Patents by Inventor Luca SARTORI

Luca SARTORI has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • HECT E3 LIGASE INHIBITORS AND USES THEREOF
    Publication number: 20220339163
    Abstract: The present invention relates to tricyclic derivatives of formula (I), which are useful as inhibitors of HECT-domain-containing E3 ligases, in particular NEDD4. The present invention also refers to pharmaceutical compositions comprising compounds of formula (I), to their medical use and to their process of preparation.
    Type: Application
    Filed: June 3, 2020
    Publication date: October 27, 2022
    Applicants: IFOM - FONDAZIONE ISTITUTO FIRC DI ONCOLOGIA MOLECOLARE, IEO - ISTITUTO EUROPEO DI ONCOLOGIA S.R.L.
    Inventors: Sebastiano PASQUALATO, Maurizio PASI, Raffaella AMICI, Mario VARASI, Ciro MERCURIO, Luca SARTORI, Simona POLO, Elena MASPERO, Giovanni FAGA'
  • Indole derivatives as histone demethylase inhibitors
    Patent number: 10980777
    Abstract: The present application relates to compounds of formula (I), wherein A, R, R1, and R2 are as defined in the specification, pharmaceutical compositions containing such compounds and to their use in therapy.
    Type: Grant
    Filed: August 17, 2018
    Date of Patent: April 20, 2021
    Assignee: Istituto Europeo di Oncologia S.r.l.
    Inventors: Mario Varasi, Anna Cappa, Paola Vianello, Loris Moretti, Luca Sartori, Ciro Mercurio
  • Imidazoles as histone demethylase inhibitors
    Patent number: 10961255
    Abstract: The present invention relates to imidazole derivatives, wherein A, R, R1, and R2 are as defined in the specification, pharmaceutical compositions containing such compounds and to their use in therapy.
    Type: Grant
    Filed: December 20, 2019
    Date of Patent: March 30, 2021
    Assignee: Istituto Europeo di Oncologia S.r.l.
    Inventors: Paola Vianello, Alessia Romussi, Anna Cappa, Paolo Trifiro′, Mario Varasi, Luca Sartori, Ciro Mercurio
  • IMIDAZOLES AS HISTONE DEMETHYLASE INHIBITORS
    Publication number: 20200299303
    Abstract: The present invention relates to imidazole derivatives, wherein A, R, R1, and R2 are as defined in the specification, pharmaceutical compositions containing such compounds and to their use in therapy.
    Type: Application
    Filed: December 20, 2019
    Publication date: September 24, 2020
    Inventors: Paola VIANELLO, Alessia ROMUSSI, Anna CAPPA, Paolo TRIFIRO', Mario VARASI, Luca SARTORI, Ciro MERCURIO
  • INDOLE DERIVATIVES AS HISTONE DEMETHYLASE INHIBITORS
    Publication number: 20200289463
    Abstract: The present application relates to compounds of formula (I), wherein A, R, R1, and R2 are as defined in the specification, pharmaceutical compositions containing such compounds and to their use in therapy.
    Type: Application
    Filed: August 17, 2018
    Publication date: September 17, 2020
    Inventors: Mario VARASI, Anna CAPPA, Paola VIANELLO, Loris MORETTI, Luca SARTORI, Ciro MERCURIO
  • Imidazoles as histone demethylase inhibitors
    Patent number: 10562914
    Abstract: The present invention relates to imidazole derivatives of Formula (I), wherein A, R, R1, and R2 are as defined in the specification, pharmaceutical compositions containing such compounds and to their use in therapy.
    Type: Grant
    Filed: May 18, 2017
    Date of Patent: February 18, 2020
    Assignee: Istituto Europeo di Oncologia S.r.l.
    Inventors: Paola Vianello, Alessia Romussi, Anna Cappa, Paolo Trifiro', Mario Varasi, Luca Sartori, Ciro Mercurio
  • IMIDAZOLES AS HISTONE DEMETHYLASE INHIBITORS
    Publication number: 20190152987
    Abstract: The present invention relates to imidazole derivatives of Formula (I), wherein A, R, R1, and R2 are as defined in the specification, pharmaceutical compositions containing such compounds and to their use in therapy.
    Type: Application
    Filed: May 18, 2017
    Publication date: May 23, 2019
    Inventors: Paola VIANELLO, Alessia ROMUSSI, Anna CAPPA, Paolo TRIFIRO', Mario VARASI, Luca SARTORI, Ciro MERCURIO
  • Thienopyrroles as histone demethylase inhibitors
    Patent number: 10183952
    Abstract: The present application relates to thienopyrrole derivatives, compounds of Formulas (I) and (Ia), wherein R, R1, R2 and R3 are as defined in the specification, pharmaceutical compositions containing such compounds and to their use in therapy. The compounds of the application can be useful for inhibiting KDM1 and the prevention and/or treatment of cancer, infectious disease, or a disease characterized by aberration of cellular energy metabolism, e.g., obesity.
    Type: Grant
    Filed: September 4, 2015
    Date of Patent: January 22, 2019
    Assignee: Istituto Europeo di Oncologia S.r.l.
    Inventors: Paola Vianello, Luca Sartori, Mario Varasi, Ciro Mercurio, Elisa Zagarri, Anna Cappa, Alessia Romussi, Manuela Villa, Giuseppe Meroni, Loris Moretti
  • THIENOPYRROLES AS HISTONE DEMETHYLASE INHIBITORS
    Publication number: 20170260197
    Abstract: The present application relates to thienopyrrole derivatives, compounds of Formulas (I) and (Ia), wherein R, R1, R2 and R3 are as defined in the specification, pharmaceutical compositions containing such compounds and to their use in therapy. The compounds of the application can be useful for inhibiting KDM1 and the prevention and/or treatment of cancer, infectious disease, or a disease characterized by aberration of cellular energy metabolism, e.g., obesity.
    Type: Application
    Filed: September 4, 2015
    Publication date: September 14, 2017
    Inventors: Paola VIANELLO, Luca SARTORI, Mario VARASI, Ciro MERCURIO, Elisa ZAGARRI, Anna CAPPA, Alessia ROMUSSI, Manuela VILLA, Giuseppe MERONI, Loris MORETTI