Patents by Inventor Lucas Alfonsus T. Hilgers

Lucas Alfonsus T. Hilgers has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Patent number: 8637659
    Abstract: The present invention relates to a novel family of monosaccharide derivatives and disaccharide derivatives and to a method of preparation thereof. A mono- and disaccharide derivatives according to the invention comprises at least one fatty acid ester and may further comprise one or more anionic groups and are useful for, inter alia, medical, pharmaceutical, cosmetic and food applications.
    Type: Grant
    Filed: May 29, 2012
    Date of Patent: January 28, 2014
    Assignee: Protherics Medicines Development Limited
    Inventors: Lucas Alfonsus T. Hilgers, Anneke Georgine Blom
  • Publication number: 20120288528
    Abstract: The present invention relates to a novel family of monosaccharide derivatives and disaccharide derivatives and to a method of preparation thereof. A mono- and disaccharide derivatives according to the invention comprises at least one fatty acid ester and may further comprise one or more anionic groups and are useful for, inter alia, medical, pharmaceutical, cosmetic and food applications.
    Type: Application
    Filed: May 29, 2012
    Publication date: November 15, 2012
    Inventors: Lucas Alfonsus T. Hilgers, Anneke Georgine Blom
  • Publication number: 20110305730
    Abstract: The present invention relates to a novel family of monosaccharide derivatives and disaccharide derivatives and to a method of preparation thereof. A mono- and disaccharide derivatives according to the invention comprises at least one fatty acid ester and may further comprise one or more anionic groups and are useful for, inter alia, medical, pharmaceutical, cosmetic and food applications.
    Type: Application
    Filed: June 16, 2011
    Publication date: December 15, 2011
    Inventors: Lucas Alfonsus, T. Hilgers, Anneke Georgine Blom
  • Patent number: 8052981
    Abstract: The present invention includes a formulation comprising a physiological salt solution, or an oil-in-water emulsion, or a water immiscible solid phase, and an adjuvant comprising one or more disaccharide derivatives derived from cellobiose, gentiobiose, lactose, lactulose, maltose, melibiose, sucrose or turanose, wherein at least four of the free hydroxyl groups of the disaccharide molecule have been modified such that the disaccharide derivative has: (i) at least 3, but not more than N-1, fatty acid ester groups, wherein each of the fatty acid ester groups is represented by a general formula of —O—C(?O)—(CH2)xCH3 wherein x is between 6 and 14, and (ii) at least one, but no more than N-1 anionic groups, wherein N is the number of hydroxyl groups of the disaccharide from which the derivative is derived and wherein the combined number of fatty acid esters and anionic groups does not exceed N.
    Type: Grant
    Filed: April 20, 2009
    Date of Patent: November 8, 2011
    Assignee: Protherics Medicines Development Limited
    Inventors: Lucas Alfonsus T. Hilgers, Anneke Georgine Blom
  • Publication number: 20090304723
    Abstract: The present invention relates to a novel family of monosaccharide derivatives and disaccharide derivatives and to a method of preparation thereof. A mono- and disaccharide derivatives according to the invention comprises at least one fatty acid ester and may further comprise one or more anionic groups and are useful for, inter alia, medical, pharmaceutical, cosmetic and food applications.
    Type: Application
    Filed: April 20, 2009
    Publication date: December 10, 2009
    Inventors: Lucas Alfonsus T. Hilgers, Anneke Georgine Blom
  • Publication number: 20030220270
    Abstract: The present invention relates to a novel family of monosaccharide derivatives and disaccharide derivatives and to a method of preparation thereof. A mono- and disaccharide derivatives according to the invention comprises at least one fatty acid ester and may further comprise one or more anionic groups and are useful for, inter alia, medical, pharmaceutical, cosmetic and food applications.
    Type: Application
    Filed: October 7, 2002
    Publication date: November 27, 2003
    Inventors: Lucas Alfonsus T. Hilgers, Anneke Georgine Blom
  • Publication number: 20030008839
    Abstract: The present invention relates to the field of vaccination. In particular, the invention relates to immunization by administration of a nucleic acid encoding a gene produce (e.g., proteins, glycoproteins, lipoproteins) of an infectious or non-infectious agent. In accordance with the invention, it has been found that dimethyldialkylammonium salts enhance the immune response of a nucleic acid vaccine.
    Type: Application
    Filed: April 23, 2002
    Publication date: January 9, 2003
    Applicant: I-D Lelystad, Instituut voor Dierhouderijen
    Inventors: Eugene Marie, A. van Rooij, Lucas Alfonsus, T. Hilgers