Patents by Inventor Lucas A. T. Hilgers

Lucas A. T. Hilgers has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Adjuvant composition containing synthetic hydrophobic lipopolysaccharide
    Patent number: 5976538
    Abstract: According to the present invention the adjuvants comprise an emulsion containing at least one synthetic hydrophobic lipopolysaccharide, which can either or not be provided with anionic groups, while maintaining the overall hydrophobicity, an interface-forming constituent (such as an oil) and optionally an aqueous solute. In particular the adjuvant and vaccines prepared with it contain a lipopolysaccharide which had an HLB value of less then 9, more favorably less than 4.
    Type: Grant
    Filed: November 15, 1996
    Date of Patent: November 2, 1999
    Assignee: American Cyanamid Company
    Inventors: Lucas A.T. Hilgers, Peter-Paul L.I. Platenburg
  • Method of stabilizing colostrum for immunochemical examination
    Patent number: 5143848
    Abstract: A method of stabilizing a sample of colostrum or milk which is intended for immunochemical examination, by adding a stabilizing system which comprises the following components:(a) a microbiological preservative,(b) a buffer solution which buffers the sample at a pH between 5 and 8, preferably between 5.5 and 6.5, and(c) one or more non-ionic surface-active substances, the components (a), (b) and (c) being selected in such manner that they do not interfere with the immunochemical examination to be carried out. The invention also relates to the stabilization kit to be used for this purpose.
    Type: Grant
    Filed: September 10, 1990
    Date of Patent: September 1, 1992
    Assignee: Duphar International Research B.V.
    Inventors: Rudolf Scholten, Lucas A. T. Hilgers, Marinus W. Weststrate
  • Stabilized adjuvant suspension comprising dimethyl dioctadecyl ammonium bromide
    Patent number: 5026546
    Abstract: A stabilized aqueous adjuvant suspension of dimethyl dioctadecyl ammonium bromide stabilized with at least 0.1 part by weight of a polymer of acrylic acid crosslinked with polyallyl sucrose per part by weight of dimethyl dioctadecyl ammonium bromide, plusa method of stabilizing vaccines adjuvanted with such dimethyl dioctadecyl ammonium bromide.
    Type: Grant
    Filed: December 17, 1987
    Date of Patent: June 25, 1991
    Assignee: Duphar International Research B.V.
    Inventors: Lucas A. T. Hilgers, Marinus W. Weststrate