 2003
    Publication date: April 20, 2006
    Inventors: John Alsobrook, David Anderson, Jason Baumgartner, Constance Berghs, Ferenc Boldog, Catherine Burgess, Stacie Casman, Elina Catterton, Mohanraj Dhanabal, Shlomit Edinger, Karen Ellerman, Seth Ettenberg, Esha Gangolli, Valerie Gerlach, Linda Gorman, William Grosse, Erik Gunther, Xiaojia Guo, Vladimir Gusev, John Herrmann, Weizhen Ji, Ramesh Kekuda, Nikolai Khramtsov, William LaRochelle, Li Li, Hongping Liang, Kenneth Low, John MacDougall, Timothy Maclachlan, Uriel Malyankar, Kelly McQueeney, Amanda Mezick, Charles Miller, Isabelle Millet, Muralidhara Padigaru, Meera Patturajan, John Peyman, Xiaozhong Qian, Luca Rastelli, Daniel Rieger, Mark Rothenberg, Suresh Shenoy, Richard Shimkets, Glennda Smithson, Kimberly Spytek, David Stone, Sujatha Sukumaran, Edward Szekeres, Corine Vernet, Edward Voss, Adam Wolenc, Mei Zhong, Haihong Zhong
  • Angiogenesis associated proteins, and nucleic acids encoding the same
    Publication number: 20060074023
    Abstract: An isolated polypeptide having at least 80% sequence identity to the sequence SEQ ID NOS:2, 4, 6, 8, 10, 12, 14 or 16, and polynucleotides encoding the same, are useful for modulating angiogenesis.
    Type: Application
    Filed: November 22, 2005
    Publication date: April 6, 2006
    Applicants: CuraGen Corporation, Genentech, Inc.
    Inventors: Mary Gerritsen, Luca Rastelli
  • Therapeutic polypeptides, nucleic acids encoding same, and methods of use
    Publication number: 20060063200
    Abstract: Disclosed herein are nucleic acid sequences that encode G-coupled protein-receptor related polypeptides. Also disclosed are polypeptides encoded by these nucleic acid sequences, and antibodies, which immunospecifically-bind to the polypeptide, as well as derivatives, variants, mutants, or fragments of the aforementioned polypeptide, polynucleotide, or antibody. The invention further discloses therapeutic, diagnostic and research methods for diagnosis, treatment, and prevention of disorders involving any one of these novel human nucleic acids and proteins.
    Type: Application
    Filed: February 2, 2005
    Publication date: March 23, 2006
    Applicant: CuraGen Corporation
    Inventors: David Anderson, Jason Baumgartner, Ferenc Boldog, Stacie Casman, Shlomit Edinger, Esha Gangolli, Valerie Gerlach, Linda Gorman, Xiaojia Guo, Tord Hjalt, Ramesh Kekuda, Li Li, John MacDougall, Uriel Malyankar, Isabelle Millet, Muralidhara Padigaru, Meera Patturajan, Carol Pena, Luca Rastelli, Richard Shimkets, David Stone, Kimberly Spytek, Corine Vernet, Edward Voss, Bryan Zerhusen
  • Wnt-regulated cytokine-like polypeptide and nucleic acids encoding same
    Patent number: 7005499
    Abstract: The present invention provides novel polypeptides, termed FCTRX polypeptides, as well as polynucleotides encoding FCTRX polypeptides and antibodies that immunospecifically bind to an FCTRX or a derivative, variant, mutant, or fragment of an FCTRX polypeptide, polynucleotide or antibody. The invention additionally provides methods in which the FCTRX polypeptide, polynucleotide and antibody are used in detection and treatment of a broad range of pathological states, as well as to other uses.
    Type: Grant
    Filed: November 16, 2000
    Date of Patent: February 28, 2006
    Assignees: Genentech, Inc., Curagen Corporation
    Inventors: David A. Lewin, Diane Pennica, Luca Rastelli, Bruce Taillon
  • Proteins and nucleic acids encoding same
    Patent number: 6991901
    Abstract: Disclosed herein are nucleic acid sequences that encode novel polypeptides. Also disclosed are polypeptides encoded by these nucleic acid sequences, and antibodies, which immunospecifically-bind to the polypeptide, as well as derivatives, variants, mutants, or fragments of the aforementioned polypeptide, polynucleotide, or antibody. The invention further discloses therapeutic, diagnostic and research methods for diagnosis, treatment, and prevention of disorders involving any one of these novel human nucleic acids and proteins.
    Type: Grant
    Filed: January 11, 2002
    Date of Patent: January 31, 2006
    Assignee: Curagen Corporation
    Inventors: Luca Rastelli, John L. Herrmann, John R. MacDougall, Haihong Zhong
  • Proteins and nucleic acids encoding same
    Publication number: 20060013813
    Abstract: Disclosed herein are nucleic acid sequences that encode novel polypeptides. Also disclosed are polypeptides encoded by these nucleic acid sequences, and antibodies, which immunospecifically-bind to the polypeptide, as well as derivatives, variants, mutants, or fragments of the aforementioned polypeptide, polynucleotide, or antibody. The invention further discloses therapeutic, diagnostic and research methods for diagnosis, treatment, and prevention of disorders involving any one of these novel human nucleic acids and proteins.
    Type: Application
    Filed: February 8, 2005
    Publication date: January 19, 2006
    Inventors: Peter Mezes, Luca Rastelli, John Herrmann, John MacDougall, Haihong Zhong, Stacie Casman, Frenc Boldog, Richard Shimkets, Linda Gorman, Andrew Eisen, Steven Spaderna, Corine Vernet, Constance Berghs, Kimberly Spytek, Vincent DiPippo, Bryan Zerhusen, John Peyman, Karen Ellerman, David Stone, William Grosse, John Alsobrook, Denise Lepley, Daniel Rieger, Catherine Burgess, Sholmit Edinger, Edward Voss, Charles Miller
  • Therapeutic polypeptides, nucleic acids encoding same, and methods of use
    Publication number: 20060003323
    Abstract: Disclosed herein are nucleic acid sequences that encode novel polypeptides. Also disclosed are polypeptides encoded by these nucleic acid sequences, and antibodies that immunospecifically bind to the polypeptide, as well as derivatives, variants, mutants, or fragments of the novel polypeptide, polynucleotide, or antibody specific to the polypeptide. Vectors, host cells, antibodies and recombinant methods for producing the polypeptides and polynucleotides, as well as methods for using same are also included. The invention further discloses therapeutic, diagnostic and research methods for diagnosis, treatment, and prevention of disorders involving any one of these novel human nucleic acids and proteins.
    Type: Application
    Filed: June 3, 2003
    Publication date: January 5, 2006
    Inventors: John Alsobrook, Enrique Alvarez, David Anderson, Ferenc Boldog, Stacie Casman, Elina Catterton, Andrei Chapoval, Julie Crabtree-Bokor, Shlomit Edinger, Karen Ellerman, Seth Ettenberg, Esha Gangolli, Valerie Gerlach, Linda Gorman, Erik Gunther, Xiaojia (Sasha) Guo, Vladimir Gusev, John Herrmann, Weizhen Ji, Ramesh Kekuda, Li Li, Xiaohong Liu, John MacDougall, Timothy Machlachlan, Uriel Malyankar, Amanda Mezick, Isabelle Millet, Vishnu Mishra, Muralidhara Padigaru, Meera Patturajan, Carol Pena, John Peyman, Debasish Raha, Luca Rastelli, Daniel Rieger, Mark Rothenberg, Paul Sciore, Suresh Shenoy, Richard Shimkets, Glennda Smithson, Kimberly Spytek, David Stone, Corine Vernet, Edward Voss, Mei Zhong, Hiahong Zhong
  • NOVEL POLYPEPTIDES AND NUCLEIC ACIDS ENCODED THEREBY
    Publication number: 20050288241
    Abstract: Disclosed are novel polypeptides and nucleic acids encoding same. Also disclosed are vectors, host cells, antibodies and recombinant methods for producing the polypeptides and polynucleotides, as well as methods for using same.
    Type: Application
    Filed: January 22, 2002
    Publication date: December 29, 2005
    Inventors: Luca Rastelli, Xiaojia Guo
  • Proteins and nucleic acids encoding same
    Patent number: 6964849
    Abstract: Disclosed herein are nucleic acid sequences that encode novel polypeptides. Also disclosed are polypeptides encoded by these nucleic acid sequences, and antibodies, which immunospecifically-bind to the polypeptide, as well as derivatives, variants, mutants, or fragments of the aforementioned polypeptide, polynucleotide, or antibody. The invention further discloses therapeutic, diagnostic and research methods for diagnosis, treatment, and prevention of disorders involving any one of these novel human nucleic acids and proteins.
    Type: Grant
    Filed: March 15, 2002
    Date of Patent: November 15, 2005
    Assignee: Curagen Corporation
    Inventors: Luca Rastelli, John L. Herrmann, John R. MacDougall, Haihong Zhong
  • WNT-regulated cytokine-like polypeptide and nucleic acids encoding same
    Publication number: 20050250178
    Abstract: The present invention provides novel polypeptides, termed FCTRX polypeptides, as well as polynucleotides encoding FCTRX polypeptides and antibodies that immunospecifically bind to an FCTRX or a derivative, variant, mutant, or fragment of an FCTRX polypeptide, polynucleotide or antibody. The invention additionally provides methods in which the FCTRX polypeptide, polynucleotide and antibody are used in detection and treatment of a broad range of pathological states, as well as to other uses.
    Type: Application
    Filed: July 7, 2003
    Publication date: November 10, 2005
    Inventors: David Andrew, David Lewin, Diane Pennica, Luca Rastelli, Bruce Tallion
  • Ten-M3 polypeptides and polynucleotides and their methods of use
    Publication number: 20050244868
    Abstract: Disclosed herein are novel Ten-M3 polynucleotides encoding novel polypeptides and antibodies that immunospecifically bind to the polypeptide, as well as derivatives, variants, mutants, or fragments of the novel polypeptide, polynucleotide, or antibody specific to the polypeptide. Vectors, host cells, antibodies and recombinant methods for producing the polypeptides and polynucleotides, as well as methods for using same are also included. The invention further discloses therapeutic, diagnostic and research methods for diagnosis, treatment, and prevention of disorders involving any one of these novel human nucleic acids and proteins.
    Type: Application
    Filed: March 30, 2005
    Publication date: November 3, 2005
    Inventors: Ramesh Kekuda, Timothy MacLachlan, Meera Patturajan, Luca Rastelli, Seth Ettenberg, Corine Vernet
  • Method of detecting and treating tuberous sclerosis complex associated disorders
    Publication number: 20050181391
    Abstract: Disclosed are methods of detecting and treating tuberous sclerosis complex associated disorders. Also disclosed are methods of identifying agents for treating tuberous sclerosis complex associated disorders.
    Type: Application
    Filed: November 16, 2004
    Publication date: August 18, 2005
    Inventors: Luca Rastelli, Bonnie Gould-Rothberg, Ryan Murphey
  • Novel human proteins and polynucleotides encoding them
    Publication number: 20050170380
    Abstract: The present invention provides novel isolated SECX polynucleotides and the membrane-associated or secreted polypeptides encoded by the SECX polynucleotides. Also provided are the antibodies that immunospecifically bind to a SECX polypeptide or any derivative, variant, mutant or fragment of the SECX polypeptide, polynucleotide or antibody. The invention additionally provides methods in which the SECX polypeptide, polynucleotide and antibody are utilized in the detection and treatment of a broad range of pathological states, as well as to other uses.
    Type: Application
    Filed: October 21, 2004
    Publication date: August 4, 2005
    Applicant: CuraGen Corporation
    Inventors: Elma Fernandes, Corine Vernet, Richard Shimkets, David Anderson, Muralidhara Padigaru, Ferenc Boldog, Li Li, Suresh Shenoy, Stacie Casman, Luca Rastelli
  • Novel polypeptides, and nucleic acids encoding the same
    Publication number: 20050159373
    Abstract: An isolated polypeptide comprising an amino acid sequence having at least 80% sequence identity to the sequence SEQ ID NOS:2, 4, 6 or 8, polynucleotides encoding these peptides, and antibodies to the polypeptides are useful in treating cancers.
    Type: Application
    Filed: April 24, 2003
    Publication date: July 21, 2005
    Applicants: CuraGen Corporation, Genentech, Inc.
    Inventors: Diane Pennica, Luca Rastelli
  • Novel proteins and nucleic acids encoding same
    Publication number: 20050153305
    Abstract: Disclosed herein are novel human nucleic acid sequences which encode polypeptides. Also disclosed are polypeptides encoded by these nucleic acid sequences, and antibodies which immunospecifically-bind to the polypeptide, as well as derivatives, variants, mutants, or fragments of the aforementioned polypeptide, polynucleotide, or antibody. The invention further discloses therapeutic, diagnostic and research methods for diagnosis, treatment, and prevention of disorders involving any one of these novel human nucleic acids and proteins.
    Type: Application
    Filed: May 21, 2004
    Publication date: July 14, 2005
    Inventors: Corine Vernet, Catherine Burgess, Elma Fernandes, Raymond Taupier, Kerry Quinn, Kimberly Spytek, Luca Rastelli, John Herrmann
  • Novel sphingosine kinases
    Publication number: 20050123942
    Abstract: Disclosed herein are novel human nucleic acid sequences that encode polypeptides. Also disclosed are polypeptides encoded by these nucleic acid sequences, and antibodies that immunospecifically-bind to the polypeptide, as well as derivatives, variants, mutants, or fragments of the aforementioned polypeptide, polynucleotide, or antibody. The invention further discloses therapeutic, diagnostic and research methods for diagnosis, treatment, and prevention of disorders involving any one of these novel human nucleic acids and proteins.
    Type: Application
    Filed: June 24, 2004
    Publication date: June 9, 2005
    Applicants: Genentech, Inc., Curagen Corporation
    Inventors: Mary Gerritsen, Luca Rastelli
  • Sphingosine kinases
    Patent number: 6858427
    Abstract: Disclosed herein are novel human nucleic acid sequences that encode polypeptides. Also disclosed are polypeptides encoded by these nucleic acid sequences, and antibodies that immunospecifically-bind to the polypeptide, as well as derivatives, variants, mutants, or fragments of the aforementioned polypeptide, polynucleotide, or antibody. The invention further discloses therapeutic, diagnostic and research methods for diagnosis, treatment, and prevention of disorders involving any one of these novel human nucleic acids and proteins.
    Type: Grant
    Filed: February 14, 2001
    Date of Patent: February 22, 2005
    Assignee: Genentech, Inc.
    Inventors: Mary E. Gerritsen, Luca Rastelli
  • Therapeutic polypeptides, nucleic acids encoding same, and methods of use
    Publication number: 20050014687
    Abstract: Disclosed herein are nucleic acid sequences that encode novel polypeptides. Also disclosed are polypeptides encoded by these nucleic acid sequences, and antibodies that immunospecifically bind to the polypeptide, as well as derivatives, variants, mutants, or fragments of the novel polypeptide, polynucleotide, or antibody specific to the polypeptide. Vectors, host cells, antibodies and recombinant methods for producing the polypeptides and polynucleotides, as well as methods for using same are also included. The invention further discloses therapeutic, diagnostic and research methods for diagnosis, treatment, and prevention of disorders involving any one of these novel human nucleic acids and proteins.
    Type: Application
    Filed: March 19, 2003
    Publication date: January 20, 2005
    Inventors: David Anderson, Loic Giot, Xiaojia Guo, Denise Lepley, Mehdi Mesri, Chean Ooi, Luca Rastelli, Daniel Rieger, Glennda Smithson, Gary Starling, Kam-Fai Tse
  • Therapeutic polypeptides, nucleic acids encoding same, and methods of use
    Publication number: 20040259774
    Abstract: Disclosed herein are nucleic acid sequences that encode novel polypeptides. Also disclosed are polypeptides encoded by these nucleic acid sequences, and antibodies that immunospecifically bind to the polypeptide, as well as derivatives, variants, mutants, or fragments of the novel polypeptide, polynucleotide, or antibody specific to the polypeptide. Vectors, host cells, antibodies and recombinant methods for producing the polypeptides and polynucleotides, as well as methods for using same are also included. The invention further discloses therapeutic, diagnostic and research methods for diagnosis, treatment, and prevention of disorders involving any one of these novel human nucleic acids and proteins.
    Type: Application
    Filed: February 3, 2003
    Publication date: December 23, 2004
    Inventors: Enrique Alvarez, Shlomit R. Edinger, Esha A. Gangolli, Valerie Gerlach, Linda Gorman, Xiaojia (Sasha) Guo, Weizhen Ji, Ramesh Kekuda, Li Li, Charles E. Miller, Muralidhara Padigaru, Meera Patturajan, Luca Rastelli, Daniel K. Rieger, Suresh G. Shenoy, Richard A. Shimkets, Kimberly A. Spytek, Mei Zhong
  • Therapeutic polypeptides, nucleic acids encoding same, and methods of use
    Publication number: 20040162236
    Abstract: Disclosed herein are nucleic acid sequences that encode novel polypeptides. Also disclosed are polypeptides encoded by these nucleic acid sequences, and antibodies that immunospecifically bind to the polypeptide, as well as derivatives, variants, mutants, or fragments of the novel polypeptide, polynucleotide, or antibody specific to the polypeptide. Vectors, host cells, antibodies and recombinant methods for producing the polypeptides and polynucleotides, as well as methods for using same are also included. The invention further discloses therapeutic, diagnostic and research methods for diagnosis, treatment, and prevention of disorders involving any one of these novel human nucleic acids and proteins.
    Type: Application
    Filed: March 31, 2003
    Publication date: August 19, 2004
    Inventors: John Alsobrook, Patricia Bento, Ferenc Boldog, Catherine Burgess, Stacie Casman, Julie Crabtree Bokor, Shlomit R. Edinger, Karen Ellerman, Elma Fernandes, Valerie Gerlach, William Grosse, Erik Gunther, Vladimir Gusev, Melvyn Heyes, Denise Lepley, Li Li, John R. MacDougall, Uriel M. Malyankar, Isabelle Millet, Meera Patturajan, John A. Peyman, Luca Rastelli, Daniel Rieger, Suresh Shenoy, Richard Shimkets, Glennda Smithson, David Stone, Corine Vernet, Edward Voss